Upper Lobe Fibrosis in Ankylosing Spondylitis

A patient with ankylosing spondylitis and recurrent haemoptysis

“…Bone changes, consisting of symmetric marginal syndesmophytes ("bamboo spine"), are usually visible on the thoracic spine of patients with ankylosing spondylitis who have pleuropulmonary abnormalities. In the series of WOLSON and ROHWEDDER [1], apical fibrosis was found in two (4%) of 52 patients with typical skeletal radiological manifestations of ankylosing spondylitis.…”

“…Ankylosing spondylitis is a connective tissue disease of unknown pathogenesis [1][2][3]. Young males aged 20-40 yrs are the most commonly affected, 90% of whom are HLA-B27-positive [2,3].…”

Ankylosing spondylitis and adenocarcinoma of the lung

“…This was formerly thought to apply particularly to the squamous cell and oat cell types,"3 14 but there is increasing evidence that adenocarcinoma is also induced." [4][5][6][7] The second factor is the exposure to radiation. Patients with ankylosing spondylitis have a higher mortality than the general population.18 19 However, the patterns of mortality change with radiation exposure.…”

L'atteinte pleuropulmonaire de la spondylarthrite ankylosante

“…La FA est donc plus fréquente que la tuberculose dans la SPA. Wolson [24], en 1975, retrouve parmi 52 malades atteints de SPA, deux cas de FA. À la Mayo Clinic, Rosenow et al [25] revoient 2080 radiographies thoraciques de SPA, 26 cas de FA (1,2 %) sont observés.…”