Dietary Boron: Evidence for Essentiality and Homeostatic Control in Humans and Animals

Hunt, Curtiss D.

doi:10.1007/978-1-4020-5382-5_25

Cited by 21 publications

(13 citation statements)

References 69 publications

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“…Typical symptoms of B deficiency in root nodules are enlarged and irregularly shaped walls with several components abnormally assembled. Nodules devoid of B have cell walls without covalently bound hydroxyproline-/proline-rich glycoproteins (Bonilla et al 1997), and show changes in the content and distribution of pectic polysaccharides (Redondo-Nieto et al 2003, 2007. In our experiments, a fraction containing RGII extracted from +B nodules was able to associate with Amberlite (Fig.…”

Section: Discussionmentioning

confidence: 48%

“…In bacteria, B is a component of the signalling molecule autoinducer AI-2 implicated in quorum sensing (Chen et al 2002). Moreover, the discovery of in vitro binding of borate to adenylates (Ralston & Hunt 2001) or to cyclic ribose (Ricardo et al 2004), along with the evidence of B essentiality in animals (reviewed by Hunt 2007) and the interaction with plant membrane-associated proteins (Wimmer et al 2009), point to important roles of B beyond RGII cross-linking in cell walls.…”

Section: Introductionmentioning

confidence: 99%

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Ligands of boron in Pisum sativum nodules are involved in regulation of oxygen concentration and rhizobial infection

Reguera

Wimmer

Bustos

et al. 2010

Plant Cell & Environment

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Section: Discussionmentioning

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Ligands of boron in Pisum sativum nodules are involved in regulation of oxygen concentration and rhizobial infection

Reguera

Wimmer

Bustos

et al. 2010

Plant Cell & Environment

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“…Such enzymes include serine proteases (e.g., those released by activated leukocytes) and vitamin D-24-hydroxylase (the enzyme that catalyzes the first step in the inactivation of vitamin D 3 ). Thus "boron" has anti-inflammatory action and also potentiates the effects of vitamin D 3 , promoting Ca 2ϩ reabsorption and increasing insulin sensitivity (402,403). Furthermore, boric acid is a ligand for molecules such as ribose, S-adenosylmethionine, ATP, ADP, cAMP, NAD ϩ , and NADH, although the consequences of boric acid binding for the bioactivity of these molecules has not been investigated (402,403).…”

Section: Physiological Rolesmentioning

confidence: 97%

The Divergence, Actions, Roles, and Relatives of Sodium-Coupled Bicarbonate Transporters

Parker

Boron

2013

Physiological Reviews

246

262

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The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1-3), five Na(+)-coupled HCO3(-) transporters (NCBTs), and two other unusual members (AE4, BTR1). In this review, we mainly focus on the five mammalian NCBTs-NBCe1, NBCe2, NBCn1, NDCBE, and NBCn2. Each plays a specialized role in maintaining intracellular pH and, by contributing to the movement of HCO3(-) across epithelia, in maintaining whole-body pH and otherwise contributing to epithelial transport. Disruptions involving NCBT genes are linked to blindness, deafness, proximal renal tubular acidosis, mental retardation, and epilepsy. We also review AE1-3, AE4, and BTR1, addressing their relevance to the study of NCBTs. This review draws together recent advances in our understanding of the phylogenetic origins and physiological relevance of NCBTs and their progenitors. Underlying these advances is progress in such diverse disciplines as physiology, molecular biology, genetics, immunocytochemistry, proteomics, and structural biology. This review highlights the key similarities and differences between individual NCBTs and the genes that encode them and also clarifies the sometimes confusing NCBT nomenclature.

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“…Due to the effective homeostatic control of plasma B levels, which involves gastrointestinal absorption and renal excretion, animal tissue B concentrations are generally kept steady and B toxicity in animals and humans is rare [1,4,5]. Although molecular mechanisms responsible for this control are not clear [6], a previously cloned putative "bicarbonate" transporter [7] was recently shown [8] to be a Na + -coupled borate transporter (NaBC1, SLC4A11).…”

Section: Introductionmentioning

confidence: 98%

“…Although organic B may be inaccessible to animals, inorganic B such as borates, due to their high solubility, are readily absorbed across gastrointestinal epithelia and quickly distributed throughout body fluids and soft tissues [1,3,4]. Boron in plasma is primarily and rapidly excreted in urine; therefore, the concentration of urinary B can mirror the actual B intake and a higher B intake does not significantly increase the plasma B level [1,5].…”

Section: Introductionmentioning

confidence: 98%

Dietary Supplementation of Boron Differentially Alters Expression of Borate Transporter (NaBCl) mRNA by Jejunum and Kidney of Growing Pigs

Liao

Monegue

Lindemann

et al. 2010

Biol Trace Elem Res

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Inorganic boron (B), in the form of various borates, is readily absorbed across gastrointestinal epithelia. Although there is no stated B requirement, dietary B supplementation is thought to positively affect animal growth and metabolism, including promotion of bone strength and cell proliferation. Because of effective homeostatic control of plasma B levels, primarly by renal excretion, B toxicity in animals and humans is rare. The mechanisms responsible for improved animal performance and borate homeostasis are incompletely understood. Although a Na+-coupled borate transporter (NaBC1) has been identified, the effect of dietary B supplementation on expression of NaBCl has not been evaluated. An experiment was conducted with growing pigs to determine if NaBC1 mRNA was expressed by small intestinal epithelia and kidney of growing barrows and whether dietary B (as borate) supplementation would affect expression of NaBC1 mRNA. A concomitant objective was to test the hypothesis that B supplementation of a phosphorus (P)-deficient diet would improve calcium, phosphorus, or nitrogen retention. Twenty-four crossbred growing barrows (body weight=74.0±9.8 kg) were selected and used in a randomized complete block design experiment with a total of eight blocks and three B supplementation treatments (n=8/treatment). A typical corn-soybean meal basal diet (calculated to contain 41 mg intrinsic B/kg) was formulated to meet or exceed nutrient requirements, except for P, and fed to all pigs for 12 days. The basal diet plus 0, 50, or 100 mg/kg of B (prilled sodium borate pentahydrate, Na₂B₄O₇·5H₂O) was then fed for 18 more days. Feces and urine were collected during days 6 to 16 of the B supplementation, and pigs were killed for collection of jejunal and ileal epithelia and kidney tissue. Real-time reverse transcription-PCR analysis revealed that NaBC1 mRNA was expressed by these tissues, a novel finding for jejunal and ileal epithelia. Boron supplementation increased jejunal, but decreased, renal NaBC1 mRNA expression, relative to the 0 mg/kg treatment. The finding that NaBC1 mRNA is regulatable by dietary B is novel. That B supplementation evoked opposite effects on jejunal and kidney NaBC1 mRNA expression indicates that transcriptional regulation of NaBC1 expression may constitute a part of the homeostatic control of B metabolism. In contrast to its effect on NaBC1 mRNA expression, B supplementation did not affect total tract digestibility or retention of phosphorus, calcium, or nitrogen.

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Dietary Boron: Evidence for Essentiality and Homeostatic Control in Humans and Animals

Cited by 21 publications

References 69 publications

Ligands of boron in Pisum sativum nodules are involved in regulation of oxygen concentration and rhizobial infection

Ligands of boron in Pisum sativum nodules are involved in regulation of oxygen concentration and rhizobial infection

The Divergence, Actions, Roles, and Relatives of Sodium-Coupled Bicarbonate Transporters

Dietary Supplementation of Boron Differentially Alters Expression of Borate Transporter (NaBCl) mRNA by Jejunum and Kidney of Growing Pigs

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