UPLC-MS-ESI-QTOF analysis and Anti-Candida activity of fractions from Psidium guajava L.

Bezerra, Camila Fonseca; Rocha, Janaína Esmeraldo; Silva, Maria Karollyna do Nascimento; Freitas, Thiago Sampaio de; Sousa, Amanda Karine de; Carneiro, Joara Nályda Pereira; Leal, Antônio Linkoln Alves Borges; Santos, Antônia Thassya Lucas dos; Cruz, Rafael Pereira da; Rodrigues, Anderson da Silva; Sales, Débora Lima; Coutinho, Henrique Douglas Melo; Ribeiro, Paulo Riceli Vasconcelos; Brito, Edy Sousa de; Costa, José Galberto Martins da; Menezes, Irwin Rose Alencar de; Almeida, Waltécio de Oliveira; Morais-Braga, Maria Flaviana Bezerra

doi:10.1016/j.sajb.2020.03.020

Cited by 4 publications

(4 citation statements)

References 27 publications

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“…Triagens fitoquímicas de folhas de P. guajava, por meio de extratos a partir de diferentes solventes, tais como: água, etanol, clorofórmio, éter de petróleo e hexano, mostraram a presença de alcaloides, carboidratos, taninos, terpenoides, flavonoides, fenois, entre outras substâncias (56,68,(145)(146)(147)(148)(149)(150)(151)(152)(153)(154)(155)(156). Um compilado dos principais compostos identificados pode ser visualizado no Quadro 3.…”

Section: Droga Vegetal (Folhas)unclassified

Etnofarmacologia, Fitoquímica, Toxicologia E Atividades Anti-Inflamatória E Antinociceptiva De Folhas De Psidium Guajava L.: Uma Revisão

Almeida,

Martins,

Souza

et al. 2023

Infarma

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Psidium guajavaL. (Myrtaceae), conhecida como goiabeira, é uma importante espécie vegetal com diversos valores medicinais. Na medicina tradicional, é utilizada para o tratamento de uma série de doenças, como distúrbios gastrointestinais, processos inflamatórios, no tratamento de cáries, em afecções dermatomucosas, como analgésico, em distúrbios respiratórios, dentre outros. As ações podem ser atribuídas à infinidade de compostos bioativos presentes em P. guajava. O objetivo desta revisão é fornecer informações atualizadas sobre os usos etnomedicinais, compostos bioativos, potenciais ações anti-inflamatória e antinociceptiva, além da toxicidade das folhas de P. guajava L. A estratégia de busca utilizada continha o nome científico, sinonímias e nomes populares da espécie vegetal. As bases de dados consultadas foram Cochrane, Medline, SCOPUS, Science Direct, Web of Science, Lilacs, SciELO, Google acadêmico e Google books.; além de monografias em compêndios oficiais. Dentre os principais fitoquímicos extraídos de folhas de P. guajava, podem ser citados compostos dos grupos dos flavonoides, taninos, terpenoides, saponinas e óleos essenciais. Estudos in vitro e in vivo sugerem que derivados das folhas da espécie vegetal possuem potencial anti-inflamatório e antinociceptivo. Assim, considerando seu perfil fitoquímico e seus efeitos benéficos, derivados das folhas da espécie podem, potencialmente, serem utilizados no desenvolvimento de produtos farmacêuticos. Contudo, lacunas consideráveis ainda precisam ser preenchidas, como por exemplo, aquelas relacionadas a padronização do método extrativo e no que diz respeito a relação droga:derivado obtida. Ademais, há necessidade de ensaios clínicos mais robustos para estabelecer as doses seguras e a eficácia de P. guajava como agente anti-inflamatório.

