Update über die aktuelle Diagnostik und Therapie der peripheren                arteriellen Verschlusskrankheit (pAVK)

Schürch, Kerstin A; Sixt, Sebastian; Jeanneret, Christina; Canova, Corina

doi:10.1024/0040-5930/a001028

Cited by 3 publications

(3 citation statements)

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“…The long total obliterated segments of the arteries tend to have multiple and multilevel lesions. In this case, the surgeon is more likely to use alternative access and advanced re-entry techniques [8,12].…”

Section: Discussionmentioning

confidence: 99%

“…The clinical signs and complications of peripheral artery diseases lead to severely reduced life quality. The 5-year mortality rate for these individuals is higher than those of ones with cardiovascular or cerebrovascular disease [8,9]. From 1 % to 2 % of persons with atherosclerotic lesions of lower extremities suffer from critical limb ischemia (CLI) as the most severe form of the peripheral arterial disease [2,10].…”

Section: Introductionmentioning

confidence: 99%

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Endovascular interventions in patients with multilevel steno-occlusive lesions of the infrarenal aortic arteries

Shaprynskyі¹,

Suleimanova²

2021

Eureka: HS

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Peripheral artery diseases are a worldwide medical and social problem. Approximately 30 % of patients with critical limb ischemia will undergo amputations and 25 % will die after 1 year. These patients require reconstructive and angioplastic interventions to preserve the limb. The aim of the study is to compare the effectiveness of different endovascular surgical technologies in patients with multilevel steno-occlusive lesions of the infrarenal aortic arteries. Materials and methods. Among 243 endovascular interventions, 51 patients were presented with multilevel steno-occlusive lesions of the infrarenal aortic arteries as a result of atherosclerosis obliterans. 42 patients (82.4 %) had two-level lesions and 9 (17.6 %) had three-level lesions. Results. Among 42 patients with a two-level lesion, 29 (56.9 %) ones had femoral arterial segment affection in combination with tibial artery affection. 13 (25.5 %) patients suffered from the lesion of the iliac segment in combination with the affection of the femoral segment arteries. In 9 (17.6 %) patients the lesions of three or more levels were determined: an iliac segment in combination with femoral and popliteal arteries – in 4 patients, and in 2 patients there were lesions of the femoral, popliteal and tibial segments, in 3 patients there was a lesion of the iliac, femoral, popliteal and tibial-foot segments in different degrees of severity. 7 balloon angioplasties and 13 stenting procedures were performed in two and three-level lesions in which the iliac arterial segment was affected. Only balloon angioplasty was used to revascularize the infraingvinal arterial segments. In the early postoperative period, the complications included thrombosis appeared in 6 patients. It was possible to restore the blood flow and save the limb only in 3 persons. For the other 3 ones, the attempts to restore the patency of the arteries were unsuccessful and resulted in the amputation of the lower extremity. Mortality in the early postoperative period was 3.9 % (2 death due to myocardial infarction). Conclusions. The persons with multilevel steno-obstructive lesions of the infrarenal aortic arteries are the most difficult category of patients with CLI. The surgical method of choice for patients with multilevel steno-occlusive lesions is the endovascular angioplasty with or without stenting.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Endovascular interventions in patients with multilevel steno-occlusive lesions of the infrarenal aortic arteries

Shaprynskyі¹,

Suleimanova²

2021

Eureka: HS

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“…Other symptoms include skin ulcers, bluish skin, cold skin, or abnormal nail and hair growth in the affected leg(Hooi et al, 2002). Complications may include an infection or tissue death which may require amputation; coronary artery disease, or stroke(Schurch et al, 2018).…”

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confidence: 99%

A Review Article on The Investigation of Therapeutic Potential of Sildenafil in Experimentally-Induced Hind Limb Ischemia of Diabetic Model

Tawfik

Hazem²,

Hanna³

et al. 2022

Records of Pharmaceutical and Biomedical Sciences

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Sildenafil citrate is a highly selective inhibitor of cyclic guanine monophosphate-specific phosphodiesterase type-5 (PDE-5), leads to smooth muscle relaxation, increases vascular perfusion and tissue blood flow. Clinical and experimental studies previously reported a protective effect of sildenafil in ischemic reperfusion settings in various models. Antioxidants have been reported to reduce ischemia reperfusion injury like vitamin E. Selenium (Se) is one of the most important antioxidants. Antioxidant enzymes such as thioredoxin reductase (TrxR) and glutathione peroxidase along with selenoprotein-P, are responsible for the transport and storage of Se. Nanoelemental Se (SeNPs) are more biocompatible with exhibiting a dramatic decrease in toxicity. Sildenafil and Nano selenium mediated therapeutic angiogenesis in diabetic hind limb ischemia. They improve blood supply, antioxidants delivery for cells and decrease necrosis in peripheral arterial disease (PAD). The induction of therapeutic angiogenesis by sildenafil and SeNPs achieved in this study along with resumed antioxidant defense gives hope of an alternative treatment.

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Adverse events associated with nilotinib in chronic myeloid leukemia: mechanisms and management strategies

Zeng

Jiang

Hao

et al. 2021

Expert Review of Clinical Pharmacology

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Update über die aktuelle Diagnostik und Therapie der peripheren arteriellen Verschlusskrankheit (pAVK)

Cited by 3 publications

References 0 publications

Endovascular interventions in patients with multilevel steno-occlusive lesions of the infrarenal aortic arteries

Endovascular interventions in patients with multilevel steno-occlusive lesions of the infrarenal aortic arteries

A Review Article on The Investigation of Therapeutic Potential of Sildenafil in Experimentally-Induced Hind Limb Ischemia of Diabetic Model

Adverse events associated with nilotinib in chronic myeloid leukemia: mechanisms and management strategies

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