Uptake of C60 by human monocyte macrophages, its localization and implications for toxicity: Studied by high resolution electron microscopy and electron tomography

Porter, Alexandra E.; Müller, Karin H.; Skepper, Jeremy N.; Midgley, Paul A.; Welland, Mark E.

doi:10.1016/j.actbio.2006.02.006

Cited by 140 publications

(99 citation statements)

References 27 publications

(42 reference statements)

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“…This is in line with other study, where reported that a noticeable and statistically significant (p<0,001) influence on phospholipid vesicles were observed after incubation of ZnO (but not TiO 2 ) nanoparticles [33]. This is known that agglomerates larger than 0,2 μm were found attached to the membrane [34], whereas smaller aggregates and single particles could probably cross the membrane through pores or ion channels [35]. In addition, aggregates adhere to surfaces may therefore cause effects without even entering cells.…”

Section: Zno and Tio 2 Np's Interaction With Slbsupporting

confidence: 80%

Effect of Zinc Oxide and Titanium Dioxide Nanoparticles on Supported Lipid Bilayers

Grinceviciute¹,

Verdes²,

Snitka³

2015

JNMR

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Nanoparticles (NP) are broadly exploited in biomedical sciences in order to develop various methods of targeted drug delivery, novel biosensors and new therapeutic pathways. However, relatively little is known in the negotiation of NPs with complex biological environments. NP interaction with cell membranes can damage the cell membrane and cause toxicity; therefore, examining interactions between NPs and cell membranes is crucial to understanding NP toxicity mechanisms and the development of safe and non-toxic NP-based commercial and therapeutic applications. To gain a physical understanding of NP-membrane interactions, we used a simplified system built of well-defined synthetic lipid bilayers and NP. The interaction of nanoparticles (NPs) with supported lipid bilayers (SLB) can lead to structural modification of the SLB and affect the structure and dynamic of lipids. In this work TiO 2 and ZnO nanoparticles were chosen because of wide applications and usage in industry of papers, inks, medicines, food products, cosmetics, toothpastes and skin care products and among others. Therefore, a better understanding of the interactions between NP and lipid membrane may help to better clarify the potential risk of NPs. The interaction between ZnO and TiO 2 NPs and lipid membranes was studied by using scanning supercritical angle fluorescence microscopy. The biological response to elucidated changes in lipid membrane structure/characteristics under ZnO or TiO 2 NP influence was tested by fluorescence correlation spectroscopy. It was found the significant reduction of lipids diffusion mobility, which can be explained as a result of lipid-ZnO aggregates binding, depending on ZnO concentration. The TiO 2 has a little effect on lipids diffusion mobility.

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Section: Zno and Tio 2 Np's Interaction With Slbsupporting

confidence: 80%

Effect of Zinc Oxide and Titanium Dioxide Nanoparticles on Supported Lipid Bilayers

Grinceviciute¹,

Verdes²,

Snitka³

2015

JNMR

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“…Metal nanoparticles are also finding application in various other fields, i.e., catalysis and sensors [7][8][9]. However, it is also recognized that nanoparticles may have many undesirable and unforeseen effects on the environment and in the ecosystem [10,11].…”

Section: Introductionmentioning

confidence: 99%

Strain specificity in antimicrobial activity of silver and copper nanoparticles

Chatterjee²,

et al. 2008

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“…catalysis and sensors as mentioned before (126)(127)(128). However, their undesirable and unforeseen effects on the environment and in the ecosystem should not be ignored (129,130). The antibacterial effect of silver and copper nanoparticles was also investigated on Escherichia coli, Bacillus subtilis and Staphylococcus aureus (131).…”

Section: Metal Nanoparticles As Antisalmonellosis Agentsmentioning

confidence: 99%