Updating a 12-year experience with arrest and reversal therapy for coronary heart disease (an overdue requiem for palliative cardiology)

Esselstyn, Caldwell B.

doi:10.1016/s0002-9149(99)00290-8

Cited by 88 publications

(66 citation statements)

References 17 publications

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“…At 5 years there also was a 60% decrease in relative risk in cardiac events in the intervention group. Likewise, Esselstyn and colleagues 115,116 reported disease arrest (measured by angiographic analysis) in all patients (n 5 11) with severe CAD who followed a plant-based diet containing less than 10% fat after 5 years. In addition, the investigators reported regression in 8 (73%) adherent patients and no extension of clinical disease or coronary events after 12 years.…”

Section: Lifestyle Approaches and Dietary Strategiesmentioning

confidence: 98%

Lifestyle Approaches and Dietary Strategies to Lower LDL-Cholesterol and Triglycerides and Raise HDL-Cholesterol

Katcher

Hill

Lanford

et al. 2009

Endocrinology and Metabolism Clinics of North America

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Section: Lifestyle Approaches and Dietary Strategiesmentioning

confidence: 98%

Lifestyle Approaches and Dietary Strategies to Lower LDL-Cholesterol and Triglycerides and Raise HDL-Cholesterol

Katcher

Hill

Lanford

et al. 2009

Endocrinology and Metabolism Clinics of North America

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“…[70][71][72] Getting patients to abstain from all animal products is a difficult enough proposition, and the additional proscription of added oils makes it all the harder as fat has a major impact on flavour. The possibility that laurate-rich MCTs might be used safely with such regimens is worthy of consideration.…”

Section: Using Laurate-rich Mcts: Practical Considerationsmentioning

confidence: 99%

Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity

McCarty

DiNicolantonio

2016

Open Heart

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Recently, medium-chain triglycerides (MCTs) containing a large fraction of lauric acid (LA) (C12)—about 30%—have been introduced commercially for use in salad oils and in cooking applications. As compared to the long-chain fatty acids found in other cooking oils, the medium-chain fats in MCTs are far less likely to be stored in adipose tissue, do not give rise to ‘ectopic fat’ metabolites that promote insulin resistance and inflammation, and may be less likely to activate macrophages. When ingested, medium-chain fatty acids are rapidly oxidised in hepatic mitochondria; the resulting glut of acetyl-coenzyme A drives ketone body production and also provokes a thermogenic response. Hence, studies in animals and humans indicate that MCT ingestion is less obesogenic than comparable intakes of longer chain oils. Although LA tends to raise serum cholesterol, it has a more substantial impact on high density lipoprotein (HDL) than low density lipoprotein (LDL) in this regard, such that the ratio of total cholesterol to HDL cholesterol decreases. LA constitutes about 50% of the fatty acid content of coconut oil; south Asian and Oceanic societies which use coconut oil as their primary source of dietary fat tend to be at low cardiovascular risk. Since ketone bodies can exert neuroprotective effects, the moderate ketosis induced by regular MCT ingestion may have neuroprotective potential. As compared to traditional MCTs featuring C6–C10, laurate-rich MCTs are more feasible for use in moderate-temperature frying and tend to produce a lower but more sustained pattern of blood ketone elevation owing to the more gradual hepatic oxidation of ingested laurate.

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“…Ferdowsian and Barnard [25] recently published a review of studies of vegetarian and vegan diets, which concluded that a plant-based diet combined with nuts, soy, and/or soluble fiber can reduce LDL cholesterol by 25% to 30%, a figure comparable to what can be achieved with statin drugs [26]. Esselstyn [27] demonstrated reversal of heart disease in a 12-year study of 17 participants with severe coronary artery disease, with a diet that included no meat, animal products, or added fats. Ornish et al [28] effectively used a low-fat (10%), plant-based dietary approach in a 5-year landmark MLDP (Multicenter Lifestyle Demonstration Project) clinical trial demonstrating reversal of heart disease.…”

Section: Cardiovascular Diseasementioning

confidence: 99%

Usefulness of Vegetarian and Vegan Diets for Treating Type 2 Diabetes

Trapp

Barnard

2010

Curr Diab Rep

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Significant benefits for diabetes prevention and management have been observed with vegetarian and especially vegan diets. This article reviews observational studies and intervention trials on such diets, and discusses their efficacy, nutritional adequacy, acceptability, and sustainability. Research to date has demonstrated that a low-fat, plant-based nutritional approach improves control of weight, glycemia, and cardiovascular risk. These studies have also shown that carefully planned vegan diets can be more nutritious than diets based on more conventional diet guidelines, with an acceptability that is comparable with that of other therapeutic regimens. Current intervention guidelines from professional organizations offer support for this approach. Vegetarian and vegan diets present potential advantages in managing type 2 diabetes that merit the attention of individuals with diabetes and their caregivers.

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Updating a 12-year experience with arrest and reversal therapy for coronary heart disease (an overdue requiem for palliative cardiology)

Cited by 88 publications

References 17 publications

Lifestyle Approaches and Dietary Strategies to Lower LDL-Cholesterol and Triglycerides and Raise HDL-Cholesterol

Lifestyle Approaches and Dietary Strategies to Lower LDL-Cholesterol and Triglycerides and Raise HDL-Cholesterol

Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity

Usefulness of Vegetarian and Vegan Diets for Treating Type 2 Diabetes

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