Abstract:Sildenafil citrate is a highly selective inhibitor of cyclic guanine monophosphate-specific phosphodiesterase type-5 (PDE-5), leads to smooth muscle relaxation, increases vascular perfusion and tissue blood flow. Clinical and experimental studies previously reported a protective effect of sildenafil in ischemic reperfusion settings in various models. Antioxidants have been reported to reduce ischemia reperfusion injury like vitamin E. Selenium (Se) is one of the most important antioxidants. Antioxidant enzymes… Show more
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