Upregulation of SKA3 enhances cell proliferation and correlates with poor prognosis in hepatocellular carcinoma

Tang, Jianxin; Liu, Jing; Li, Jinjun; Liang, Ziming; Zeng, Kaining; Li, Haibo; Zhao, Zhenlin; Zhou, Li; Jiang, Nan

doi:10.3892/or.2021.7999

Cited by 9 publications

(8 citation statements)

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“…Each individual aspect of TNM is termed as a category: T category describes the primary tumor site and size; N category describes the regional lymph node involvement; M category describes the presence or otherwise of distant metastatic spread. Gene enrichment analysis (GSEA) was used to understand the differentially functional enrichment pathways of samples with different types ( Tang et al, 2021 ). In order to explore the characteristics of immune microenvironment of different types of samples, the R package “limma” was used to filter the differences in immune cell infiltration of different types of samples ( Li Z. et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

The Prognostic Value and Immune Landscapes of a m6A/m5C/m1A-Related LncRNAs Signature in Head and Neck Squamous Cell Carcinoma

Wang

Yang

Ming

et al. 2021

Front. Cell Dev. Biol.

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Background: N6-methyladenosine (m6A), 5-methylcytosine (m5C) and N1-methyladenosine (m1A) are the main RNA methylation modifications involved in the progression of cancer. However, it is still unclear whether m6A/m5C/m1A-related long non-coding RNAs (lncRNAs) affect the prognosis of head and neck squamous cell carcinoma (HNSCC).Methods: We summarized 52 m6A/m5C/m1A-related genes, downloaded 44 normal samples and 501 HNSCC tumor samples with RNA-seq data and clinical information from The Cancer Genome Atlas (TCGA) database, and then searched for m6A/m5C/m1A-related genes co-expressed lncRNAs. We adopt the least absolute shrinkage and selection operator (LASSO) Cox regression to obtain m6A/m5C/m1A-related lncRNAs to construct a prognostic signature of HNSCC.Results: This prognostic signature is based on six m6A/m5C/m1A-related lncRNAs (AL035587.1, AC009121.3, AF131215.5, FMR1-IT1, AC106820.5, PTOV1-AS2). It was found that the high-risk subgroup has worse overall survival (OS) than the low-risk subgroup. Moreover, the results showed that most immune checkpoint genes were significantly different between the two risk groups (p < 0.05). Immunity microenvironment analysis showed that the contents of NK cell resting, macrophages M2, and neutrophils in samples of low-risk group were significantly lower than those of high-risk group (p < 0.05), while the contents of B cells navie, plasma cells, and T cells regulatory (Tregs) were on the contrary (p < 0.05). In addition, patients with high tumor mutational burden (TMB) had the worse overall survival than those with low tumor mutational burden.Conclusion: Our study elucidated how m6A/m5C/m1A-related lncRNAs are related to the prognosis, immune microenvironment, and TMB of HNSCC. In the future, these m6A/m5C/m1A-related lncRNAs may become a new choice for immunotherapy of HNSCC.

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Section: Methodsmentioning

confidence: 99%

The Prognostic Value and Immune Landscapes of a m6A/m5C/m1A-Related LncRNAs Signature in Head and Neck Squamous Cell Carcinoma

Wang

Yang

Ming

et al. 2021

Front. Cell Dev. Biol.

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“…The inhibition of cell proliferation, induction of cell cycle arrest in the G1/S phase, as well as in vitro and in vivo tumorigenesis, were significantly connected to the downregulation of SKA3. In addition, SKA3 downregulation led to decreased cyclin D1 expression and retinoblastoma phosphorylation, and increased p21 level, suggesting that SKA3 mediates HCC cell cycle and progression ( 23 ). In lung adenocarcinoma, SKA3 promoted metastasis by binding to EGFR and activating the PI3K/AKT signaling pathway ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

“…progression (23). In lung adenocarcinoma, SKA3 promoted metastasis by binding to EGFR and activating the PI3K/AKT signaling pathway (24).…”

Section: B C Amentioning

confidence: 99%

SKA1/2/3 is a biomarker of poor prognosis in human hepatocellular carcinoma

Song

He²,

Ji³

et al. 2022

Front. Oncol.

