Update on vasculitis

Khasnis, Atul; Langford, Carol A.

doi:10.1016/j.jaci.2009.04.024

Cited by 61 publications

(70 citation statements)

References 80 publications

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“…Sistemik küçük damar vaskülitlerinde dermal komponentin etkilenmesi de kütanöz lökositoklastik vaskülitle ayn› histolojik bulgulara neden oldu¤undan, sistemik tutulumun her hastada d›fllanmas› gereklidir 4,6,11,12 . Kütanöz lökositoklastik vaskülitli olgular›n yaklafl›k yar›s›nda idiyopatik, di¤er yar›-s›nda ilaçlar, kimyasallar, viral, bakteriyel ve fungal enfeksiyonlar, süt proteini veya gluten alerjileri, lenfoproliferatif bozukluklar, solid tümörler, konnektif doku hastal›klar›, inflamatuvar barsak hastal›klar› gibi kronik hastal›klarla iliflkilidir ( Tablo 2) 2,10, [13][14][15] . Küçük damar vasküliti düflündüren tüm olgularda özellikle de sistemik bulgular›n efllik etmedi¤i deriye s›n›rl› vaskülit tablolar›nda ilaç etyolojisi mutlaka düflü-nülmelidir.…”

Section: Küçük Damar Vaskülitleri Kütanöz Lökositoklastik Vaskülitunclassified

“…Baflvuru esnas›nda üriner analizleri normal olanlarda kal›c› renal hasar geliflmezken, bir tek tahlilde bozukluk olanlar›n %1,6's›nda kal›c› renal hasar geliflti¤i görülmüfltür. Bu nedenle ilk üriner tahlil normal olsa bile bu hastalar›n ilk alt› ayl›k dönemde izlenmeleri önerilmekte-dir 13,21 . HSP'li kad›nlarda gebelik döneminde preeklempsi ve/veya proteinüri geliflme riski vard›r 2,16,21 .…”

Section: Küçük Damar Vaskülitleri Kütanöz Lökositoklastik Vaskülitunclassified

“…Ürtikeryal vaskülit olgular›-n›n %70-80'i normo, %20-30'u ise hipokomplementemiktir 2,15 . Normokomplementemik ürtikeryal vaskülit tan›s› için hem atak s›ras›nda hem de atak sonras› dönemde en az iki-üç kez kompleman (C3, C4, CH450) düzeylerine bak›lma-l›d›r 13 . Ürtikeryal vaskülitin normokomplementemik formlar› s›kl›kla idiyopatiktir.…”

Section: üRtikeryal Vaskülitunclassified

“…Nadir görülen bu tabloda hastalarda SLE'dekine benzer flekilde plörit ve glomerülonefrit vard›r. Bu olgularda ürti-keryal vaskülit tan›s›n›n konulabilmesi için anti-C1q presipitinlerin olmas› gerekir, buna ilaveten C3 ve C4, aktif dönem-de C1q düflüktür 2,5,13,15 . Ürtikeryal vaskülitin di¤er laboratuar bulgular› aras›nda eritrosit sedimentasyon h›z› yüksekli¤i (%28), hipokomplementemi (%18), düflük titrede ANA pozitifli¤i (%30-50) ve hematüri (%29) bulunur 5 .…”

Section: üRtikeryal Vaskülitunclassified

“…Histolojik olarak lökositoklastik vaskülit özellikleri vard›r, normokomplementemik formda eozinofiller, hipokomplementemik formda yo¤un interstisyel nötrofiller izlenir 15 . Ek olarak direkt immünfloresanda dermoepidermal bileflkede ve kan damarlar›n›n çevresinde %80 olguda immünglobulin, fibrin ve kompleman bulunmaktad›r 13 . Ürtikeryal vaskülit tedavisi deri lezyonlar›n›n yo¤unlu¤una ve efllik eden sistemik bulgulara göre planlan›r.…”

