Upregulation of miR-27a contributes to the malignant transformation of human bronchial epithelial cells induced by SV40 small T antigen

Wang, Q; Dc, Li; Zf, Li; Cx, Liu; Ym, Xiao; Zhang, B; Xd, Li; Zhao, Jian; Lp, Chen; Xm, Xing; Sf, Tang; Lin, Yingsong; Yd, Lai; Yang, Peipei; Jl, Zeng; Xiao, Qian; Xw, Zeng; Zn, Lin; Zhuang, Zerui; Zhuang, Shi‐Mei; Chen, W

doi:10.1038/onc.2011.103

Cited by 71 publications

(61 citation statements)

References 62 publications

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“…Recent data from Wang and colleagues support our results, thus firmly establishing miR27a as a bona fide regulator of FBW7. 24 Interestingly, Wang and collaborators show that miR-27a is involved in SV40-mediated increased DNA replication stress through suppression of FBW7 expression.…”

Section: Discussionmentioning

confidence: 99%

“…The fact that miR-27a is a negative regulator of several tumor suppressors, [20][21][22] including FBW7, and is overexpressed in different malignancies, suggests that it may act as a novel oncogene. [22][23][24] In order to explore if the regulation of FBW7 by miR-27a is relevant to human cancer, we analyzed the expression of miR-27a in pediatric B-ALL. As can be seen in Figure 7A, miR-27a is overexpressed, as compared to normal bone marrow cells and CD34 + B cells, in five out of six subtypes of B-ALL.…”

Section: Discussionmentioning

confidence: 99%

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MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression

Lerner¹,

Lundgren²,

Akhoondi³

et al. 2011

Cell Cycle

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression

Lerner¹,

Lundgren²,

Akhoondi³

et al. 2011

Cell Cycle

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“…It has been identified as an oncogene in various cancers, including NSCLC (Tian et al, 2014;Wang et al, 2011). It is involved in cell proliferation and apoptosis, metastasis and drug resistance in cancer cell lines by specially binding to 3'-UTR of its targeted genes (Li et al, 2014;Tian et al, 2014;Noratto et al, 2013).…”

Section: Rs895819 Within Mir-27a Might Be Involved In Development Of mentioning

confidence: 99%

Rs895819 within miR-27a Might be Involved in Development of Non Small Cell Lung Cancer in the Chinese Han Population

Yan²,

Yang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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MicroRNA-27a (miR-27a) is deemed to be an oncogene that plays an important role in development of various cancers, and single nucleotide polymorphism (SNP) of miR-27a can influence the maturation or aberrant expression of hsa-miR27a, resulting in increased risk of cancer and poor prognosis for non-small cell lung cancer (NSCLC). This study aimed to assess the effects of rs895819 within miR-27a on susceptibility and prognosis of NSCLC patients in 560 clinical confirmed cases and 568 healthy check-up individuals. Adjusted odds/hazard ratios (ORs/HRs) and 95% confidential intervals (CIs) were calculated to evaluate the association between rs895819 and the risk and prognosis of NSCLC. The results showed that allele A and genotype GG of rs895819 were significantly associated with an increased risk of NSCLC (38.9% vs 30.8%, adjusted OR=1.26, 95%CI=1.23-1.29 for allele G vs A; 18.1% vs 11.7%, adjusted OR=1.67, 95%CI=1.59-1.75 for genotype GG vs AA). Moreover, positive associations were also observed in dominant and recessive models (53.7% vs 49.9%, adjusted OR=1.17, 95%CI=1.13-1.20 for GG/AG vs AA; 18.1% vs 11.7%, adjusted=1.65, 95%CI=1.58-1.73). However, no significant association was found between rs895819 and the prognosis of NSCLC in genotype, dominant and recessive models. These results suggested that miR-27a might be involved in NSCLC carcinogenesis, but not in progression of NSCLC. The allele G, genotype GG and allele G carrier (GG/AG vs AA) of rs895819 might be genetic susceptible factors for NSCLC. Further multi-central, large sample size and well-designed prospective studies as well as functional studies are warranted to verify our findings.

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“…MiR-27a also has been found to serve as an oncogene in gastric cancer, promoting the growth of gastric cells via inhibiting the expression of prihibitin (Liu et al, 2009). In addition, it has also been reported in studies of lung and breast cancers (Li et al, 2010;Wang et al, 2011) Although it has been nearly 10 years since miR-27 was firstly found, there are few research articels on miR-27 and its function in glioblastoma.…”

Section: Introductionmentioning

confidence: 99%

AntagomiR-27a Targets FOXO3a in Glioblastoma and Suppresses U87 Cell Growth in Vitro and in Vivo

Ge¹,

Sun²,

Jin³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Objective: To study the effect of the antagomiR-27a inhibitor on glioblastoma cells. Methods: The miR27a expression level in specimens of human glioblastoma and normal human brain tissues excised during decompression for traumatic brain injury was assessed using qRT-PCR; The predicted target gene of miR-27a was screened out through bioinformatics databases, and the predicted gene was verified using genetic report assays; the effect of antagomiR-27a on the invasion and proliferation of glioma cells was analyzed using MTT assays and 5-ethynyl-2'-deoxyuridine (EdU) labeling. A xenograft glioblastoma model in BALB-c nude mice was established to detect the effect of antagomiR-27a on tumour growth. Results: qRT-PCR results showed that miR-27a significantly increased in specimens from glioblastoma comparing with normal human brain tissues. Th miR-27a inhibitor significantly suppressed invasion and proliferation of glioblastoma cells. FOXO3a was verified as a new target of miR-27a by Western blotting and reporter analyzes. Tumor growth in vivo was suppressed by administration of the miR-27a inhibitor. Conclusion: MiR-27a may be up-regulated in human glioblastoma, and antagomiR-27a could inhibit the proliferation and invasion ability of glioblastoma cells.

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Upregulation of miR-27a contributes to the malignant transformation of human bronchial epithelial cells induced by SV40 small T antigen

Cited by 71 publications

References 62 publications

MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression

MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression

Rs895819 within miR-27a Might be Involved in Development of Non Small Cell Lung Cancer in the Chinese Han Population

AntagomiR-27a Targets FOXO3a in Glioblastoma and Suppresses U87 Cell Growth in Vitro and in Vivo

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