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BackgroundSpindle and kinetochore-associated complex subunits 1–3 (SKA1–3) stabilize the kinetochore-attached spindle microtubules in metaphase. Due to the dysregulation in multiple cancers, SKA1–3 is considered a predictor for the prognosis of the patients. However, the potential clinical applications of SKA1–3, particularly in hepatocellular carcinoma (HCC) prognosis and progression, have completely unknown yet.MethodsFor the analysis of SKA1–3 expression and applications in clinics in HCC patients, several databases, such as STRING, UALCAN, GEO, and TCGA, were searched. In addition, the underlying mechanisms of SKA for the regulation of HCC occurrence, development, and progression were also explored.ResultsCompared to the normal controls, HCC patients showed dramatically elevated SKA1–3 expression at the mRNA level, and the values of the area under the curve (AUC) were 0.982, 0.887, and 0.973, respectively. Increased SKA1–3 expression levels were associated with the clinical stage, age, body mass index, tumor grade, tissue subtype, and Tp53 mutation status in HCC patients. The analyses of Kyoto Encyclopedia of Genes and Genome (KEGG) and Gene ontology (GO) demonstrated that SKA1–3 are enriched mainly in the Fanconi anemia, homologous recombination, spliceosome, DNA replication, and cell cycle signaling pathways. The hub genes, such as CDK1, CCNB1, CCNA2, TOP2A, BUB1, AURKB, CCNB2, BUB1B, NCAPG, and KIF11, were identified in protein–protein interactions (PPIs). The expression levels of hub genes were increased in HCC patients and predictive of a poor prognosis. Finally, the expression levels of SKA1–3 were determined using the GEO database.ConclusionsSKA1–3 are potential prognostic biomarkers of and targets for HCC. In addition, SKA1–3 may affect HCC prognosis via the Fanconi anemia pathway, homologous recombination, spliceosome, DNA replication, and cell cycle signaling pathway.

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“…In addition, high expression of the SKA complex was closely correlated with tumor stage, patient race, tumor grade, and TP53 mutation status 57 . For gene set enrichment analysis, SKA3 was found to be correlated with BENPORATH proliferation gene set signaling pathways, cell cycle, DNA repair, and the P53 signaling pathway 54 , 58 , 59 . Moreover, Yu et al .…”

Section: Role Of Ska3 In Human Cancermentioning

confidence: 99%

SKA3 targeted therapies in cancer precision surgery: bridging bench discoveries to clinical applications – review article

Feng,

Wang,

Xiao

et al. 2024

International Journal of Surgery

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Spindle and kinetochore-associated complex subunit 3 (SKA3) is a microtubule-binding subcomplex of the outer kinetochore which plays a vital role in proper chromosomal segregation and cell division. Recently, SKA3 have been demonstrated its oncogenic role of tumorigenesis and development in cancers. In this review, we comprehensively deciphered SKA3 in human cancer from various aspects, including bibliometrics, pan-cancer analysis and narrative summary. We also provided top 10 predicted drugs targeting SKA3. We proposed that SKA3 was a potential target and brought new therapeutic opportunities for cancer patients.

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Upregulation of SKA3 enhances cell proliferation and correlates with poor prognosis in hepatocellular carcinoma

Cited by 9 publications

References 0 publications

The Prognostic Value and Immune Landscapes of a m6A/m5C/m1A-Related LncRNAs Signature in Head and Neck Squamous Cell Carcinoma

The Prognostic Value and Immune Landscapes of a m6A/m5C/m1A-Related LncRNAs Signature in Head and Neck Squamous Cell Carcinoma

SKA1/2/3 is a biomarker of poor prognosis in human hepatocellular carcinoma

SKA3 targeted therapies in cancer precision surgery: bridging bench discoveries to clinical applications – review article

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