Uptake of radioiodinated cardiac specific troponin-I antibodies in myocardial infarction

Cummins, Bernadette; Russell, Geoffrey J; Chandler, Stephen T; Pears, D. J.; Cummins, Peter L.

doi:10.1093/cvr/24.4.317

Cited by 10 publications

(3 citation statements)

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“…It is possible that it may be useful in evaluating myocardial involvement in connective tissue disorders, alcoholic cardiomyopathy and sarcoidosis, to name a few. troponin I (Cummins et al 1990), may also be advantageous. Technetium 99m antimyosin, which has a more rapid clearance from the blood pool and superior imaging qualities compared with 111In (and is also less expensive) has recently entered the clinical trial phase, and the results appear promising (Senior et al 1991).…”

Section: Conclusion and The Futurementioning

confidence: 99%

Clinical role of indium-111 antimyosin imaging

Bhattacharya

Lahiri

1991

Eur J Nucl Med

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Myocyte necrosis occurs in ischaemic, inflammatory and toxic heart diseases and can be detected by indium-111 antimyosin imaging. This allows a non-invasive evaluation of the site, extent and quantitation of the severity of myocardial necrosis. Simultaneous imaging of perfusion in patients with myocardial infarction allows the differentiation of necrosed and perfused areas and the varying degrees of mismatch and overlap, which has prognostic significance. 111In-antimyosin imaging is useful in the assessment of patients with unstable angina and in those for whom the diagnosis of infarction or unstable angina is not clear. In suspected myocarditis, a positive scan indicates the necessity for endomyocardial biopsy to confirm inflammation, whereas a negative scan makes the diagnosis of myocarditis unlikely. Antimyosin imaging is not useful as a marker of rejection in the 1 year post-transplant, but uptake after this period is associated with an increased rejection rate and is therefore an important tool in planning management strategies. Most patients on anthracycline treatment have demonstrable uptake, which is related to the cumulative dose and to the ejection fraction. Its role in this situation is as yet unclear. The use of new ligands and radioisotopes (99mTc) is likely to allow earlier imaging and produce improved quality.

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Section: Conclusion and The Futurementioning

confidence: 99%

Clinical role of indium-111 antimyosin imaging

Bhattacharya

Lahiri

1991

Eur J Nucl Med

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“…Amongst these macromolecules, the contractile and regulatory proteins of the myocardium are considered to be of particular significance . This is due to the expression of the cardiac-specific isoforms of these proteins, their higher intracellular concentration (Swynghedauw, 1986) and continuous release from the infarcting myocardium (Leger et al, 1985, Katus et a/., and affinity purified antibodies (Cummins et at., 1990), raised against cardiac proteins, have been examined in vitro as well as in experimentally-induced myocardial infarctions.…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported to exist in three isoforms, encoded by three different genes (Hunkler et at., 1991) with distribution of the cardiac specific form, mol wt 24Kd, only in the cardiac muscle. cTn-I is considered to be of significance for both the in vitro as well as in vivo diagnosis ofMI due to its cardiac specificity, uniform distribution in the cardiac muscle, unique location in myofibrillar structure and release characteristics from the necrotising cardiac tissue in the event of MI (Cummins et al, , 1990Haider and Stimson, 1993).…”

Section: Introductionmentioning

confidence: 99%

Production and Characterisation of Anti-Cardiac Troponin-I Monoclonal Antibodies

Haider

Stimson

1994

Disease Markers

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Cardiac troponin-I (cTn-I) was isolated from bovine left ventricular tissue and used as immunogen. Sixteen murine hybridoma lines were produced with two of them. I D 12 and 5F4, showing a high specificity for cTn-I; both of these monoclonal antibodies (McAbs) were isotyped as IgG I with kappa - light chains. The specificity of the McAbs for cTn-1 was confirmed by ELISA, western blotting and by the ability of the antibodies to block actomyosin ATPase inhibition by cTn-I. The McAbs may be useful for human ill vivo imaging of myocardial infarcts and other pathological conditions related to cardiac myocyte damage.

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Myocardial infarct imaging with cardiac troponin-I antibodies

Cummins¹

1992

Developments in Cardiovascular Medicine

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Uptake of radioiodinated cardiac specific troponin-I antibodies in myocardial infarction

Cited by 10 publications

References 0 publications

Clinical role of indium-111 antimyosin imaging

Clinical role of indium-111 antimyosin imaging

Production and Characterisation of Anti-Cardiac Troponin-I Monoclonal Antibodies

Myocardial infarct imaging with cardiac troponin-I antibodies

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