Uptake and impacts of polyvinylpyrrolidone (PVP) capped metal oxide nanoparticles on <i>Daphnia magna</i>: role of core composition and acquired corona

Briffa, Sophie Marie; Nasser, Fatima; Valsami-Jones, Eugénia; Lynch, Iseult

doi:10.1039/c8en00063h

Cited by 33 publications

(25 citation statements)

References 40 publications

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“…It is extremely likely that these secreted biomolecules can adsorb onto NM surfaces creating an evolving eco‐corona thereby affecting the stability, identity and toxicity of the NMs toward D. magna . Indeed, it has been shown that both amino and carboxylic acid functionalized PS NMs and polyvinylpyrrolidone‐capped ZnO and CeO 2 NMs agglomerate when incubated in conditioned medium, with longer incubation times leading to larger NM sizes which increased their uptake by D. magna and resultant toxicity . Given that zooplankton such as D. magna feed on algae, it is important to understand the potential role of algal secretions also in NM eco‐coronas.…”

Section: The Eco‐coronamentioning

confidence: 99%

Nanomaterials in the Environment Acquire an “Eco‐Corona” Impacting their Toxicity to Daphnia Magna—a Call for Updating Toxicity Testing Policies

2019

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Nanomaterials (NMs) are particles with at least one dimension between 1 and 100 nm and a large surface area to volume ratio, providing them with exceptional qualities that are exploited in a variety of industrial fields. Deposition of NMs into environmental waters during or after use leads to the adsorption of an ecological (eco-) corona, whereby a layer of natural biomolecules coats the NM changing its stability, identity and ultimately toxicity. The eco-corona is not currently incorporated into ecotoxicity tests, although it has been shown to alter the interactions of NMs with organisms such as Daphnia magna (D. magna). Here, the literature on environmental biomolecule interactions with NMs is synthesized and a framework for understanding the eco-corona composition and its role in modulating NMs ecotoxicity is presented, utilizing D. magna as a model. The importance of including biomolecules as part of the current international efforts to update the standard testing protocols for NMs, is highlighted. Facilitating the formation of an eco-corona prior to NMs ecotoxicity testing will ensure that signaling pathways perturbed by the NMs are real rather than being associated with the damage arising from reactive NM surfaces "acquiring" a corona by pulling biomolecules from the organism's surface.novel and unique qualities that are not traditionally exhibited by bulk material of the same composition. NMs have been at the core of novel research for two decades and are incorporated into products spanning a range of industrial fields. For example, NMs properties are exploited in cancer research, such as the utilization of surface plasmon resonance properties of gold (Au) NMs; here the NMs are conjugated to antibodies complementary to antigens on cancer cells and are thereby internalized, following which oscillation of the Au electron cloud at a specific wavelength of light converts the absorbed light into localized heat to specifically destroy cancer cells. [1] Another example is exploitation of the antimicrobial properties of silver (Ag) NMs which undergo high dissolution to release Ag + ions [2] and where the dissolution site, rate (and thus toxicity) can be adjusted depending on the surface coating. [3] Considering that NMs are becoming so widely used, their release into the environment is inevitable. Despite this, considerably less research has focused on the implications of NMs on environmental organisms, especially under realistic conditions, than on development of their applications. NMs may enter freshwater systems from industrial effluent, where, for example, the concentrations of zinc oxide (ZnO) NMs, widely used in sunscreens and paints, in river waters has been found to be as high as 150 ng L −1 , [4] while gold (Au) NMs excreted following use in medical applications into surface waters have been predicted to be 470 pg L −1 [5] With deposition of NMs into environmental waters increasing, concerns regarding the potential for toxicity posed by NMs have demanded action, although the standard testing approaches h...

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Section: The Eco‐coronamentioning

confidence: 99%

Nanomaterials in the Environment Acquire an “Eco‐Corona” Impacting their Toxicity to Daphnia Magna—a Call for Updating Toxicity Testing Policies

2019

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“…Uptake of NPs is a crucial factor in assessing the effects of NPs [12]. When Ag NPs are associated with algae, it is possible for them to transfer up the food web [49].…”

Section: Introductionmentioning

confidence: 99%

The toxicity of coated silver nanoparticles to the alga Raphidocelis subcapitata

et al. 2020

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The use of silver nanoparticles (AgNPs) is growing exponentially, especially in consumer products due to their excellent antimicrobial properties. However, concerns are growing on their possible negative effects on environmental and human health. AgNPs from consumer products enter aquatic ecosystems where their physicochemical properties including surface functionalization are critical to their impact on aquatic organisms. The effects of AgNPs coated with three different ligands; tyrosine (T-AgNP), epigallocatechin gallate (E-AgNP) and curcumin (C-AgNP) and Ag + ions on the freshwater green alga Raphidocelis subcapitata were investigated. Stability tests of AgNPs revealed that the coating significantly affects the fate and behaviour of AgNPs. All types of AgNPs tested and ionic silver were found to be toxic to the alga and differential growth inhibition of algae were observed from differently coated AgNPs, with the 48 h EC 50 of C-AgNPs, T-AgNPs and E-AgNPs being 0.155, 0.163 and 0.243 mg L −1 , respectively, in comparison with 0.051 mg L −1 for Ag + ions. Associated Ag in the algae increased with increased concentrations of all AgNPs and Ag + ions and the toxicity positively correlated to the associated Ag content in algae. The antioxidant enzymes glutathione S-transferase and catalase were activated in algal cells by the AgNPs and Ag + ions, but a consistent difference in response was not identified with different concentrations of NPs. This study shows the effects of the surrounding environment and surface functionalization of AgNPs on algae highlighting the importance of considering them in environmental risk assessment of AgNPs.

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“…50,51,55 This could lead to unforeseen toxicities if the POPs form part of a dynamic corona which may then "unload" into various organisms which are normally exposed at lower doses based on equilibrium partitioning, or indeed are not exposed at all to these pollutants in normal settings. 35 Importantly using a common freshwater organism model it is possible to compliment the metabolite corona data with the protein corona from the same organism; 5,150 such studies with other model organisms may help pave the way to uncover similarities in behavior between the two corona classes, particularly with organisms from different environments.…”

Section: Metabolite Eco-coronamentioning

confidence: 99%

The rise of the nanomaterial metabolite corona, and emergence of the complete corona

Chetwynd

Lynch

2020

Environ. Sci.: Nano

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Uptake and impacts of polyvinylpyrrolidone (PVP) capped metal oxide nanoparticles on Daphnia magna: role of core composition and acquired corona

Abstract: A key hypothesis in nanosafety assessment is that the NP core chemistry and eco-corona are primary factors controlling toxicity.

Cited by 33 publications

References 40 publications

Nanomaterials in the Environment Acquire an “Eco‐Corona” Impacting their Toxicity to Daphnia Magna—a Call for Updating Toxicity Testing Policies

Nanomaterials in the Environment Acquire an “Eco‐Corona” Impacting their Toxicity to Daphnia Magna—a Call for Updating Toxicity Testing Policies

The toxicity of coated silver nanoparticles to the alga Raphidocelis subcapitata

The rise of the nanomaterial metabolite corona, and emergence of the complete corona

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