Uptake and distribution of boron in rats: Interaction with ethanol and hexobarbital in the brain

Magour, S.; Schramel, P.; Ovcar, J.; Mäser, H.

doi:10.1007/bf01056357

Cited by 17 publications

(3 citation statements)

References 19 publications

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“…In studies with yearling beef heifers, the percentage of filtered boron that was reabsorbed decreased as the amount of filtered boron increased (33). In another animal study, female rats consuming water very high in boron (100 mg/L) for 21 d had increased plasma boron concentrations without accumulating boron in liver and brain (34). Our group found boron to be taken up by RAW264.7 and HL60 cells against a boron concentration gradient (35).…”

Section: Discussionmentioning

confidence: 60%

Boron Concentrations in Milk from Mothers of Exclusively Breast-Fed Healthy Full-Term Infants Are Stable during the First Four Months of Lactation,

Hunt¹,

Butte²,

Johnson³

2005

The Journal of Nutrition

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Because boron is a bioactive element that satisfies several of the criteria for essentiality in humans, the aim of the present work was to determine the profile of boron metabolism in human milk during the first 4 mo of lactation. The concentration of boron and other minerals was determined in archived milk collected (1980-84) 1 time/mo for 4 mo from lactating mothers of full-term, exclusively breast-fed infants living in Houston, TX. A linear model (treating month as a continuous variable) indicated that B concentrations were stable (P = 0.14) between mo 1 [3.88 +/- 0.6 mumol (42 +/- 6.5 microg)/L milk] and 4 [3.24 +/- 0.6 micromol (35 +/- 6.5 microg)/L milk, mean +/- SEM]. Mg concentrations increased slightly over time (1.18 +/- 0.09 to 1.36 +/- 0.09 mmol/L, P < 0.0001), whereas Ca concentrations decreased slightly (7.01 +/- 0.29 to 6.68 +/- 0.29 mmol/L milk, P < 0.02) and Zn decreased substantially (0.04 +/- 0.004 to 0.02 +/- 0.004 mmol/L milk, P < 0.0001). Similarities in findings reported here and earlier (from samples collected in St. John's, Newfoundland) provide further evidence that boron may be metabolically regulated. Future investigations of boron regulatory mechanisms should focus on metabolism of bone as the major storage site of B and kidney excretion, the major excretory route for B.

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Section: Discussionmentioning

confidence: 60%

Boron Concentrations in Milk from Mothers of Exclusively Breast-Fed Healthy Full-Term Infants Are Stable during the First Four Months of Lactation,

Hunt¹,

Butte²,

Johnson³

2005

The Journal of Nutrition

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“…In comparison, boron levels in bone were still three times control values up to 32 weeks after exposure ceased (Chapin et al, 1997). Magour et al (1982, as reported in IPCS, 1998 determined the tissue levels of boron in Wistar rats administered 20 mg boron/kg bw/day as sodium tetraborate (equivalent to 177 mg sodium tetraborate/kg bw/day and 114 mg boric acid/kg bw/day) in drinking water. Exposure was initiated at 3 weeks of age and continued for 21 days.…”

Section: Distributionmentioning

confidence: 80%

Scientific Opinion on the re‐evaluation of boric acid (E 284) and sodium tetraborate (borax) (E 285) as food additives

2013

EFS2

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The Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion re‐evaluating the safety of boric acid (E 284) and sodium tetraborate (borax) (E 285) as food additives in the EU. These additives are authorised in EU for use as preservatives of sturgeon eggs (caviar) up to a maximum concentration of 4 g boric acid/kg. Previous evaluations have been performed by the Scientific Committee for Food (SCF) in 1979, 1988 and 1992, Joint FAO/WHO Expert Committee on Food Additives (JECFA) in 1962, EFSA (2004, 2005a, b, 2012) and TemaNord (2002). The Panel concluded that boric acid and sodium tetraborate do not raise concern for genotoxicity. Feeding studies in rats, mice and dogs have demonstrated that the male reproductive system is adversely affected by boric acid and sodium tetraborate. The adverse effects found with boric acid are similar to those obtained from other borates indicating that the boron is the toxicologically active species. The data on toxicokinetics do not indicate differences between laboratory animals and humans. The Panel concluded that based on the NOAEL of 9.6 mg boron/kg bw/day, derived from a developmental toxicity study in rats, and application of an uncertainty factor of 60, a group ADI of 0.16 mg boron/kg bw/day can be established. Exposure to boron from its use as food additive at the highest is 0.04 mg boron/kg bw/day for children, 0.01 mg boron/kg bw/day for adolescents, 0.01 mg boron/kg bw/day for adults, and 0.01 mg boron/kg bw/day for the elderly. Exposure estimates to boron from its use as food additive at the highest 95th percentile for consumers only, for children, adolescents, adults and the elderly would be 0.56, 0.37, 0.13 and 0.15 mg/kg bw/day, respectively. The Panel concluded that it is unlikely that a regular exceedance of the ADI occurs.

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“…Other investigators have also reported a remarkably narrow range of boron concentrations in whole blood from subjects with unknown dietary histories (Clarke et al 1987). In female rats, supplementation with high amounts of boron (9.25 mmol/L water) for 21 days, caused an increase in plasma boron concentrations but an undefined homeostatic mechanism concurrently eliminated any excess of boron from the liver and brain against their own concentration gradients (Magour et al 1982). In yearling beef heifers, the percent of filtered boron reabsorbed by the kidneys decreased significantly with increased boron intake (Green and Weeth 1977).…”

Section: Evidence For Boron Homeostatic Controlmentioning

confidence: 92%

Dietary Boron: Evidence for Essentiality and Homeostatic Control in Humans and Animals

Hunt

2007

Advances in Plant and Animal Boron Nutrition

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Uptake and distribution of boron in rats: Interaction with ethanol and hexobarbital in the brain

Cited by 17 publications

References 19 publications

Boron Concentrations in Milk from Mothers of Exclusively Breast-Fed Healthy Full-Term Infants Are Stable during the First Four Months of Lactation,

Boron Concentrations in Milk from Mothers of Exclusively Breast-Fed Healthy Full-Term Infants Are Stable during the First Four Months of Lactation,

Scientific Opinion on the re‐evaluation of boric acid (E 284) and sodium tetraborate (borax) (E 285) as food additives

Dietary Boron: Evidence for Essentiality and Homeostatic Control in Humans and Animals

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