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Section: Droga Vegetal (Folhas)unclassified

Etnofarmacologia, Fitoquímica, Toxicologia E Atividades Anti-Inflamatória E Antinociceptiva De Folhas De Psidium Guajava L.: Uma Revisão

Almeida,

Martins,

Souza

et al. 2023

Infarma

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“…The literature revealed that UPLC-ESI-QTOF-MS analysis of the leaves extract of P. guajava disclosed fourteen compounds ( Table 2 ) of phenolic class of secondary metabolites [ 21 ], while in another report, the chemical profiling by HPLC-PDA and LC-TOF-MS (negative and positive modes) showed the presence of altogether 21 compounds ( Table 2 ) from seven P. guajava cultivars [ 22 ]. Study on pink guava ( P. guajava L.), the phytochemical investigation through ultra-high performance liquid chromatography with diode array result in identification of 60 phenolics with different structural features, such as flavonoids, ellagitannins, flavones, flavonols, flavanols, proanthocyanidins, dihydrochalcones and anthocyanidins, stilbenes, acetophenones, and benzophenones.…”

Section: Phytochemistry Of P Guajava Lmentioning

confidence: 99%

“…The P. guajava leaves extract was used for microbiological assays to determine IC 50 , inhibitory effect of associated fraction with Fluconazole against Candida species and cell viability curve through microdilution method. Antifungal bioassay performed on solid media by modifying morphological and fungicidal concentration and results ranged between 5.10 and 926.56 mg/mL revealed the effect of change in concentration effects the inhibition [ 21 ]. This suggests that P. brownianum and P. guajava can potentially be used to develop drugs to treat fungal infections [ 63 , 64 ].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

“…The upward requirement for biologic-based enzymes, in the food and pharmaceutical industries, has made them an interesting topic for physiologists and biochemists. The existence of two pH optima of P. guajava leaves protease suggests that at least two major proteases are present in it [ 21 ]. An environmentally friendly and cost-effective material CuONPs was biosynthesized by using P. guajava L. leaf.…”

Section: Industrial Applications Of P Guajavamentioning

confidence: 99%

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Psidium guajava L. An Incalculable but Underexplored Food Crop: Its Phytochemistry, Ethnopharmacology, and Industrial Applications

et al. 2022

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Psidium guajava L. (guava) is a small tree known for its fruit flavor that is cultivated almost around the globe in tropical areas. Its fruit is amazingly rich in antioxidants, vitamin C, potassium, and dietary fiber. In different parts of the world, this plant holds a special place with respect to fruit and nutritional items. Pharmacological research has shown that this plant has more potential than just a fruit source; it also has beneficial effects against a variety of chronic diseases due to its rich nutritional and phytochemical profile. The primary goal of this document is to provide an updated overview of Psidium guajava L. and its bioactive secondary metabolites, as well as their availability for further study, with a focus on the health benefits and potential industrial applications. There have been several studies conducted on Psidium guajava L. in relation to its use in the pharmaceutical industry. However, its clinical efficacy and applications are still debatable. Therefore, in this review a detailed study with respect to phytochemistry of the plant through modern instruments such as GC and LC-MS has been discussed. The biological activities of secondary metabolites isolated from this plant have been extensively discussed. In order to perform long-term clinical trials to learn more about their effectiveness as drugs and applications for various health benefits, a structure activity relationship has been established. Based on the literature, it is concluded that this plant has a wide variety of biopharmaceutical applications. As a whole, this article calls for long-term clinical trials to obtain a greater understanding of how it can be used to treat different diseases.

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The ethnobotanical, phytochemistry and pharmacological activities of Psidium guajava L.

Ugbogu

Emmanuel

Uche

et al. 2022

Arabian Journal of Chemistry

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UPLC-MS-ESI-QTOF analysis and Anti-Candida activity of fractions from Psidium guajava L.

Cited by 4 publications

References 27 publications

Etnofarmacologia, Fitoquímica, Toxicologia E Atividades Anti-Inflamatória E Antinociceptiva De Folhas De Psidium Guajava L.: Uma Revisão

Etnofarmacologia, Fitoquímica, Toxicologia E Atividades Anti-Inflamatória E Antinociceptiva De Folhas De Psidium Guajava L.: Uma Revisão

Psidium guajava L. An Incalculable but Underexplored Food Crop: Its Phytochemistry, Ethnopharmacology, and Industrial Applications

The ethnobotanical, phytochemistry and pharmacological activities of Psidium guajava L.

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