Uptake by vascular smooth muscle cells plays an important role in targeting of lipid microspheres incorporating prostaglandin E1 into a thickened intima

Accumlation of lipoprostaglandin E1 at the anastomotic region after systemic application

“…PGE1 is employed as a vasodilator because of its potent vasodilating effect 2, 3, 7. Currently, two PGE1 preparations are widely used.…”

“…As a fluorescence label for lipoprostaglandin E1, 1, 1'‐dioctadecyl‐1, 3, 3', 3'‐tetramethyl‐indocarbocyanine (DiI) was used. DiI‐labeled lipo‐PGE1 and lipid microsphere (LM) as described in the report by Chino et al2, 3 were prepared by Taisho Pharmaceutical, Tokyo, Japan.…”

“…To infuse drugs, a 24‐F catheter was placed in the jugular vein. Immediately after the anastomosis was completed, DiI‐labeled lipo‐PGE1 was infused at 20 μg/kg/h for 2 hours (92 μl/min) following the reported method 2, 3…”

“…Even through various successful reconstructions using free tissue transfer has been reported, complete prevention of vascular compromise remains impossible 1. Lipoprostaglandin E1, in which prostaglandin E1 (PGE1) is incorporated into lipid microsphere, has lately attracted considerable attention as a vasodilating agent because its effect is more persistent and potent than free form PGE1 2. Chino et al reported a marked accumulation of lipoprostaglandin E1 (lipo‐PGE1) in a rat balloon‐injured common carotid artery,2 suggesting that lipo‐PGE1 selectively accumulates in mechanically injured vascular regions such as recipient vessel and vascular pedicle.…”

“…Lipoprostaglandin E1, in which prostaglandin E1 (PGE1) is incorporated into lipid microsphere, has lately attracted considerable attention as a vasodilating agent because its effect is more persistent and potent than free form PGE1 2. Chino et al reported a marked accumulation of lipoprostaglandin E1 (lipo‐PGE1) in a rat balloon‐injured common carotid artery,2 suggesting that lipo‐PGE1 selectively accumulates in mechanically injured vascular regions such as recipient vessel and vascular pedicle. If lipo‐PGE1 also acts on anastomotic region, lipo‐PGE1 may be available as a vasodilating agent for microsurgery.…”