Uptake and efflux of polycyclic aromatic hydrocarbons byTetrahymena pyriformis: Evidence for a resistance mechanism

Effects of triclosan and triclocarban on the growth inhibition, cell viability, genotoxicity and multixenobiotic resistance responses of Tetrahymena thermophila

“…Tetrahymena represent an ecologically relevant animal group and a valuable model frequently used for assessing toxicity of contaminants. The MXR system in Tetrahymena was firstly demonstrated by Bamdad et al (1997Bamdad et al ( , 1999. So far, a total of 165 ABC transporter genes in the T. thermophila macronuclear genome were identified.…”

Applications of Flow Cytometry to Clinical Microbiology

“…They demonstrated the importance of iron for parasite growth and showed that FCM provides a simple and reliable means of antimalarial drug susceptibility testing. Analyzing environmental samples, Bamdad et al (16) used FCM to test the uptake and efflux of several polycyclic aromatic hydrocarbons in Tetrahymena spp. in an attempt to obtain evidence of a resistance mechanism.…”

P-gp expression in brown trout erythrocytes: evidence of a detoxification mechanism in fish erythrocytes

“…In these two models, P-gp expression was clearly induced in a dose-dependent manner, after exposure to different concentrations of various classes of PAHs561112.…”

“…In reality, P-gp belongs to the evolutionarily conserved family of the ATP-binding cassette (ABC) proteins found in practically all living organisms, whether prokaryotic4 or eukaryotic35678910111213. P-gp acts as xenobiotics efflux pump transporting various substrates out of cells.…”

“…Vinca alkaloids, actinomycin D, taxol, antracyclines), calcium channel blockers (e.g. verapamil)3561112141516171819202122. Due to this property, P-gp is involved in the natural defence mechanisms of cells, tissues and organs, and forms an essential part of the innate defence system known as “chemo-immunity”3.…”