Upregulation of the long noncoding RNA UCA1 affects the proliferation, invasion, and survival of hypopharyngeal carcinoma

Qian, Yue; Liu, Dayu; Cao, Shengda; Tao, Ye; Wei, Dongmin; Li, Wenming; Li, Guojun; Pan, Xinliang; Lei, Dapeng

doi:10.1186/s12943-017-0635-6

Cited by 58 publications

(39 citation statements)

References 26 publications

(24 reference statements)

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“…Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive tumour arising from the outer layer (epithelium) of the upper aerodigestive tract and accounts for 5%‐15% of all head and neck squamous cell carcinoma (HNSCC) . Due to the recent improvements in modern comprehensive treatment strategies including surgery, chemotherapy and radiotherapy, the 5‐year survival rate for patients with early‐stage HSCC is as high as 70%; however, the majority of HSCCs are diagnosed at an advanced stage (stage III or IV), with a 5‐year survival rate of about 35%, and HSCC patients are also vulnerable to relapse.…”

Section: Introductionmentioning

confidence: 99%

Effect of up‐regulation of circMATR3 on the proliferation, metastasis, progression and survival of hypopharyngeal carcinoma

Wang

Wei

et al. 2020

J Cellular Molecular Medi

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Increasing number of circular RNAs (circRNAs) have been reported to play important role in gene regulation, carcinogenesis and pathogenesis in various cancers.However, the biological functions and underlying molecular mechanisms of circRNAs in hypopharyngeal squamous cell carcinoma (HSCC) remain elusive. Thus, secondary circRNA-seq profiling was performed to identify the differentially expressed circR-NAs between HSCC tissues and adjacent normal tissues, and the expression level of circMATR3 (derived from human gene matrin3 (MATR3), has_circRNA_0008922) was confirmed by qRT-PCR. Proliferation of HSCC cells was detected by cell counting kit-8 (CCK8) assay, apoptosis and the cell cycle were analysed by flow cytometry, and the migration and invasion of HSCC cells was determined by transwell assay.Bioinformatics analysis was conducted to predict possible pathways and potential miRNA targets of circMATR3. We found that circMATR3 was up-regulated in HSCC tissues, and abundant circMATR3 expression was markedly correlated with late T classification, advanced clinical stage, greater lymph node metastasis, and poor prognosis. Furthermore, knock-down of circMATR3 significantly inhibited proliferation, migration and invasion of HSCC cells, whereas silencing of circMATR3 induced cell apoptosis. Our analysis predicted that circMATR3 may participate in cancer-related pathways by serving as miRNA sponges. In conclusion, our findings first identified the oncogenic roles of circMATR3 in promoting the progression of HSCC and demonstrated that circMATR3 may be a novel prognostic marker and therapeutic target for HSCC. K E Y W O R D S circMATR3, circular RNAs, hypopharyngeal squamous cell carcinoma, progression S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Wang Z, Wei P, Wei D, et al. Effect of up-regulation of circMATR3 on the proliferation, metastasis, progression and survival of hypopharyngeal carcinoma. J Cell

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Section: Introductionmentioning

confidence: 99%

Effect of up‐regulation of circMATR3 on the proliferation, metastasis, progression and survival of hypopharyngeal carcinoma

Wang

Wei

et al. 2020

J Cellular Molecular Medi

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“…These RNAs regulate gene expression through multiple approaches at the transcriptional, posttranscriptional, and epigenetic levels, such as by recruiting transcription factors or directly binding to proteins, RNA, and DNA (Bergmann & Spector, ; Chen, ; Johnson, ). Noteworthy, abnormal expression of lncRNAs play a vital role in the development and progression of cancers, which might serve as biomarkers for tumor diagnosis and prognostic (Bergmann and Spector, ; Chang et al, ; Chen, ; Meng et al, ; Qian et al, ).…”

Section: Introductionmentioning

confidence: 99%

TUSC7: A novel tumor suppressor long non‐coding RNA in human cancers

Shi

2018

Journal Cellular Physiology

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Accumulating evidences has shown that tumor suppressor candidate 7 (TUSC7) as a putatively tumor suppressor gene in various tumors. The low-expression of TUSC7 is related to poor prognosis, and increased the proliferation rate of tumor cells. Over-expression of TUSC7 could suppress tumor cell proliferation, migration, invasion, and colony formation, suggesting that TUSC7 might be a diagnostic and prognostic biomarker, as well as therapeutic target. In this review, we summarized the molecular mechanism and clinical significance of TUSC7 in tumorigenesis, tumor progression, and prognosis.

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“…Aberrant expression of some lncRNAs has been demonstrated to be associated with tumor progression, as well as with the clinical outcome in various cancers (Xue et al, 2016;Qian et al, 2017;Su et al, 2017;Zhuo and Kang., 2017). Until recently, lncRNA PCAT-1 has been considered as an potential diagnostic/ prognostic biomarker in a wide variety of neoplasms, including ovarian cancer (Qian et al, 2017;Cao et al, 2014), prostate cancer (Karlsson et al, 2016;Chandra Gupta et al, 2017), colorectal cancer (Qi et al, 2013;, non-small-cell lung cancer (NSCLC), and esophageal squamous cell carcinoma (ESCC) (Shi et al, 2015). Lnc-PCAT-1 was firstly known as a prostatespecific regulator of cell proliferation correlated with the degree of cell differentiation.…”

Section: Discussionmentioning

confidence: 99%

Biological and Clinical Relevance of Long Non-Coding RNA PCAT-1 in Cancer, A Systematic Review and Meta-Analysis

Talebi

Akbari

Mobini

et al. 2019

Asian Pac J Cancer Prev

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Long non-coding RNA (lncRNA) prostate cancer associated transcript 1 (PCAT-1) has been identified as a potential biomarker for the diagnosis and prognosis of various cancers. We performed this systematic review and meta-analysis to evaluate the role of dysregulation as well as the biological and clinical significance of lnc-PCAT-1 for predicting the malignancy status in several cancers. Two independent reviewers conducted an extensive search in electronic databases of Medline, Embase, Scopus, Web of Science and PubMed until the December of 2017. Five articles investigating the clinical significance of lncRNA PCAT-1, including 996 patients, were analyzed. Our results revealed that the increased PCAT-1 expression was related to overall survival (OS) (HR = 1.9, 95% CI: 1.13-3.18, P=0.015). Also, pooled results of the diagnostic data analysis demonstrated that PCAT-1 has a sensitivity of 0.59 and specificity of 0.66 for cancer diagnosis. Moreover, pooled area under curve was 0.62 (95% CI: 0.58–0.69). This meta-analysis revealed that lncRNA PCAT-1 could be served as a potential diagnostic and prognostic biomarker in various solid tumors.

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Upregulation of the long noncoding RNA UCA1 affects the proliferation, invasion, and survival of hypopharyngeal carcinoma

Cited by 58 publications

References 26 publications

Effect of up‐regulation of circMATR3 on the proliferation, metastasis, progression and survival of hypopharyngeal carcinoma

Effect of up‐regulation of circMATR3 on the proliferation, metastasis, progression and survival of hypopharyngeal carcinoma

TUSC7: A novel tumor suppressor long non‐coding RNA in human cancers

Biological and Clinical Relevance of Long Non-Coding RNA PCAT-1 in Cancer, A Systematic Review and Meta-Analysis

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