Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis

Kurokawa, Ichiro; Layton, Alison; Ogawa, Rei

doi:10.1007/s13555-021-00552-6

Cited by 42 publications

(86 citation statements)

References 70 publications

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“…The normal period of isotretinoin is 16-24 weeks, with increasing doses used as tolerated until the target dosage, usually between 120 and 150 mg/kg, is met. However, late teenage use has an increased risk of relapse, especially in women with hormonally induced acne and up to 20% of all younger patient populations [31,32]. In our study, 34.3% of participants take treatment for acne vulgaris (94.9% take medications regularly).…”

Section: Resultsmentioning

confidence: 60%

Acne Vulgaris among Adolescent Females in Arar City, Northern Saudi Arabia

Alenezy¹,

Alshammari²,

Alanazi³

et al. 2022

Pharmacophore

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community-based cross-sectional research was steered in Arar, Northern Saudi Arabia. Adolescent females from a secondary school that was chosen at random made up the study population. The SPSS program was used to assemble and analyze the data, and the findings were examined using frequencies and the Chi-squared test if necessary. According to our findings, 15.1% of participating females aged less than 15 and 84.9% were between 15-18 years old. 96.9% of them were Saudi, and 3.1% were non-Saudi. Acne appeared during 13-16 years of age in 59.3% of the cases. 45.9% of respondents had acne on their faces. Increased acne appearance due to consumption of certain types of food was reported in our study (46.7% fatty meals, 31.4% chocolate, 15.1% spicy food and 6.9% soft drinks). Here stayed nonsignificant connotation amid acne and age, social status, father of mother working and educational level. We established substantial connotations between smoking and the appearance of acne. Acne Vulgaris prevalence among adolescent Saudi Females is near the published figures. Acne had psychological effects on adolescent girls causing low self-confidence and depression symptoms. Awareness should be raised among this age group about the nature of the disease, appearance of acne, factors increasing and factors decreasing acne, causes of acne and treatment strategies for acne vulgaris.

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Section: Resultsmentioning

confidence: 60%

Acne Vulgaris among Adolescent Females in Arar City, Northern Saudi Arabia

Alenezy¹,

Alshammari²,

Alanazi³

et al. 2022

Pharmacophore

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“…In general, inflammation is a disease-fighting response in the body, but a persistent inflammatory response will cause cell damage and even cell apoptosis [ 25 ]. It is reported that an overproduction of NO is able to induce an inflammatory response, in which process the inflammatory cytokines’ tumor necrosis factor-α (TNF-α), interleukine-1 β (IL-1 β ), and interleukine-6 (IL-6) are secreted to exacerbate the inflammatory response [ 26 ]. An LPS-induced RAW264.7 cell inflammatory model is widely used to evaluate the anti-inflammatory effect in many studies [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition of Tobacco Seed Oils and Their Antioxidant, Anti-Inflammatory, and Whitening Activities

Gu¹,

Zhang

Song³

et al. 2022

Molecules

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Tobacco seeds are a valuable food oil resource, and tobacco seed oil is rich in nutrients, especially polyunsaturated fatty acids. The aim of this work was to perform a comprehensive study on the chemical constituents, and the antioxidant, anti-inflammatory, and whitening activities of tobacco seed oils (NC89 and BS4). A GC/MS analysis revealed that NC89 and BS4 had 11 and 6 volatile compounds, respectively. The PUFA contents in NC89 and BS4 were 74.98% and 72.84%, respectively. These two tobacco seed oils also presented good radical scavenging capacities with the neutralization of ABTS, OH−, and superoxide (O2−) radicals in a concentration-dependent manner. Meanwhile, NC89 and BS4 inhibited reactive oxygen species (ROS) accumulation and cell apoptosis, enhanced SOD and CAT activities, and increased the GSH content in H2O2-induced HepG2 cells. In addition, NC89 and BS4 exhibited significant anti-inflammatory activities by inhibiting the expressions of NO, TNF-α, IL-1β, and IL-6 in LPS-induced RAW.264.7 cells through the regulation of the MAPK signaling pathway. Moreover, NC89 and BS4 expressed whitening activities by inhibiting tyrosinase activity and intracellular melanin production. Therefore, tobacco seed oils could be used as an important oil resource for the development of high value-added products.

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“…Therefore, therapeutic approaches focus on the main factors implicated in acne, namely the androgen-mediated sebogenesis, hyperkeratinization, colonization with C. acnes and inflammation related to innate and adaptive mechanisms [ 7 ]. Current treatments depend on the severity of acne and usually vary from topical to oral systemic therapies.…”

Section: Introductionmentioning

confidence: 99%

Action of Mangifera indica Leaf Extract on Acne-Prone Skin through Sebum Harmonization and Targeting C. acnes

et al. 2022

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(1) Background: Preclinical studies report that the ethanolic fraction from Mangifera indica leaves is a potential anti-acne agent. Nevertheless, the biological activity of Mangifera indica leaves has scarcely been investigated, and additional data are needed, especially in a clinical setting, for establishing the actual effectiveness of Mangifera indica extract as an active component of anti-acne therapy. (2) Methods: The evaluation of the biological activity of Mangifera indica extract was carried out through different experimental phases, which comprised in silico, in vitro, ex vivo and clinical evaluations. (3) Results: In silico and in vitro studies allowed us to identify the phytomarkers carrying the activity of seboregulation and acne management. Results showed that Mangifera indica extract reduced lipid production by 40% in sebocytes, and an improvement of the sebum quality was reported after the treatment in analyses performed on sebaceous glands from skin explants. The evaluation of the sebum quantity and quality using triglyceride/free fatty acid analysis conducted on Caucasian volunteers evidenced a strong improvement and a reduction of porphyrins expression. The C. acnes lipase activity from a severe acne phylotype was evaluated in the presence of Mangifera indica, and a reduction by 29% was reported. In addition, the analysis of the skin microbiota documented that Mangifera indica protected the microbiota equilibrium while the placebo induced dysbiosis. (4) Conclusions: Our results showed that Mangifera indica is microbiota friendly and efficient against lipase activity of C. acnes and supports a role for Mangifera indica in the therapeutic strategy for prevention and treatment of acne.

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Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis

Cited by 42 publications

References 70 publications

Acne Vulgaris among Adolescent Females in Arar City, Northern Saudi Arabia

Acne Vulgaris among Adolescent Females in Arar City, Northern Saudi Arabia

Chemical Composition of Tobacco Seed Oils and Their Antioxidant, Anti-Inflammatory, and Whitening Activities

Action of Mangifera indica Leaf Extract on Acne-Prone Skin through Sebum Harmonization and Targeting C. acnes

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