Upregulation of Ryanodine Receptor Calcium Channels (RyR2) in Rats with Induced Diabetes after 4 Weeks of High Intensity Interval Training

Bigi, Mohammad Ali Babaee; Faramarzi, Hossein; Gaeini, Abbas Ali; Ravasi, Ali Asghar; Izadi, Mohammad Reza; Delfan, Maryam; Izadi, E

doi:10.17795/icrj-10(1)1

Cited by 3 publications

(6 citation statements)

References 21 publications

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“…Moreover, the disturbed mitochondrial performance is involved in the DCM pathophysiological mechanisms, which could be regulated with PGC-1

[ 19 ]. Other signaling pathway activations like the AMPK in response to energetic demand and calcium-based myocardial performance mediated by RyR2 and SERCA2 are among the implicated parameters in DCM [ 10 , 25 ]. The exercise protocols might alleviate cardiovascular complications and mitigate DCM incidence by preventing pathological cardiac remodeling.…”

Section: Discussionmentioning

confidence: 99%

“…Severe systolic dysfunction was also demonstrated in diabetic patients, which might be related to the alteration of gene expression involved in adjusting intracellular calcium homeostasis. The changeover of calcium-based activities such as RyR2 and SERCA2a sensitivity change in diabetesis somewhat responsible for the myocardial contraction disturbance [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…AMP-activated protein kinase ( AMPK ) preserves ATP by retrieving the ratio of NAD+/NADH and excluding catabolic pathways, which will be turned on by reducing intracellular ATP levels [ 9 ]. Along the progression of DCM, the expression of some genes like the

ATPase pump of the sarcoplasmic reticulum ( SERCA ) and ryanodine receptors ( RyR ), which recreate an influential contribution in the normal operation of the heart muscle, might be disrupted [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Activation of AMPK and improvement of glucose metabolism following exercise training are mentioned in animal and clinical trial studies [ 9 ]. Regulation of RyR and SERCA , as the main contributors in the removal of intracellular calcium, improved with exercise training [ 10 ]. Due to its hypoglycemic effect, metformin is one of the most commonly used oral first-line drugs in managing diabetes-induced hyperglycemia.…”

Section: Introductionmentioning

confidence: 99%

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Endurance Exercise Prevented Diabetic Cardiomyopathy through the Inhibition of Fibrosis and Hypertrophy in Rats

Shabab,

Mahmoudabady,

Gholamnezhad

et al. 2024

Rev. Cardiovasc. Med.

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Background: Exercise training could be essential in preventing pathological cardiac remodeling in diabetes. Therefore, the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) singly or plus metformin on diabetes-induced cardiomyopathy were investigated in this study. Methods: Forty-nine Wistar rats (male) were recruited. Seven groups of animals were treated for six weeks as control, diabetes, MICT (15 m/min, 40 min/day), HIIT (20 m/min, 40 min/day), metformin (300 mg/kg), HIIT+metformin (Met-HIIT), and MICT+metformin (Met-MICT). The metformin was orally administered with an intragastrical needle, and the exercised rats were trained (5 days/week) with a motorized treadmill. Metabolic parameters, echocardiographic indices, histopathology evaluation, and assessment of gene expression connected with cardiac fibrosis, hypertrophy, mitochondrial performance, and intracellular calcium homeostasis were investigated. Results: Our results demonstrated that all the interventions prevented weight loss and enhanced heart weight/body weight ratio and fasting plasma glucose in diabetic rats. Both types of exercise and their metformin combinations improved diabetic animals’ echocardiography indices by enhancing heart rate, fractional shortening (FS), ejection fraction (EF) and reducing end-systolic and end-diastolic diameter of left ventricular (LVESD and LVEDD). Gene expression of atrial natriuretic peptide ( ANP ), brain natriuretic peptide ( BNP ), transforming growth factor ( TGF ) - , and collagen increased in the diabetes group. In contrast, the gene expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha ( PGC-1 ), AMP-activated protein kinase ( AMPK ), ryanodine receptors ( RyR ), and ATPase pump of the sarcoplasmic reticulum ( SERCA ) was reduced in diabetic animals. Exercise training alone or in combination with metformin reversed these changes. Moreover, diabetes-induced cardiac fibrosis was ameliorated in treated groups. All indicators of diabetic cardiomyopathy were improved more in the Met-HIIT group than in other groups. Conclusions: Exercise training, notably with metformin combination, alleviated diabetes-induced cardiac complications. The beneficial effects of exercise could be related to improving pathological cardiac remodeling and enhancing cardiac function.

