Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity

McCarty, Mark F.; DiNicolantonio, James J.

doi:10.1136/openhrt-2016-000467

Cited by 74 publications

(52 citation statements)

References 65 publications

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“…and the current findings. When ingested, MCFA are able to pass directly from the intestine to the liver via the portal vein, where they are rapidly oxidized to acetyl‐coenzyme and thus driving ketone body production (Kinderlerer, ; McCarty & DiNicolantonio, ) . Lipid hydrolysis increased peroxisome proliferator‐activated receptors‐α transcription, which plays an important role in hepatic lipid catabolism by inducing the expression of genes involved in the mitochondrial and peroxisomal fatty acid oxidation (Henderson & Sargent, ).…”

Section: Discussionmentioning

confidence: 99%

Insect-based diets high in lauric acid reduce liver lipids in freshwater Atlantic salmon

et al. 2018

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We evaluated the effect of a diet containing insect meal and insect oil on nutrient utilization, tissue fatty acid profile and lipid metabolism of freshwater Atlantic salmon (Salmo salar). Insect meal and insect oil from black soldier fly larvae (Hermetia illucens, L.; BSF), naturally high in lauric acid (12:0), were used to produce five experimental diets for an eight-week feeding trial. 85% of the dietary protein was replaced by insect meal and/or all the vegetable oil was replaced by one of two types of insect oil.A typical industrial diet, with protein from fishmeal and soy protein concentrate (50:50) and lipids from fish oil and vegetable oil (33:66), was fed to a control group.The dietary BSF larvae did not modify feed intake or whole body lipid content.Despite the high content of saturated fatty acids in the insect-based diets, the apparent digestibility coefficients of all fatty acids were high. There was a decrease in liver triacylglycerols of salmon fed the insect-based diets compared to the fish fed the control diet. This is likely due to the rapid oxidation and low deposition of the medium-chain fatty acid lauric acid. K E Y W O R D SAtlantic salmon, black soldier fly, fatty acid oxidation, lauric acid, lipid metabolism, mediumchain FA S U PP O RTI N G I N FO R M ATI O NAdditional supporting information may be found online in the Supporting Information section at the end of the article. How to cite this article: Belghit I, Waagbø R, Lock E-J, Liland NS. Insect-based diets high in lauric acid reduce liver lipids in freshwater Atlantic salmon. Aquacult Nutr. 2019;25:343-357.

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Section: Discussionmentioning

confidence: 99%

Insect-based diets high in lauric acid reduce liver lipids in freshwater Atlantic salmon

et al. 2018

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“…Indeed, saturated FAs increase serum cholesterol levels, risk of coronary heart disease, diabetes, and impaired memory . Coconut oil also contains high amounts of saturated FAs, but these differ from animal FAs because they include large amounts of medium‐chain FAs (MCFAs) . MCFAs are considered healthy because they are easily digestible by direct transportation to the liver via the portal vein and oxidation to ketones.…”

Section: Introductionmentioning

confidence: 99%

Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice

Tiwari

Nagatake

Hirata

et al. 2019

Allergy

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Coconut oil is used as a dietary oil worldwide, and its healthy effects are recognized by the fact that coconut oil is easy to digest, helps in weight management, increases healthy cholesterol, and provides instant energy. Although topical application of coconut oil is known to reduce skin infection and inflammation, whether dietary coconut oil has any role in decreasing skin inflammation is unknown. In this study, we showed the impact of dietary coconut oil in allergic skin inflammation by using a mouse model of contact hypersensitivity (CHS). Mice maintained on coconut oil showed amelioration of skin inflammation and increased levels of cis-5, 8, 11-eicosatrienoic acid (mead acid) in serum. Intraperitoneal injection of mead acid inhibited CHS and reduced the number of neutrophils infiltrating to the skin. Detailed mechanistic studies unveiled that mead acid inhibited the directional migration of neutrophils by inhibiting the filamentous actin polymerization and leukotriene B 4 production required for secondary recruitment of neutrophils. Our findings provide valuable insights into the preventive roles of coconut oil and mead acid against skin inflammation, thereby offering attractive therapeutic possibilities. K E Y W O R D S coconut oil, LTB 4 , mead acid, neutrophils, skin inflammation | 1523 TIWARI eT Al.

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“…Medium-chain fatty acids are also less efficiently stored in the body than other fatty acids and are highly prone to oxidative metabolism once ingested, implying that they are unlikely to contribute to obesity via direct storage in adipocytes, and may be useful in dietary regimens. 35 In this study, synthetic MGD significantly suppressed wide-spectrum organ metastasis, including that to the lymph nodes and lungs.…”

Section: Effects Of Akt Phosphorylation By A-mangostin Dilauratementioning

confidence: 57%

Synthetic α‐mangostin dilaurate strongly suppresses wide‐spectrum organ metastasis in a mouse model of mammary cancer

et al. 2018

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We previously reported that, in a mouse model of mammary cancer, α‐mangostin alone exhibits anti‐metastatic properties. To enhance this anti‐metastatic effect, we examined the efficacy of synthetic α‐mangostin dilaurate (MGD), prepared by adding lauric acid to α‐mangostin, in the same experimental system wherein mice bearing mammary tumors are exposed to dietary MGD at 0, 2000 and 4000 ppm. Lauric acid has a high propensity for lymphatic absorption, which is the most common pathway of initial dissemination of many solid malignancies. Both mammary tumor volumes and wide‐spectrum organ metastasis were markedly reduced at 2000 and 4000 ppm: furthermore, survival in the 4000‐ppm group was significantly greater than in control mice. Apoptosis in mammary carcinomas was also significantly increased in the 4000‐ppm group, whereas blood microvessel density and lymphatic vessel invasion were markedly reduced. In real‐time PCR analyses of tumor samples, increased p21 and decreased Pcna expression were observed with 4000 ppm but values were not statistically significant when compared to expression in control tumors. However, exposure to 4000 ppm significantly decreased expression of phospho‐Akt (Ser473/Thr308) as compared to the control, indicating a role in the anti‐tumorigenic effects of MGD. These findings suggest that MGD may be useful for adjuvant therapy and chemoprevention and that conjugated medium‐chain fatty acids may enhance the efficacy of certain chemotherapeutic agents.

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Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity

Cited by 74 publications

References 65 publications

Insect-based diets high in lauric acid reduce liver lipids in freshwater Atlantic salmon

Insect-based diets high in lauric acid reduce liver lipids in freshwater Atlantic salmon

Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice

Synthetic α‐mangostin dilaurate strongly suppresses wide‐spectrum organ metastasis in a mouse model of mammary cancer

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