Updated Understanding of the Degenerative Disc Diseases - Causes Versus Effects - Treatments, Studies and Hypothesis

Muresanu, Cristian; Somasundaram, Siva G; Neganova, Margarita E.; Bovina, Elena; Vissarionov, Sergei V.; Ofodile, Okom; Фисенко, Владимир Петрович; Bragin, Valentin; Minyaeva, Nina N.; Chubarev, Vladimir N.; Клочков, С. Г.; Tarasov, Vadim V.; Mikhaleva, L.M.; Aliev, Gjumrakch

doi:10.2174/1389202921999200407082315

Cited by 2 publications

(1 citation statement)

References 102 publications

(50 reference statements)

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“…The clinical implications of discopathies in symptomatic patients consist of bouts of chronic low back pain, weakness in the lower limbs, tingling and numbness of the extremities and increased pain depending on the movement performed, with impairment of the individual's quality of life, which can be treated in invasive or noninvasive 17 .…”

Section: Introductionmentioning

confidence: 99%

Percutaneous lumbar discectomy: a systematic review

Campos

Rodrigues

Salatii

et al. 2023

jhgd

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Introduction: low back pain is a clinical condition with a multifactorial etiopathogenesis, which has a high socioeconomic impact, especially in the economically active population, as it is associated with frequent absenteeism and reduced quality of life. Through intervertebral disc degeneration, a progressive instability of the compromised region is observed, triggering a harmful positive feedback mechanism that further promotes intervertebral disc disease. Built by the interaction between the predisposing biopsychosocial components, a multidisciplinary therapeutic proposition is suggested. In persistent low back pain, treatment involves surgical procedures such as Percutaneous Lumbar Discectomy. Objective: to evaluate the scientific evidence regarding the clinical outcomes and safety of this surgery. Methods: systematic review duly registered in Prospero (CRD42022370811), based on the PICOD question, elaborated from a Boolean search in different databases for scientific articles, evaluated and selected in a paired way based on the eligibility criteria. In addition to extracting data related to the proposed objectives, the articles included were evaluated in relation to their level of evidence and strength of recommendation. Results: among the 12 articles included, it was observed that it is a clinically effective and safe procedure. In the set of evidences gathered, they are of high and moderate level of evidence with respective strength of recommendation strong/good and weak/moderate. Conclusion: Percutaneous Lumbar Discectomy promotes significant reduction of pain and increase in body functionality, in addition to preserving local musculoskeletal structures and preventing post-surgical joint instability. It is, therefore, a safe and clinically effective minimally invasive procedure for patients with herniated discs.

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Section: Introductionmentioning

confidence: 99%

Percutaneous lumbar discectomy: a systematic review

Campos

Rodrigues

Salatii

et al. 2023

jhgd

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Hypothetical Role of Growth Factors to Reduce Intervertebral Disc Degeneration Significantly through Trained Biological Transformations

Muresanu¹,

Somasundaram

Vissarionov

et al. 2021

CPD

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Background: From the evidence of failed injection-based growth factor therapies, it has been proposed that a naturally triggered uninterrupted blood circulation of the growth factors would be superior. Objective: We seek to stimulate discussions and more research about the possibility of using the already available growth factors found in the prostate gland and endometrium by starting a novel educable physiology, known as biological transformations controlled by the mind. Methods: We summarized the stretch-gated ion channel mechanism of the cell membrane, and offer several practical methods that can be applied by anyone, in order to stimulate and enhance the blood circulation of the growth factors from the seminal fluid to sites throughout the body. This details the practical application of our earlier published studies about biological transformations. Results: A previously reported single-patient case study has been extended, adding more from his personal experiences continually improving this novel physiological training and extending the ideas from our earlier findings in detail. Conclusion: The biological transformation findings demonstrate the need additional research to establish the benefits of these natural therapies to repair and rejuvenate tissues affected by various chronic diseases or aging processes.

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Updated Understanding of the Degenerative Disc Diseases - Causes Versus Effects - Treatments, Studies and Hypothesis

Cited by 2 publications

References 102 publications

Percutaneous lumbar discectomy: a systematic review

Percutaneous lumbar discectomy: a systematic review

Hypothetical Role of Growth Factors to Reduce Intervertebral Disc Degeneration Significantly through Trained Biological Transformations

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