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“…Moreover, the disturbed mitochondrial performance is involved in the DCM pathophysiological mechanisms, which could be regulated with PGC-1

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Endurance Exercise Prevented Diabetic Cardiomyopathy through the Inhibition of Fibrosis and Hypertrophy in Rats

Shabab,

Mahmoudabady,

Gholamnezhad

et al. 2024

Rev. Cardiovasc. Med.

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“…It is also reported that susceptibility of myocardial cells to calcium in inactive people or patients with cardiac functional disorder reduces. This reduction is associated with downregulation of hydroxypyridine and ryanodine receptors as well as myocardial sarco/endoplasmic reticulum Ca 2+ ATPase pumps (SERCA) (35). After sporting activities based on Cardiac Rehab, these recipients are upregulated and thus, the susceptibility of the myocardial cells to calcium will increase; so, heart contractility power increases with each hit compared to before rehab program.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Various Cardiac Rehabilitation Programs on Cardiac Dimensions of Post-CABG Patients

Saiiari

Kashef

Adel

et al. 2017

Jentashapir J Helath Res

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Background: In the majority of cardiovascular diseases, cardiovascular structure changes in line with the type of disease. One of the goals of cardiac rehabilitation is the improvement of cardiac performance and reversibility of hypertrophied cardiac dimensions. The present research aimed to compare the effectiveness of various cardiac rehabilitation programs on cardiac dimensions of patients with post-coronary artery bypass grafting (CABG). Methods: In this semi-experimental research, among CABG patients, 40 males with cardiovascular disease after CABG operation were selected using purposeful sampling method and divided into 4 groups of 10 persons: 1) aerobic continuous training group; 2) aerobic interval + resistance training group; 3) aerobic continuous + resistance training group; and 4) control group. Trainings were held for eight weeks, three training sessions a week, and every session included aerobic trainings with intensity of 50% -85% of reserved heart rate and resistance trainings with 40% -60% of maximum repetition. One day before and one day after the training intervention, the investigated variables were measured using two-dimensional echocardiography. For statistical analysis, the

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Current advances in the study of diabetic cardiomyopathy: From clinicopathological features to molecular therapeutics (Review)

Sun

Zhou

et al. 2019

Mol Med Report

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The incidence of diabetes mellitus has become a major public health concern due to lifestyle alterations. Moreover, the complications associated with diabetes mellitus deeply influence the quality of life of patients. diabetic cardiomyopathy (dc) is a type of diabetes mellitus complication characterized by functional and structural damage in the myocardium but not accompanied by coronary arterial disease. currently, diagnosing and preventing dc is still a challenge for physicians due to its atypical symptoms. For this reason, it is necessary to summarize the current knowledge on dc, especially in regards to the underlying molecular mechanisms toward the goal of developing useful diagnostic approaches and effective drugs based on these mechanisms. There exist several review articles which have focused on these points, but there still remains a lot to learn from published studies. in this review, the features, diagnosis and molecular mechanisms of dc are reviewed. Furthermore, potential therapeutic and prophylactic drugs are discussed. Contents1. introduction 2. epidemiology and features of dc 3. diagnosis of dc 4. The pathogenesis of dc 5. The molecular mechanism of dc 6. Treatment of diabetic cardiomyopathy 7. conclusions

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Upregulation of Ryanodine Receptor Calcium Channels (RyR2) in Rats with Induced Diabetes after 4 Weeks of High Intensity Interval Training

Cited by 3 publications

References 21 publications

Endurance Exercise Prevented Diabetic Cardiomyopathy through the Inhibition of Fibrosis and Hypertrophy in Rats

Endurance Exercise Prevented Diabetic Cardiomyopathy through the Inhibition of Fibrosis and Hypertrophy in Rats

The Effect of Various Cardiac Rehabilitation Programs on Cardiac Dimensions of Post-CABG Patients

Current advances in the study of diabetic cardiomyopathy: From clinicopathological features to molecular therapeutics (Review)

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