Upper cerebellar glucose hypermetabolism in patients with temporal lobe epilepsy and interictal psychosis

Sone, Daichi; Shigemoto, Yoko; Kimura, Yukio

doi:10.1002/epi4.12645

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) is also widely used in clinical practice in cases of epilepsy ( 47 ), but FDG-PET studies on psychosis in epilepsy are more limited compared with perfusion SPECT studies. A recent study found brain glucose hypermetabolism in the upper cerebellum, superior cerebellar peduncle, and midbrain ( 48 ) ( Figure 1D ), which might be associated with cerebellar involvement in cognition and emotion ( 49 , 50 ). Thus, most functional neuroimaging studies have suggested brain hyperactivity in psychosis in epilepsy, while the reported abnormal areas are diverse.…”

Section: Functional Neuroimaging Of Psychosis In Epilepsymentioning

confidence: 90%

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Neurobiological mechanisms of psychosis in epilepsy: Findings from neuroimaging studies

Sone

2022

Front. Psychiatry

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Despite the high prevalence and clinical importance of comorbid psychosis in epilepsy, its neurobiological mechanisms remain understudied. This narrative mini-review aims to provide an overview of recent updates in in vivo neuroimaging studies on psychosis in epilepsy, including structural and diffusion magnetic resonance imaging (MRI) and functional and molecular imaging, and to discuss future directions in this field. While the conventional morphological analysis of structural MRI has provided relatively inconsistent results, advanced methods, including brain network analysis, hippocampal subregion volumetry, and machine learning models, have recently provided novel findings. Diffusion MRI, for example, has revealed a reduction in white matter integrity mainly in the frontal and temporal lobes, as well as a disruption of brain white matter networks. Functional neuroimaging, such as perfusion single-photon emission computed tomography (SPECT) or fluorodeoxyglucose positron emission tomography (FDG-PET), often identifies hyperactivity in various brain regions. The current limitations of these more recent studies may include small and sometimes heterogeneous samples, insufficient control groups, the effects of psychoactive drugs, and the lack of longitudinal analysis. Further investigations are required to establish novel treatments and identify clinical diagnostic or disease-monitoring biomarkers in psychosis in epilepsy.

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Section: Functional Neuroimaging Of Psychosis In Epilepsymentioning

confidence: 90%

“…(C) Disrupted brain white matter networks in TLE-P and TLE-NonP, derived from diffusion MRI [Cited from Sone et al ( 40 )]. (D) Hypermetabolic areas in TLE-P compared to TLE-NonP, derived from fluorodeoxyglucose positron emission tomography (FDG-PET) [Cited from Sone et al ( 48 )].…”

Section: Structural Magnetic Resonance Imaging Of Psychosis In Epilepsymentioning

confidence: 99%

Neurobiological mechanisms of psychosis in epilepsy: Findings from neuroimaging studies

Sone

2022

Front. Psychiatry

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Upper cerebellar glucose hypermetabolism in patients with temporal lobe epilepsy and interictal psychosis

2022

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White matter brain-age in diverse forms of epilepsy and interictal psychosis

Sone,

Beheshti,

Shigemoto

et al. 2024

Sci Rep

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Abnormal brain aging is suggested in epilepsy. Given the brain network dysfunction in epilepsy, the white matter tracts, which primarily interconnect brain regions, could be of special importance. We focused on white matter brain aging in diverse forms of epilepsy and comorbid psychosis. We obtained brain diffusion tensor imaging (DTI) data at 3 T-MRI in 257 patients with epilepsy and 429 healthy subjects. The tract-based fractional anisotropy values of the healthy subjects were used to build a brain-age prediction model, and we calculated the brain-predicted age difference (brain-PAD: predicted age—chronological age) of all subjects. As a result, almost all epilepsy categories showed significantly increased brain-PAD (p < 0.001), including temporal lobe epilepsy (TLE) with no MRI-lesion (+ 4.2 yr), TLE with hippocampal sclerosis (+ 9.1 yr), extratemporal focal epilepsy (+ 5.1 yr), epileptic encephalopathy or progressive myoclonus epilepsy (+ 18.4 yr), except for idiopathic generalized epilepsy (IGE). Patients with psychogenic non-epileptic seizures also presented increased brain-PAD. In TLE, interictal psychosis significantly raised brain-PAD by 8.7 years. In conclusion, we observed increased brain aging in most types of epilepsy, which was generally consistent with brain morphological aging results in previous studies. Psychosis may accelerate brain aging in TLE. These findings may suggest abnormal aging mechanisms in epilepsy and comorbid psychotic symptoms.

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Upper cerebellar glucose hypermetabolism in patients with temporal lobe epilepsy and interictal psychosis

Cited by 3 publications

References 40 publications

Neurobiological mechanisms of psychosis in epilepsy: Findings from neuroimaging studies

Neurobiological mechanisms of psychosis in epilepsy: Findings from neuroimaging studies

Upper cerebellar glucose hypermetabolism in patients with temporal lobe epilepsy and interictal psychosis

White matter brain-age in diverse forms of epilepsy and interictal psychosis

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