Comparing corneal biomechanics and intraocular pressure between healthy individuals and glaucoma subtypes: A cross-sectional study

Zarei, EReza; Zamani, Mehdi; Eslami, Yadollah; Fakhraei, GHasem; Tabatabaei, S A; Esfandiari, Amir Reza

doi:10.1016/j.amsu.2022.104677

Cited by 3 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High-tension glaucoma (HTG) and normal tension glaucoma (NTG) are subtypes of primary open angle glaucoma (POAG), displaying the same ocular deterioration but different untreated intraocular pressure (IOP). Previous studies claimed that NTG had significantly lower CH and CRF than HTG,8–10 and others argued that NTG patients had more deformable corneas than HTG patients 11–13. Otherwise, several studies have suggested that patients with ocular hypertension (OHT) but no glaucomatous changes showed less deformable corneas 9,10,14–16.…”

mentioning

confidence: 99%

“…Previous studies claimed that NTG had significantly lower CH and CRF than HTG, [8][9][10] and others argued that NTG patients had more deformable corneas than HTG patients. [11][12][13] Otherwise, several studies have suggested that patients with ocular hypertension (OHT) but no glaucomatous changes showed less deformable corneas. 9,10,[14][15][16] These corneal biomechanical differences indicate that the appearance and progression of glaucoma could be associated with specific corneal biomechanical DOI: 10.1097/IJG.0000000000002170 changes, 17,18 which may offer a novel perspective on glaucoma pathology.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Corneal Biomechanics in Primary Open Angle Glaucoma and Ocular Hypertension: A Systematic Review and Meta-analysis

Liu

Zhou

et al. 2022

Journal of Glaucoma

View full text Add to dashboard Cite

Précis: Normal tension glaucoma patients had softer corneas than normal controls, whereas high-tension glaucoma and ocular hypertension patients had stiffer corneas.Purpose: To comprehensively identify the corneal biomechanical differences of patients with primary open angle glaucoma (POAG) and ocular hypertension (OHT) using the Ocular Response Analyzer or the Corvis ST. Methods:The electronic databases PubMed, Embase, and Web of Science were comprehensively searched for studies comparing corneal biomechanical differences between POAG and OHT patients with normal controls by Ocular Response Analyzer or Corvis ST. The weighted mean differences and 95% confidence intervals (CIs) were calculated. Subgroup analyses were performed according to the subtypes of POAG, including high-tension glaucoma (HTG) and normal tension glaucoma (NTG).Results: Thirty-one case-control studies were ultimately included, with 2462 POAG patients, 345 OHT patients, and 3281 normal controls. The corneal hysteresis (CH), corneal resistance factor (CRF), and highest concavity time (HC-t) were all lower in POAG patients than in normal controls. The CH, time at the second applanation (A2t), HC-t, highest concavity radius (HC-R), and deformation amplitude at the highest concavity (HC-DA) were lower in OHT patients, while the CRF, time at the first applanation (A1t), and stiffness parameter at the first applanation (SP-A1) were greater in OHT patients than in normal controls. The subgroup analyses showed that the CH, A2t, length at the second applanation (A2L), and HC-DA were lower in HTG, and the CH, CRF, A1t, and HC-t were lower in NTG patients than in normal controls. Conclusion:The corneas of NTG patients are more deformable than normal controls, whereas the corneas of HTG and OHT patients are stiffer.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Corneal Biomechanics in Primary Open Angle Glaucoma and Ocular Hypertension: A Systematic Review and Meta-analysis

Liu

Zhou

et al. 2022

Journal of Glaucoma

View full text Add to dashboard Cite

show abstract

“…On the other hand, factors such as SP-A1, SP-HC, or SSI, which were less affected by IOP, were not included in their analysis [14]. Table 2 summarizes major studies evaluating corneal biomechanics in glaucoma/OHT patients using Corvis ST [33,39,70,[88][89][90][91][92][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107]. Few studies compared the corneal biomechanics of OHT patients versus POAG patients using Corvis ST. Silva and colleagues demonstrated that OHT eyes had less deformable "stiffer" corneas based on significantly higher SP-A1 compared to POAG patients (p = 0.04), although subjects were not stratified into HTG and NTG [103].…”