Section: üRtikeryal Vaskülitunclassified

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Cutaneous Vasculitis

İlter¹,

Adışen²

2010

turkderm

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ÖzetVaskülit kan damar duvar›nda kanama ve/veya iskemik olaylara neden olan vasküler inflamasyon fleklinde tan›mlanmaktad›r. Vaskülitlerin en s›k görülen klinik bulgusu palpabl purpura olmas›na karfl›n hastalar ürtiker, infiltratif eritem, petefli, purpura, purpu- SummaryVasculitis is defined as inflammation directed at vessels, which compromises or destroys the vessel wall leading to haemorrhagic and/or ischaemic events. Although the most common clinical finding of vasculitis is palpable purpura, patients may also present with other lesions including urticaria, infiltrative erythema, petechiae, purpura, purpuric papules, haemorrhagic vesicles and bullae, nodules, livedo reticularis, deep ulcers and digital gangrene. Classification systems have been important in the study of vasculitic diseases, and the most widely accepted one is based on the size of the vessel involved. This article will focus on the most common forms of cutaneous vasculitis. (Turkderm 2010; 44: 50-60)

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Section: Küçük Damar Vaskülitleri Kütanöz Lökositoklastik Vaskülitunclassified

Section: üRtikeryal Vaskülitunclassified

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Cutaneous Vasculitis

İlter¹,

Adışen²

2010

turkderm

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Urticaria and Episcleritis in a Woman With Chronic Cough

Dai

Weinstein

2018

JAMA Dermatol

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A woman in her 30s presented with a 10-month history of painful pruritic eruption and painful red eyes. The eruption was exacerbated by stress but unrelated to time of day, ambient temperature, or sunlight exposure. Additionally, she reported edema of the dorsal hands and proximal fingers lasting approximately 8 hours during flares without any joint swelling. She also reported recent worsening of a chronic cough. She had an otherwise negative review of systems including denial of any other type of eruption, oral or nasal ulcers, seizures, chest pain, or arthritis. She had no notable medical or family history.A physical examination revealed scattered wheals distributed on her head, trunk, and extremities (Figure , A), with hyperpigmentation and petechiae. Eye examination revealed mild episcerlitis (Figure , B). A punch biopsy was performed (Figure , C and D). Blood work revealed negative results for her antinuclear antibodies (ANA) panel and low levels of C1q, C2, and C3 complement. She also had an elevated C-reactive protein and elevated levels of anti-C1q antibodies (38; normal, <20). Results of urinalysis, complete blood count, and comprehensive metabolic panel were unremarkable; C1-inhibitor levels, anti-double-stranded DNA, hepatitis B virus surface antigen, cryoglobulins, anti-neutrophil cytoplasmic antibodies, and serum protein electrophoresis were within normal limits. Diagnosis B. Hypocomplementemic urticarial vasculitis syndrome Microscopic Findings and Clinical CourseBiopsy revealed fibrin and neutrophils within blood vessel walls surrounded by leukocytoclastic debris, extravasated erythrocytes, and a Scattered hyperpigmented wheals A Original magnification × 20 C Episcleritis B Original magnification × 100 D Figure. A, Physical examination revealed multiple scattered wheals distributed over head, trunks, and extremities. B, Scleral injection of the left eye suggesting episcleritis. C and D, Hematoxylin-eosin. WHAT IS YOUR DIAGNOSIS? A. Systemic lupus erythematosus B. Hypocomplementemic urticarial vasculitis syndrome C. Neutrophilic urticaria D. Familial cold autoinflammatory syndrome Clinical Review & Education

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Nursing Care of the Hospitalized Older Patient

Buttaro¹,

Barba²

2012

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Update on vasculitis

Cited by 61 publications

References 80 publications

Cutaneous Vasculitis

Cutaneous Vasculitis

Urticaria and Episcleritis in a Woman With Chronic Cough

Nursing Care of the Hospitalized Older Patient

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