Uptake of 3-[125I]iodo-α-methyl-l-tyrosine into colon cancer DLD-1 cells: characterization and inhibitory effect of natural amino acids and amino acid-like drugs

N-ω-chloroacetyl-l-ornithine, a new competitive inhibitor of ornithine decarboxylase, induces selective growth inhibition and cytotoxicity on human cancer cells versus normal cells

“…NCAO is an amino acid derivative that may be incorporated into the cells by several ATSs that have enhanced expression in cancer cells. The principal ATSs in cancer cells are ASCT2, LAT1 and ATB0,+, which have the appropriate characteristics for transporting NCAO because they have broad substrate specificity and participate in the transport of several drugs 62,64,[66][67][68] . Furthermore, a variety of drug transporters are expressed in HepG2 cells, including OATPs (organic anion transporting polypeptides) 69,70 and OCTs (organic cation transport) 71,72 .…”

Divergent expression of L-type amino acid transporter 1 during uterine cervical carcinogenesis

“…invasive capability of human tumor cells by controlling their transport activity via functionally distinct carrier systems [20,21]. Alternatively, association of LAT1 expression with angiogenesis in non-small cell lung cancer has been proposed because it correlated with the expression of vascular endothelial growth factor [22]. Furthermore, LAT1 expression has been demonstrated to be correlated with metastasis in various carcinomas [23].…”

Characterization of the microbiome of nipple aspirate fluid of breast cancer survivors

“…Using PICRUSt, the picked OTUs were normalized to their copy numbers and their pathway abundances inferred from the Kyoto Encyclopedia of Genes and Genomes (KEGG)58. PICRUSt identified a total of 328 KEGG pathways and 6909 bacterial genes, of which we pre-selected 18 pathways to reduce false discovery rate from multiple hypothesis testing; the pathways were selected based on previous nutritional and microbiome studies in relation to colon cancer2021222324252627. The selected 18 pathways were normalized to the sample with the lowest abundance, which was at a sampling depth of 26359.…”