A mixed dominating set of a graph G = (V, E) is a mixed set D of vertices and edges, such that for every edge or vertex, if it is not in D, then it is adjacent or incident to at least one vertex or edge in D. The mixed domination problem is to find a mixed dominating set with a minimum cardinality. It has applications in system control and some other scenarios and it is N P -hard to compute an optimal solution. This paper studies approximation algorithms and hardness of the weighted mixed dominating set problem. The weighted version is a generalization of the unweighted version, where all vertices are assigned the same nonnegative weight w v and all edges are assigned the same nonnegative weight w e , and the question is to find a mixed dominating set with a minimum total weight. Although the mixed dominating set problem has a simple 2-approximation algorithm, few approximation results for the weighted version are known. The main contributions of this paper include:1. for w e ≥ w v , a 2-approximation algorithm; 2. for w e ≥ 2w v , inapproximability within ratio 1.3606 unless P = N P and within ratio 2 under UGC; 3. for 2w v > w e ≥ w v , inapproximability within ratio 1.1803 unless P = N P and within ratio 1.5 under UGC; 4. for w e < w v , inapproximability within ratio (1 − ) ln |V | unless P = N P for any > 0.