Upregulated Interleukin-21 Receptor on B Cells Associated with the Downregulation of IgE in Patients with Allergic Rhinitis

Jen, Hsiao-Yu; Yang, Yao‐Hsu; Chiang, Bor‐Luen; Chuang, Ya Hui

doi:10.1089/jir.2014.0036

Cited by 9 publications

(4 citation statements)

References 38 publications

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“…Meanwhile, Hsiao-Yu et al observed high expression of IL-21 receptor on naive and memory B cells in AR patients. 34 This was in line with the high levels of IL-21 and IgE in serum in AR patients. IL-21 could drive more B cells to differentiate into plasma cells to secrete immunoglobulin, including IgE, which likely contributes to the pathogenesis of AR.…”

Section: Discussionsupporting

confidence: 74%

SLAMs Negatively Regulate IL-21 Production in Tfh-Like Cells from Allergic Rhinitis Patients

Yang

Geng

et al. 2021

JAA

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Background Allergic rhinitis (AR) is characterized by type I hypersensitivity that is mediated by IgE-induced humoral responses. Follicular helper T cells (Tfh) comprise the key helper T cell (Th) subset that promotes antibody production. Signaling lymphocytic activation molecules (SLAMs) participate in regulation of the differentiation and function of Tfh cells, but whether this regulation is involved in the pathogenesis of AR is unknown. Methods CD4+CXCR5+ Tfh-like cells from peripheral blood were detected by flow cytometry. The IL-21 and IgE levels in serum were measured by an ELISA. Blood CD4+CXCR5+ Tfh-like cells were sorted and cultured with anti-SLAM mAb in vitro. Results The frequencies of circulating CD4+CXCR5+ Tfh-like cells appeared virtually unchanged in AR patients, but the expression of SLAMs and SLAM-associated protein (SAP) on circulating Tfh-like cells was significantly decreased. Meanwhile, the level of serum IL-21 was increased in AR patients, and a negative correlation was found between the IL-21 level and SLAM or SAP expression on CD4+CXCR5+ T cells. Treatment with anti-SLAM mAb resulted in reduced IL-21 production by Tfh-like cells in vitro. Additionally, SLAM expression on B cells was significantly decreased, although the percentages of B cells were increased in AR patients. Conclusion SLAMs negatively regulate IL-21 production in CD4+CXCR5+ Tfh-like cells, which contributes to the pathogenesis of AR.

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Section: Discussionsupporting

confidence: 74%

SLAMs Negatively Regulate IL-21 Production in Tfh-Like Cells from Allergic Rhinitis Patients

Yang

Geng

et al. 2021

JAA

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“…Production of specific IgE, IL-4, and IL-5 was reduced in CD40 -/and Schistosoma mansoni egg antigeninduced AR mouse models [23]. IgE secretion by B cells was inhibited by promoting the combination of CD40L and IL-4 in patients with AR [24]. Recently, siRNA is used in studies of the role of CD40 in allergic inflammation.…”

Section: Mediators Of Inflammationmentioning

confidence: 99%

The Role of CD40 in Allergic Rhinitis and Airway Remodelling

Cheng

Zhou

Liu

et al. 2021

Mediators of Inflammation

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Background. Allergic rhinitis (AR) affects millions of people and is lack of effective treatment. CD40 is an important costimulatory molecule in immunity. However, few studies have focused on the role of CD40 in AR. Methods. In this study, we built mouse model of chronic AR. The mice were divided into the AR, control, intravenous CD40 siRNA, and nasal CD40 siRNA groups ( n = 6 each). We detected OVA-sIgE, IL-4, IL-5, IL-13, IL-10, IFN-γ, and TGF-β levels in serum and supernatant by ELISA, CD40+ splenic DCs, and Foxp3+ Tregs by flow cytometry and CD40 mRNA by RT2-PCR. We also used PAS and MT stains to assess tissue remodelling. Results. (1) The OVA-sIgE, IL-4, IL-5, and IL-13 levels in the serum or supernatant of nasal septal membrane of AR mice were significantly higher than control. After treated with CD40 siRNA, those indicators were significantly decreased. The IFN-γ, IL-10, and TGF-β levels in AR mice were significantly lower than that in control and were increased by administration of CD40 siRNA. (2) AR mice had significantly fewer Foxp3+ Tregs in the spleen than control mice. After treated with CD40 siRNA, AR mice had significantly more Foxp3+ Tregs. (3) AR mice exhibited a significantly higher CD40 mRNA levels than control. Administration of CD40 siRNA significantly reduced the CD40 mRNA level. (4) The AR mice showed significantly greater collagen deposition than the control in MT staining. Applications of CD40 siRNA significantly reduced the collagen deposition in AR mice. Conclusion. CD40 siRNA therapy shows promise for chronic AR as it significantly attenuated allergic symptoms and Th2-related inflammation and upregulated Foxp3+ Tregs. CD40 plays a role in tissue remodelling in AR, which can be inhibited by CD40 siRNA application.

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“…A decreased in IgE+ B cells proportion was found in AR patients after AIT without correlation between blood IgE+ B cells and circulating IgE levels [ 59 ]. There is evidence that IL-21 regulates IgE levels by binding to B cells in the AR associated immune response [ 60 ]. Regulatory B cells (B regs ) modulate inflammation by IL-10, IL-35 and TGF-ß secretion and are associated with allergen tolerance [ 61 ].…”

Section: Blood Cells In Armentioning

confidence: 99%

The impact of allergen exposure and specific immunotherapy on circulating blood cells in allergic rhinitis

Jordakieva

Jensen‐Jarolim²

2018

World Allergy Organization Journal

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Allergic rhinitis (AR) is an IgE-mediated inflammatory disease of the nasal mucosa with well described local immune responses during allergen exposure. The frequent association of AR with general extra-nasal symptoms and other allergic conditions, such as conjunctivitis and asthma, however, support a more systemic disease impact. In addition to acute elevation of soluble inflammatory mediators in periphery blood, a growing number of studies have reported changes in circulating blood cells after specific nasal allergen challenge or environmental allergen exposure. These findings imply an involvement of specific blood leukocyte subsets, thrombocytes and recently, erythrocytes. This review summarizes the circulating blood cell dynamics associated with allergen exposure in AR subjects reported so far. Additionally, the impact of therapy, particularly allergen-specific immunotherapy (AIT), the only currently available causal treatment reducing AR-related symptoms, is further considered in this context.

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Upregulated Interleukin-21 Receptor on B Cells Associated with the Downregulation of IgE in Patients with Allergic Rhinitis

Cited by 9 publications

References 38 publications

SLAMs Negatively Regulate IL-21 Production in Tfh-Like Cells from Allergic Rhinitis Patients

SLAMs Negatively Regulate IL-21 Production in Tfh-Like Cells from Allergic Rhinitis Patients

The Role of CD40 in Allergic Rhinitis and Airway Remodelling

The impact of allergen exposure and specific immunotherapy on circulating blood cells in allergic rhinitis

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