Updates in Clinical and Translational Glaucoma Research

García-Medina, Manuel; Pinazo-Durán, María Dolores

doi:10.3390/jcm11010221

Cited by 2 publications

(2 citation statements)

References 30 publications

(29 reference statements)

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“…Changes leading to a reduced density and calibre of retinal blood vessels occur during glaucoma [1,[6][7][8]. Numerous studies using optical coherence tomography angiography (OCTA) have shown significant reductions in the flow density, flow index, and vessel density in the optic nerve head and macula in patients with glaucoma compared to controls, as well as the association between these parameters and changes in the visual field [6,[9][10][11][12]. Colour Doppler Imaging has demonstrated reduced velocities and an increased resistivity index in intraocular vessels in glaucoma patients [13].…”

Section: Introductionmentioning

confidence: 99%

Is Primary Open-Angle Glaucoma a Vascular Disease? Assessment of the Relationship between Retinal Arteriolar Morphology and Glaucoma Severity Using Adaptive Optics

Szewczuk,

Wawrzyniak,

Szaflik

et al. 2024

JCM

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Background: Retinal vascular abnormalities may be associated with glaucomatous damage. Adaptive optics (AO) is a new technology that enables the analysis of retinal vasculature at the cellular level in vivo. The purpose of this study was to evaluate retinal arteriolar parameters using the rtx1 adaptive optics fundus camera (AO-FC) in patients with primary open-angle glaucoma (POAG) at different stages and to investigate the relationship between these parameters and changes in spectral-domain optical coherence tomography (SD-OCT) and perimetry. Methods: Parameters of the retinal supratemporal and infratemporal arterioles (wall thickness (WT), lumen diameter (LD), total diameter (TD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall (WCSA)) were analysed with the rtx1 in 111 POAG eyes, which were divided into three groups according to the severity of the disease, and 70 healthy eyes. The associations between RTX1 values and the cup-to-disk ratio, SD-OCT parameters, and visual field parameters were assessed. Results: Compared with the control group, the POAG groups showed significantly smaller TD and LD values (p < 0.05) and significantly higher WLR and WT values (p < 0.05) for the supratemporal and infratemporal arterioles. TD was significantly positively correlated with the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) (p < 0.05). LD was significantly positively correlated with the RNFL, GCC, and rim area (p < 0.05). The WLR was significantly negatively correlated with the RNFL, GCC, rim area, and MD (p < 0.05), while it was significantly positively correlated with the cup-to-disc ratio and PSD (p < 0.05). Conclusions: The results suggest that vascular dysfunction is present in POAG, even at a very early stage of glaucoma, and increases with the severity of the disease.

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Section: Introductionmentioning

confidence: 99%

Is Primary Open-Angle Glaucoma a Vascular Disease? Assessment of the Relationship between Retinal Arteriolar Morphology and Glaucoma Severity Using Adaptive Optics

Szewczuk,

Wawrzyniak,

Szaflik

et al. 2024

JCM

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show abstract

“…It is defined by the optic nerves' specific appearance and visual field disturbances. Glaucoma is the second leading cause of blindness and the leading cause of irreversible blindness worldwide [ 1 , 2 ]. Although various factors are associated with the pathogenesis of this disease, the exact mechanism needs to be further understood and studied.…”

Section: Introductionmentioning

confidence: 99%

Comparing corneal biomechanics and intraocular pressure between healthy individuals and glaucoma subtypes: A cross-sectional study

Zarei

Zamani

Eslami

et al. 2022

Annals of Medicine &Amp; Surgery

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Updates in Clinical and Translational Glaucoma Research

Abstract: Glaucoma is a sight-threatening disease and the primum mobile of irreversible blindness worldwide [...]

Cited by 2 publications

References 30 publications

Is Primary Open-Angle Glaucoma a Vascular Disease? Assessment of the Relationship between Retinal Arteriolar Morphology and Glaucoma Severity Using Adaptive Optics

Is Primary Open-Angle Glaucoma a Vascular Disease? Assessment of the Relationship between Retinal Arteriolar Morphology and Glaucoma Severity Using Adaptive Optics

Comparing corneal biomechanics and intraocular pressure between healthy individuals and glaucoma subtypes: A cross-sectional study

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