Upregulation of miR-155 regulates group 2 innate lymphoid cells by targeting c-maf in allergic rhinitis

Zhu, Yaqiong; Liu, Yuehui; Zhu, Xinhua; Wang, Zhi; Wang, Meiqun

doi:10.1016/j.ejphar.2020.173564

Cited by 13 publications

(13 citation statements)

References 38 publications

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“…In Group 2 innate lymphoid cells (ILC2), miR-155 targets the 3′-UTR of the Maf mRNA and increased the production of IL-5, IL-9, and IL-13 Th2 cytokines in culture. Moreover, the treatment of mice with induced-allergic rhinitis with miR-155 antagomir significantly increased the expression of c-Maf and reduced allergic symptoms ( 166 ). Furthermore, another report described that c-MAF binding to the Il10 promoter is restricted by jarid2 in miR-155-deficient Th17 cells, emphasizing the importance of this network in regulating IL-10 expression.…”

Section: Discussion: Maf Association With Other Regulatorsmentioning

confidence: 99%

Molecular Mechanisms Driving IL-10- Producing B Cells Functions: STAT3 and c-MAF as Underestimated Central Key Regulators?

et al. 2022

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Regulatory B cells (Bregs) have been highlighted in very different pathology settings including autoimmune diseases, allergy, graft rejection, and cancer. Improving tools for the characterization of Bregs has become the main objective especially in humans. Transitional, mature B cells and plasma cells can differentiate into IL-10 producing Bregs in both mice and humans, suggesting that Bregs are not derived from unique precursors but may arise from different competent progenitors at unrestricted development stages. Moreover, in addition to IL-10 production, regulatory B cells used a broad range of suppressing mechanisms to modulate the immune response. Although Bregs have been consistently described in the literature, only a few reports described the molecular aspects that control the acquisition of the regulatory function. In this manuscript, we detailed the latest reports describing the control of IL-10, TGFβ, and GZMB production in different Breg subsets at the molecular level. We focused on the understanding of the role of the transcription factors STAT3 and c-MAF in controlling IL-10 production in murine and human B cells and how these factors may represent an important crossroad of several key drivers of the Breg response. Finally, we provided original data supporting the evidence that MAF is expressed in human IL-10- producing plasmablast and could be induced in vitro following different stimulation cocktails. At steady state, we reported that MAF is expressed in specific human B-cell tonsillar subsets including the IgD+ CD27+ unswitched population, germinal center cells and plasmablast.

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Section: Discussion: Maf Association With Other Regulatorsmentioning

confidence: 99%

Molecular Mechanisms Driving IL-10- Producing B Cells Functions: STAT3 and c-MAF as Underestimated Central Key Regulators?

et al. 2022

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“…A recently published animal study showed that miR-155 upregulation significantly increased the rates of nasal rubbing and sneezing and levels of IL-4, IL-5, IL-9, and IL-13. Also, pathological alterations were exacerbated after the intranasal administration with miR-155 agomir and were improved after miR-155 antagomir administration [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…MiRNA-155 is thought to be involved in the pathogenesis of AR since its expression is upregulated in multiple immune cell lineages including T cells, B lymphocytes, mast cells, fibroblasts, macrophages, and dendritic cells [13][14][15]. e role of miR-155 in AR has been confirmed in studies by Suojalehto et al (2013) [16], Zhu et al (2019) [17], and Zhu et al [18].…”

Section: Introductionmentioning

confidence: 93%

Role of MicroRNA-155 as a Potential Biomarker for Allergic Rhinitis in Children

Hammad

Nabil

Elbehedy

et al. 2021

Canadian Respiratory Journal

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Background. Allergic rhinitis (AR) is an inflammatory state categorized by a disturbance of immunoregulatory mechanisms. MicroRNA-155 (miRNA-155) has an essential role in regulating gene expression and can mediate the allergic TH2 process. Objective. In this study, we aimed to evaluate the role of miR-155 as a biomarker in AR and correlate its level with the total nasal symptom score (TNSS) and the levels of serum interleukin-4 (IL-4). Methods. This study included 90 children: 45 with pollen-induced AR and 45 healthy controls. Serum miR-155 expression levels were measured using quantitative real-time PCR. Human IL-4 ELIZA kits were used for the semiquantitative detection of the serum levels of IL-4. Receiver operating characteristic (ROC) curves were used to determine the best cutoff values for the studied parameters for the diagnosis of AR. Results. The demographic characteristics of the two groups were matched with respect to age and sex. The AR case group included 23 (51.1%) males and 22 (48.9%) females, while the control group included 24 (53.3%) males and 21 (46.7%) females. The miR-155 level was increased in the serum of children with pollen-induced AR compared with controls (mean difference = 2.8, p < 0.001 ). A significant positive correlation between the serum expression level of miR-155 and TNSS in children with AR was detected (r = 0.494, p < 0.001 ). However, no significant correlation was identified between the expression of miR-155 and that of IL-4. At a cutoff value of 1.09, the sensitivity of miR-155 as a biomarker for AR was 100%, and the specificity was 71.1%. Conclusion. MiR-155 expression levels were elevated in the serum of AR children. Therefore, miR-155 could be used as a biomarker in AR diagnosis.

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“…Allergic rhinitis pathological changes and signs in mice were worsened after miR-155 agonist and ameliorated after miR-155 antagonist administration [48]. This regulation appears to occur via changes in c-Maf, a transcription factor that regulates T cell IL-4 expression and secretion, the differentiation of naive T cells into Th2 cells and the differentiation and development of T follicle helper cells and regulatory T cells [49]. Similar changes occurred with another microRNAs…”

Section: Treatment Implicationsmentioning

confidence: 96%

Innate and adaptive immunity in allergic airway disease

Scadding

2021

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewThis article explores recent findings on the involvement of innate immunity in allergic airways disease, concentrating on allergic rhinitis. Recent findingsWe speculate on the ways in which environmental influences act to initiate inflammation and on how these may have altered in recent decades. Improved understanding of the mechanisms involved may reveal future possibilities for therapy.

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Upregulation of miR-155 regulates group 2 innate lymphoid cells by targeting c-maf in allergic rhinitis

Cited by 13 publications

References 38 publications

Molecular Mechanisms Driving IL-10- Producing B Cells Functions: STAT3 and c-MAF as Underestimated Central Key Regulators?

Molecular Mechanisms Driving IL-10- Producing B Cells Functions: STAT3 and c-MAF as Underestimated Central Key Regulators?

Role of MicroRNA-155 as a Potential Biomarker for Allergic Rhinitis in Children

Innate and adaptive immunity in allergic airway disease

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