Upregulation of Tumor Necrosis Factor Alpha-Induced Protein 3 mRNA in Mild Psoriasis Vulgaris

Upregulation of tumor necrosis factor alpha‐induced protein 3 interacting protein 1 mRNA in psoriasis vulgaris

“…It is worth to note that the products of the TNFAIP3 and TNIP1 genes (A20 and ABIN1, respectively) functionally bind to each other, an interaction that may synergistically impede NF-κB signaling and negatively regulate inflammation [5]. Interestingly, in our previous study, TNFAIP3 seems to be the immediate early gene for defense reactions in the pathogenesis of psoriasis vulgaris, as its mRNA expression was significantly up-regulated in lesions compared to normal-appearing skin in the "mild" psoriasis group [4]. Moreover, our results showed an upward trend of TNIP1 mRNA levels from the mild to the severe subgroup.…”

“…The proteins encoded by these two genes can bind to each other and function as a "brake" on NF-κB signaling [2]. Recent studies demonstrated that TNFAIP3 mRNA is highly expressed in patients with mild psoriasis vulgaris, but not in those with severe disease [3,4]. Since TNIP1 may facilitate the function of TNFAIP3 in the negative feedback regulation of NF-κB activation [5], the corresponding transcript levels of TNIP1 in psoriasis vulgaris were investigated in this study.…”

“…Primers used in real-time PCR were as follows: TNIP1 forward, 5′-AAAGGAGATCCAGCGGCTCAAC-3′; TNIP1 reverse, 5′-TTCTCCTCATTCATGCGCTCAC-3′; POLR2A forward, 5′-GCAGAGAAGCTGGTGCTCCGTA-3′; and POLR2A reverse, 5′-CAGCATGTTGGACTCGATGCAG -3′. SYBR Green real-time PCRs of TNIP1 and POLR2A were performed, as described previously [4]. Gene expression levels in the different groups were compared using the paired t-test and ANOVA test.…”

A Review of Possible Triggering or Therapeutic Effects of Antimicrobial Vaccines on Psoriasis

“…In a few studies, it was reported that expression of TNFAIP3 mRNA was significantly higher in patients with mild psoriasis than in the patients with severe psoriasis, suggesting that TNFAIP3 gene may be a 'target' molecule for psoriasis therapy [52,53]. There are also reported studies, which are mentioned below, about the usage of vaccines on psoriasis.…”

Design and characterization of a chimeric multiepitope construct containing CfaB, heat‐stable toxoid, CssA, CssB, and heat‐labile toxin subunit B of enterotoxigenic Escherichia coli: a bioinformatic approach

“…Recently, Zhang and co‐workers constructed a candidate vaccine against porcine ETEC that is composed of LT toxoid (LT192R→G) and STp (ST variant pig, porcine) toxoid (STp11N→K, STp12P→F, and STp13A→Q) that was effective in the production of neutralizing antibodies. In another study, they incorporated LT and ST epitopes in a fimbriae‐encoding gene for the production of a fusion vaccine candidate . Furthermore, You and co‐workers used LTB and ST toxoid in the construction of a trivalent fusion protein in which ST toxicity was reduced with mutagenesis at one of disulfide bridge–forming cysteines in the ST structure.…”