Upregulation of circ‑ASPH contributes to glioma cell proliferation and aggressiveness by targeting the miR‑599/AR/SOCS2‑AS1 signaling pathway

Interaction between Non-Coding RNAs and Androgen Receptor with an Especial Focus on Prostate Cancer

“…Lentivirus-mediated up-regulation of miR-449a has been shown to further suppress the proliferation of these cells via the induction of cell cycle arrest [58]. ↓ proliferation, migration and invasion [64] In addition, miR-9-5p has been identified as a suppressor of AR expression in breast cancer. A feedback loop has been recognized between these genes in breast cancer cells, in which androgen agonists of AR can increase expression of miR-9-5p.…”

“…In glioma, the circ-ASPH/miR-599/AR/SOCS2-AS1 axis has been identified as a molecular mechanism for cancer progression. In fact, circ-ASPH could mediate this function by sponging miR-599 [64].…”

SOCS proteins and their roles in the development of glioblastoma (Review)

“…It has also been determined that the expression levels of SOCS3 and SOCS1 are the highest in central nervous system cells, such as microglia and astrocytes, and the abnormal expression of SOCS3 and SOCS1 is associated with the poor prognosis of GBM ( 25 ). Furthermore, previous studies have reported that other SOCS family members can change the phenotype of GBM cells via signaling pathways such as the JUN/microRNA (miRNA/miR)-494/SOCS6 ( 33 ) and miR-599/androgen receptor (AR)/SOCS2-antisense RNA 1 (AS1) signaling pathways ( 34 ). However, further in vivo and in vitro experiments must be performed.…”

“…It was previously demonstrated that methylation of the SOCS2 promoter may be associated with a poor GBM prognosis ( 50 ). The circular (circ)RNA-aspartyl/asparaginyl β-hydroxylase (circ-ASPH) can promote the invasion of GBM cells by targeting the miR-599/AR/SOCS2-AS1 signaling pathway ( 34 ). Furthermore, miR-296-3p is regulated by neurofibromatosis 2 (NF2) and enhances the invasiveness of GBM cells via the SOCS2/STAT3 signaling pathway.…”

“…However, SOCS proteins regulate GBM invasion and metastasis via numerous pathways. For example, circ-ASPH regulates the miR-599/AR/SOCS2-AS1 signaling pathway, which promotes glioma cell proliferation and invasiveness ( 34 ). It has also been reported that miR-296-3p is regulated by NF2 and enhances the invasiveness of GBM cells via the SOCS2/STAT3 signaling pathway ( 111 ).…”