Updates on the versatile quinoline heterocycles as anticancer agents

Abstract

Quinoline motifs have befallen significant molecules due to their assortment of interest in medicine, chemical synthesis, coordination chemistry, also in the field of applied chemistry. Therefore, various researchers have produced these molecules as objective structures and studied their natal potential. The current chapter endows with concise attention about cancer, anticancer agents, sources (natural) of quinoline, and together with an innovative scope of quinoline-related medicines. Further, the present section gives knowledge concerned with the anticancer activity of synthesized quinolines and their derivatives.

Investigation of embelin synthetic hybrids as potential COVID-19 and COX inhibitors: Synthesis, spectral analysis, DFT calculations and molecular docking studies

“…Their result suggests that these compounds exhibited significant X-linked inhibitors of apoptosis protein (which plays a critical role in cell death and inflammation) inhibition and apoptosis in various cancer cell lines, which is probably independent of inhibition [ 11 , 12 ]. In view of these findings and with the continuation of our research work on biologically active molecules [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , we herein were reporting the synthesis of embelin synthetic hybrids as cyclooxygenase inhibitors and molecular docking studies with SARS-CoV-2 omicron protease & cyclooxygenase enzyme. Initially, embelin was isolated from Embelia ribes fruit by our early reported method.…”