Section: Clinical Studies Using Corneal Visualization Scheimpflug Tec...mentioning

confidence: 99%

Corneal Biomechanical Measures for Glaucoma: A Clinical Approach

Elhusseiny,

Scarcelli,

Saeedi

2023

Bioengineering

View full text Add to dashboard Cite

Over the last two decades, there has been growing interest in assessing corneal biomechanics in different diseases, such as keratoconus, glaucoma, and corneal disorders. Given the interaction and structural continuity between the cornea and sclera, evaluating corneal biomechanics may give us further insights into the pathogenesis, diagnosis, progression, and management of glaucoma. Therefore, some authorities have recommended baseline evaluations of corneal biomechanics in all glaucoma and glaucoma suspects patients. Currently, two devices (Ocular Response Analyzer and Corneal Visualization Schiempflug Technology) are commercially available for evaluating corneal biomechanics; however, each device reports different parameters, and there is a weak to moderate agreement between the reported parameters. Studies are further limited by the inclusion of glaucoma subjects taking topical prostaglandin analogues, which may alter corneal biomechanics and contribute to contradicting results, lack of proper stratification of patients, and misinterpretation of the results based on factors that are confounded by intraocular pressure changes. This review aims to summarize the recent evidence on corneal biomechanics in glaucoma patients and insights for future studies to address the current limitations of the literature studying corneal biomechanics.

show abstract

Evaluation of a New All-in-One Optical Biometer and Comparison With a Validated Swept-source OCT Biometer

Li,

Zou,

et al. 2023

J Refract Surg

View full text Add to dashboard Cite

Purpose: To assess agreement between a new all-in-one non-contact optical biometer based on optical low coherence reflectometry (SW-9000 µm Plus; Suoer) and a swept-source optical coherence tomography biometer (OA-2000; Tomey). Methods: Each eye was scanned three times in a row by each device at random. The measured ocular parameters included central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), axial length (AL), flat keratometry (Kf), steep keratometry (Ks), mean keratometry (Km), astigmatism, corneal diameter (CD), and pupil diameter (PD). The paired t test was used to show the differences between the SW-9000 and OA-2000. Bland-Altman plots and the 95% limits of agreement (LoA) were applied to assess the consistency of the measurements. Results: Sixty eyes from 60 healthy participants were examined, with a mean spherical equivalent refraction of −5.58 ± 2.31 diopters and a mean age of 30.40 ± 6.07 years. The Bland-Altman plots showed high agreement for AL, ACD, LT, Kf, Ks, Km, astigmatism, and CD measurements (95% LoA: −0.06 to 0.04 mm, −0.10 to 0.06 mm, −0.12 to 0.11 mm, −0.30 to 0.29 D, −0.35 to 0.38 D, −0.29 to 0.30 D, −0.30 to 0.34 D, and −0.50 to 0.06 mm, respectively), whereas the agreement for CCT and PD were moderate (95% LoA: 7.12 to 20.43 µm, −0.75 to 1.19 mm, respectively). Conclusions: The new all-in-one non-contact biometer had high agreement with the OA-2000 biometer on the AL, ACD, LT, Kf, Ks, Km, astigmatism, and CD measurements. For most of the ocular parameters assessed, they were clinically interchangeable. [ J Refract Surg . 2023;39(12):825–830.]

show abstract

Comparing corneal biomechanics and intraocular pressure between healthy individuals and glaucoma subtypes: A cross-sectional study

Cited by 3 publications

References 11 publications

Corneal Biomechanics in Primary Open Angle Glaucoma and Ocular Hypertension: A Systematic Review and Meta-analysis

Corneal Biomechanics in Primary Open Angle Glaucoma and Ocular Hypertension: A Systematic Review and Meta-analysis

Corneal Biomechanical Measures for Glaucoma: A Clinical Approach

Evaluation of a New All-in-One Optical Biometer and Comparison With a Validated Swept-source OCT Biometer

Contact Info

Product

Resources

About