Updates on thermosensitive hydrogel for nasal, ocular and cutaneous delivery

Wang, Qianwen; Zuo, Zhong; Cheung, Cheuk Kit Chucky; Leung, Sharon Shui Yee

doi:10.1016/j.ijpharm.2019.01.030

Cited by 58 publications

(33 citation statements)

References 106 publications

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“…The active substances reach the brain directly from the nasal cavity, along the trigeminal nerve and through the olfactory system, bypassing the BBB in a non-invasive way [ 9 , 103 ], or are absorbed through the nasal epithelium into the systemic circulation and then pass by the BBB in the central nervous system (CNS) [ 104 ]. Systems that deliver the drug without being invasive and without penetrating BBB are considered to be third-generation systems [ 11 ].…”

Section: The Nasal Routementioning

confidence: 99%

“…This route can be used for any age category, but especially in children and the elderly or unconscious people [ 3 , 4 , 103 ], without the need for qualified staff [ 9 , 61 ]. Nasal administration has other advantages: It is not painful [ 60 ], it does not require sterilization [ 9 ], it is non-invasive [ 61 ], parenteral administration can be avoided (e.g., for insulin) [ 3 , 4 , 103 ], and it increases the patient’s adhesion to treatment [ 9 ]. Enzymatic and acidic degradation in the gastrointestinal tract is prevented by the nasal administration of drugs (e.g., insulin) [ 106 ] and the effect of systemic dilution is minimized [ 104 ].…”

Section: The Nasal Routementioning

confidence: 99%

“…The development of thermo-sensitive hydrogels, which are administered in the nasal route and which pass from the soil phase at room temperature to the gel phase when they reach body temperature is constantly advancing [ 3 , 103 , 116 ]. A hydrogel based on chitosan and β-glycerophosphate is a thermo-sensitive one [ 3 , 118 ].…”

Section: Chitosan-based Formulations For Intranasal Administrationmentioning

confidence: 99%

See 2 more Smart Citations

New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

Popescu

Ghica

Dinu-Pîrvu

et al. 2020

IJMS

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In an attempt to develop drug delivery systems that bypass the blood–brain barrier (BBB) and prevent liver and intestinal degradation, it was concluded that nasal medication meets these criteria and can be used for drugs that have these drawbacks. The aim of this review is to present the influence of the properties of chitosan and its derivatives (mucoadhesion, permeability enhancement, surface tension, and zeta potential) on the development of suitable nasal drug delivery systems and on the nasal bioavailability of various active pharmaceutical ingredients. Interactions between chitosan and proteins, lipids, antigens, and other molecules lead to complexes that have their own applications or to changing characteristics of the substances involved in the bond (conformational changes, increased stability or solubility, etc.). Chitosan and its derivatives have their own actions (antibacterial, antifungal, immunostimulant, antioxidant, etc.) and can be used as such or in combination with other molecules from the same class to achieve a synergistic effect. The applicability of the properties is set out in the second part of the paper, where nasal formulations based on chitosan are described (vaccines, hydrogels, nanoparticles, nanostructured lipid carriers (NLC), powders, emulsions, etc.).

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Section: The Nasal Routementioning

confidence: 99%

Section: The Nasal Routementioning

confidence: 99%

Section: Chitosan-based Formulations For Intranasal Administrationmentioning

confidence: 99%

See 1 more Smart Citation

New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

Popescu

Ghica

Dinu-Pîrvu

et al. 2020

IJMS

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“…The polymeters P407 and P188 are the most popular thermosensitive gelling agents used for the topical applications through the nasal, ocular and cutaneous routes and also have lower adverse effect on tissues compared with other stimuli-responsive gelling systems (20). Furthermore, 0.05 % ethylparaben is often used in oral and ophthalmic preparations and HP-β-CD used as additive in the intravenous injections.…”

Section: Preparation Of In Situ Gelmentioning

confidence: 99%

Preparation, characterization, and in vivo pharmacokinetics of thermosensitive in situ nasal gel of donepezil hydrochloride

Fan

Cong

et al. 2020

Acta Pharmaceutica

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Donepezil hydrochloride thermosensitive in situ gel for nasal delivery was prepared by using Poloxamer 407 and Poloxamer 188 as thermoreversible polymers, hydroxypropyl-β-cyclodextrin and ethylparaben as permeation enhancer and preservative, respectively. The gelation temperature and time, pH value of the gel formulation were found to meet the requirements for nasal administration. The in vitro erosion and in vitro release tests exhibited obvious drug sustained release behavior. Meantime, main pharmacokinetic parameters such as tmax, cmax and AUC in plasma as well as in brain were significantly different between the nasal gel formulation and intragastric drug solution in rats (p < 0.01). The relative bioavailability and drug targeting efficiency of the gel formulation were calculated to be 385.6 and 151.2 %, respectively. Thus, the drug gel formulation might be a potential new delivery system for treatment of Alzheimer’s disease due to its higher bioavailability and better distribution to brain when compared to oral route.

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“…Another interesting approach to ocular drug delivery is the use of hydrogel systems. Among hydrogels the most interesting for the ocular administration of drugs are the thermosensitive hydrogels that can be instilled in the form of drops and become gels once in contact with the eyes [6][7][8]. In particular, chitosan-based thermosensitive hydrogels have proved to be vehicles of choice for biomedical application because they possess mucoadhesive, antibacterial, biodegradable, and biocompatible properties [7,9].…”

Section: Introductionmentioning

confidence: 99%

Impact of Different Mucoadhesive Polymeric Nanoparticles Loaded in Thermosensitive Hydrogels on Transcorneal Administration of 5-Fluorouracil

et al. 2019

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In a previous paper a thermosensitive hydrogel formulation based on chitosan or its derivatives (TSOH), containing medicated chitosan nanoparticles (Ch NP) for transcorneal administration of 5-fluorouracil (5-FU) was described. The Ch NP-containing TSOH allowed a time-constant 5-FU concentration in the aqueous for 7 h from instillation. The aim of the present work was to study the impact of the surface characteristics of new NP contained in TSOH on ocular 5-FU bioavailability. The Ch derivatives used to prepare NP were quaternary ammonium-Ch conjugate (QA-Ch), S-protected derivative thereof (QA-Ch-S-pro), and a sulphobutyl chitosan derivative (SB-Ch). All NP types had 300–400 nm size, 16–18% encapsulation efficiency, and retained the entrapped drug for at least 15 h. Drug release from TSOH containing NP based on QA-Ch or QA-Ch-S-pro was virtually equal, whereas with TSOH containing NP based on SB-Ch was significantly slower. Instillation, in rabbit eyes, of NP-containing TSOH based on QA-Ch or SB-Ch led to a plateau in the aqueous concentration vs. time plot in the 1–10 h range with significantly enhanced area under curve (AUC). Negative charges on the NP surface slowed down 5-FU release from TSOH while positive charges increased NP contact with the negatively charged ocular surface. Either results in enhanced ocular bioavailability.

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Updates on thermosensitive hydrogel for nasal, ocular and cutaneous delivery

Cited by 58 publications

References 106 publications

New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

Preparation, characterization, and in vivo pharmacokinetics of thermosensitive in situ nasal gel of donepezil hydrochloride

Impact of Different Mucoadhesive Polymeric Nanoparticles Loaded in Thermosensitive Hydrogels on Transcorneal Administration of 5-Fluorouracil

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