Uptake of Mercury Vapour in Blood in Vivo and in Vitro from Hg‐containing Air

Kudsk, F. Nielsen

doi:10.1111/j.1600-0773.1969.tb00502.x

Acta Pharmacologica et Toxicologica

1969

DOI: 10.1111/j.1600-0773.1969.tb00502.x

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Uptake of Mercury Vapour in Blood in Vivo and in Vitro from Hg‐containing Air

F. Nielsen Kudsk

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1981

2010

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Cited by 30 publications

References 15 publications

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Scopoli's work in the field of mercurialism in light of today's knowledge: Past and present perspectives

Kobal

Grum

2010

American J Industrial Med

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The Idrija Mercury Mine (1490-1994) appointed its first physician, Joannes Antonius Scopoli, in 1754. Most of his descriptions of mercurialism are still relevant today. This study highlights Scopoli's observations on the interaction between elemental mercury (Hg degrees ) and alcohol, on the appearance of lung impairment, insomnia, and depressive mood in mercurialism. This presentation is based on Scopoli's experiences presented in his book, De Hydrargyro Idriensi Tentamina (1761), current knowledge, and our own experience acquired through health monitoring of occupational Hg degrees exposure. Some studies have confirmed Scopoli's observation that alcohol enhances mercurialism and his hypothesis that exposure to high Hg degrees concentrations causes serious lung impairment. Neurobiological studies have highlighted the influence of Hg degrees on sleep disorder and depressive mood observed by Scopoli. Although today's knowledge provides new perspectives of Scopoli's work on mercurialism, his work is still very important and can be considered a part of occupational medicine heritage.

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Scopoli's work in the field of mercurialism in light of today's knowledge: Past and present perspectives

Kobal

Grum

2010

American J Industrial Med

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Selective determination of elemental mercury in blood and urine exposed to mercury vapor in vitro

Satoh

Hursh

Clarkson

et al. 1981

J of Applied Toxicology

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A method is described to ensure quantitative measurement of dissolved mercury vapor (Hg0) in blood and urine. Room air passed through samples of blood and urine carries with it all the dissolved Hg0 but leaves behind all the ionic mercury (Hg++). Oxidation of Hg0 to Hg++ in blood samples is completely inhibited by addition of ethanol (0.5% v/v). To minimize error due to evaporation of Hg0, it is suggested that samples should be stored at 0 degree C and Hg0 should be determined within 60 min of collection of blood samples and within 10 min of urine samples.

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Whole body and liver distribution of inhaled mercury vapor in the mouse: Influence of ethanol and aminotriazole pretreatment

Khayat

Dencker

1983

J of Applied Toxicology

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Inhalation of radioactive metallic mercury vapor (203Hg0) in the mouse resulted in an accumulation of mercury in several organs where no specific uptake was observed after i.v. injection of inorganic mercury (203Hg2+). This was true for the whole respiratory epithelium (including the lung parenchyma), myocardium, brain, retina of the eye, adrenal cortex, corpora lutea of the ovary, epididymis, brown fat and thyroid gland. It is assumed that these organs have a high capacity for oxidizing Hg0 to Hg2+, which will then be retained in the tissues. Ethanol and aminotriazole (catalase inhibitors) decreased the concentration in several of these organs, although not in an exactly similar pattern. In the livers of non-treated animals, most of the inhaled mercury accumulated in the hepatocytes in the periphery of the lobuli (periportal region), close to where the blood vessels enter the liver parenchyma. Treatment with ethanol or aminotriazole increased the liver mercury content, with more or less all the hepatocytes apparently engaged in the oxidation of Hg0.

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Uptake of Mercury Vapour in Blood in Vivo and in Vitro from Hg‐containing Air

Cited by 30 publications

References 15 publications

Scopoli's work in the field of mercurialism in light of today's knowledge: Past and present perspectives

Scopoli's work in the field of mercurialism in light of today's knowledge: Past and present perspectives

Selective determination of elemental mercury in blood and urine exposed to mercury vapor in vitro

Whole body and liver distribution of inhaled mercury vapor in the mouse: Influence of ethanol and aminotriazole pretreatment

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