Uptake and biotransformation of structurally diverse brominated flame retardants in zebrafish (<i>Danio rerio</i>) after dietary exposure

Nyholm, Jenny Rattfelt; Norman, Arne; Norrgren, Leif; Haglund, Peter; Andersson, Patrik L.

doi:10.1897/08-302.1

Cited by 64 publications

(52 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The absence of BDE-209 in fish specimens is generally explained by the combined effects of lower bioavailability associated with its high octanol-water partition coefficient (log K ow ¼ 12.1) and its high molecular weight (m/z ¼ 959 amu) (Stapleton et al, 2004b(Stapleton et al, , 2006. However, in contrast to earlier reports, several recent studies have detected BDE-209 in some wild and experimental fish (Munschy et al, 2011;Nyholm et al, 2009;Wan et al, 2013). The reason of detecting different levels of BDE-209 may be due to the different efficiencies of uptake, elimination and metabolism for BDE-209 among various fish species.…”

Section: Pbde Congener Profiles In the Brain Compared With Other Tissuesmentioning

confidence: 93%

“…The reason of detecting different levels of BDE-209 may be due to the different efficiencies of uptake, elimination and metabolism for BDE-209 among various fish species. Laboratory studies have reported the uptake efficiencies of BDE-209 were 1.4% ± 0.9% for juvenile common sole (Munschy et al, 2011), 0.62% for zebrafish (Nyholm et al, 2009), 0.44% for rainbow trout (Stapleton et al, 2006), and 0.5% ± 0.2% for Chinese sturgeon (Wan et al, 2013), respectively. In vitro metabolism studies also revealed that 65.6% of BDE-209 was biotransformed in liver microsomes of Chinese sturgeon which was lower than those in rainbow trout and common carp.…”

Section: Pbde Congener Profiles In the Brain Compared With Other Tissuesmentioning

confidence: 99%

See 1 more Smart Citation

Accumulation of polybrominated diphenyl ethers in the brain compared with the levels in other tissues among different vertebrates from an e-waste recycling site

Zhao

Qin

et al. 2016

Environmental Pollution

View full text Add to dashboard Cite

a b s t r a c tThis study aimed to investigate the accumulation of polybrominated diphenyl ethers (PBDEs) in the brain compared with that in other tissues among different vertebrates. We collected mice, chickens, ducks, frogs, and fish from an e-waste recycling region in Taizhou, China, and measured PBDE concentrations in brain, liver and muscle tissues. The levels of PBDE in the tissues of mice, chickens, ducks, frogs and fish ranged 0.45e206, 0.06e18.8, 1.83e112, 2.75e108, and 0.02e32.0 ng/g wet weight, respectively. Preferential distribution in the liver and muscle relative to the brain was observed for PBDEs in mice, chickens, ducks and frogs. However, a high retention in the brain compared to the liver and muscle was observed in fish. Comparison of the brain/liver concentration (B/L) ratios revealed differences in PBDEs accumulation in the brain among these vertebrates. PBDEs accumulation in the brain was greatest in fish, followed by frogs, while the lowest accumulation occurred in the brains of mammals and birds. The findings apparently coincided with the evolution of the blood-brain barrier (BBB) across vertebrates, i.e. the BBB of fish might be less efficient than those of mammals, birds and amphibian. Low brominated congeners (such as BDE-28, BDE-47 and BDE-99) were predominant in the brains of investigated vertebrates, whereas BDE-209 was most abundant in liver and muscle tissues of mice, chickens and ducks. Significant differences in B/L ratios among PBDE congeners were found in both mice and chickens (p < 0.05). Particularly in mice, the B/L ratios of PBDE congeners presented a declining trend with increased bromine number. Our findings suggested that low brominated congeners might have a higher capacity to penetrate the BBB and accumulate in the brain, whereas high brominated congeners such as BDE-209 might have less potency to pass through the barrier. Further experimental studies are needed to confirm our findings.

show abstract

Section: Pbde Congener Profiles In the Brain Compared With Other Tissuesmentioning

confidence: 93%

Section: Pbde Congener Profiles In the Brain Compared With Other Tissuesmentioning

confidence: 99%

Accumulation of polybrominated diphenyl ethers in the brain compared with the levels in other tissues among different vertebrates from an e-waste recycling site

Zhao

Qin

et al. 2016

Environmental Pollution

View full text Add to dashboard Cite

show abstract

“…Another potential BFR and PBDE metabolite is tribromoanisole (TBA) (Nyholm et al 2009). It was detected in all analysed eels and tissue types with the highest average concentrations of several ng g -1 ww (Table 2).…”

Section: Metabolism and Continued Uptakementioning

confidence: 99%

Maternal transfer of emerging brominated and chlorinated flame retardants in European eels

Sühring

Freese²,

Schneider

et al. 2015

Science of The Total Environment

View full text Add to dashboard Cite

Maternal transfer of emerging brominated and chlorinated flame retardants in European eels AbstractThe European eel (Anguilla anguilla) is regarded as a critically endangered species. Scientists are in agreement that the "quality of spawners" is a vital factor for the survival of the species. This quality can be impaired by parasites, disease and pollution. Especially endocrine disrupting organic chemicals pose a potential threat to reproduction and development of offspring.To our knowledge, the findings in this publication for the first time describe maternal transfer of contaminants in eels. We analysed the concentrations of in total 53 polybrominated diphenyl ethers (PBDEs) and their halogenated substitutes in muscle, gonads and eggs of artificially matured European eels and in muscle and gonads of untreated European eels that were used for comparison. We found evidence that persistent organic pollutants such as PBDEs, as well as their brominated and chlorinated substitutes are redistributed from muscle tissue to gonads and eggs. Concentrations ranged from 0.001 ng g -1 ww for sum Dechlorane metabolites (DPMA, aCL 10 DP, aCl 11 DP) to 2.1 ng g -1 ww for TBA in eggs, 0.001 ng g -1 ww for Dechlorane metabolites to 9.4 ng g -1 ww for TBA in gonads and 0.002 ng g -1 ww for Dechlorane metabolites to 54 ng g -1 ww for TBA in muscle tissue.Average egg muscle ratios (EMRs) for compounds detectable in artificially matured eels from both Schlei Fjord and Ems River ranged from 0.01 for Dechlorane 602 (DDC-DBF) to 10.4 for PBEB. Strong correlations were found between flame retardant concentrations and lipid content in the analysed tissue types, as well as transfer rates and octanol-water partitioning

show abstract

“…Rattfelt Nyholm et al (2009) studied the uptake of DBE-DBCH in zebrafish (Danio rerio) dietary exposed to a mixture of eleven different BFRs at concentrations of either 1 or 100 nmol/g feed for 42 days, followed by an elimination period of 14 days. They found a DBE-DBCH uptake efficiency of 60 % and estimated the half-life to be 0.9-1.3 days.…”

Section: Hazard Identificationmentioning

confidence: 99%

Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food

2012

EFS2

View full text Add to dashboard Cite

EFSA was asked to deliver a scientific opinion on brominated flame retardants (BFRs) other than PBDEs, PBBs, HBCDDs, TBBPA and brominated phenols and their derivatives. The BFRs that are the subject of the current opinion, were classified in groups termed "emerging" and "novel" BFRs. Information on 17 emerging and 10 novel BFRs was collected. The information varied widely for these BFRs. There is a lack of experimental data on physico-chemical characteristics, stability/reactivity and current use and production volume of all the emerging and novel BFRs. Due to the very limited information on occurrence, exposure and toxicity, the CONTAM Panel could not perform a risk characterisation for any of the BFRs considered. Instead, an attempt was made to identify those BFRs that could be a potential health concern and should be considered first for future investigations. For this purpose the Panel first evaluated the available experimental data on occurrence in food, behaviour in the environment and toxicity. Secondly, a modelling exercise was performed focussing on the potential of the emerging and novel BFRs for persistence in the environment and for their possible bioaccumulation potential. There is convincing evidence that tris(2,3-dibromopropyl) phosphate (TDBPP) and dibromoneopentyl glycol (DBNPG) are genotoxic and carcinogenic, warranting further surveillance of their occurrence in the environment and in food. Based on the limited experimental data on environmental behaviour, 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) and hexabromobenzene (HBB) were identified as compounds that could raise a concern for bioaccumulation. For the modelling exercise, the CONTAM Panel selected two environmental characteristics, overall persistence and potential for bioaccumulation, as being most relevant to provide insight into the possibility that emerging or novel BFRs The less well known and less studied BFRs, subject of the current opinion, were grouped into two classes, referred to herein as "emerging" and "novel" BFRs. Emerging BFRs are defined as chemicals which are applied as flame retardants and that have been identified in any environmental compartment, in wildlife, in food or in humans. It should be noted that the definition for the emerging BFRs, used in this opinion, does not imply that there is evidence for an increasing trend in the concentration of these BFRs in the environment, in food or in human samples. Novel BFRs are defined as chemicals applied as flame retardants, with confirmed presence in materials and/or goods in concentrations above 0.1 %, but not identified in environmental samples, wildlife, food or humans. In total, information on 27 BFRs, of which 17 were identified as "emerging" and 10 as "novel", was collected by the CONTAM Panel, and it was noted that the available information varied widely for the various individual BFRs.In general, there is a lack of experimental data on physico-chemical characteristics and stability/reactivity for all the emerging and novel BFRs. This sometimes hampered ...

show abstract

Uptake and biotransformation of structurally diverse brominated flame retardants in zebrafish (Danio rerio) after dietary exposure

Cited by 64 publications

References 28 publications

Accumulation of polybrominated diphenyl ethers in the brain compared with the levels in other tissues among different vertebrates from an e-waste recycling site

Accumulation of polybrominated diphenyl ethers in the brain compared with the levels in other tissues among different vertebrates from an e-waste recycling site

Maternal transfer of emerging brominated and chlorinated flame retardants in European eels

Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food

Contact Info

Product

Resources

About