Update on Thrombocytopenia in Pregnancy

Subtil, Simone; Mendes, Jorge; Areia, Ana Luísa; Moura, Paulo

doi:10.1055/s-0040-1721350

Cited by 13 publications

(18 citation statements)

References 36 publications

(209 reference statements)

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“…On the other hand, pregnant women with severe thrombocytopenia are at a high risk to develop the bleeding disorder during and after delivery due to the normalization of coagulant activity near to the term and following delivery that can be associated with profound maternal and fetal morbidity and mortality. 22,44 Moreover, multivariate logistic regression analysis showed that residence and gestational ages (trimesters) had a statistically significant association with thrombocytopenia. Gestational ages within first trimester (AOR: 0.183, 95% CI, 0.057-0.593, P = 0.001) and gestational ages within second trimester = 0.264, 95% CI, 0.092-0.752, P = 0.009).…”

Section: Discussionmentioning

confidence: 99%

Magnitude and Associated Factors of Thrombocytopenia among Pregnant Women Attending Antenatal Care Clinics at Dessie Comprehensive Specialized Hospital, Northeast Ethiopia

Ebrahim

Kebede²,

Tilahun

et al. 2022

Clin Appl Thromb Hemost

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Background Thrombocytopenia is a common hematological abnormality during gestation. Pregnant women with severe thrombocytopenia may be associated with a higher risk of excessive bleeding during or after delivery. Therefore, the main aim of this study was to assess the magnitude and associated factors of thrombocytopenia among pregnant women attending antenatal care services at Dessie comprehensive and specialized hospital, Northeast Ethiopia. Methods An institution-based cross-sectional study was conducted from February to March 2021. Using a systematic random sampling technique, a total of 294 pregnant women were enrolled in the study. Structured interviewer-administered questionnaires were used to collect socio-demographic and clinical data of study participants. Four ml of venous blood were collected from each pregnant woman and a complete blood count was determined using DIRUI BF 6500 automated hematology analyzer. Data were entered into Epidata version 4.6.0 and then exported into SPSS version 24.0. Multivariate logistic regression was used to assess the association between dependent and independent variables. P-value < 0.05 was considered to be statistically significant. Results A total of 294 pregnant women who visited antenatal care services at Dessie comprehensive specialized hospital were included. The mean (±SD) age of the study participants was 29.7 (±6.1) years. The prevalence of thrombocytopenia among pregnant women was 9.9% (95% CI: 6.5, 13.6). A mild type of thrombocytopenia is the major type and accounted for 72.4% whereas moderate thrombocytopenia and severe thrombocytopenia accounted for 17.2% and 10.4% respectively among pregnant women. Multivariate logistic regression showed that urban residents (AOR: 0.206,95% CI, 0.055-0.748), gestational ages within the first trimester (AOR: 0.183, 95% CI, 0.057-0.593) and gestational ages within the second trimester (AOR = 0.264, 95% CI, 0.092-0.752) were significantly associated and independent predictors of thrombocytopenia in pregnant women. Conclusion In this study, the prevalence of thrombocytopenia was 9.9% and the mild type of thrombocytopenia (72.4%) was higher than the other type of thrombocytopenia among pregnant women. In multivariate logistic regression analysis, residence and gestational age (trimester) were significantly associated with thrombocytopenia. Therefore, the platelet count should be routinely determined during the antenatal care visit for proper diagnosis and to minimize bleeding during and or after childbirth.

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Section: Discussionmentioning

confidence: 99%

Magnitude and Associated Factors of Thrombocytopenia among Pregnant Women Attending Antenatal Care Clinics at Dessie Comprehensive Specialized Hospital, Northeast Ethiopia

Ebrahim

Kebede²,

Tilahun

et al. 2022

Clin Appl Thromb Hemost

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“…O enfermeiro é o profissional de saúde que pode ser fundamental na assistência multiprofissional no manejo da Síndrome HELLP e o pré-natal é o momento crucial de escuta e avaliação da paciente. Apesar da enfermagem explorar o conhecimento no contexto da obstetrícia e os seus aspectos, devido à particularidade e alta complexidade dos casos críticos, o profissional deve buscar maior eficiência no monitoramento e gerenciamento dos casos suspeitos ou confirmados de Síndrome HELLP para compreender os mecanismos, sinais e sintomas da sua ocorrência (SUBTIL et al, 2020).…”

Section: Resultsunclassified

Úlceras Venosas Em Pacientes Em Tratamento Intensivo: Revisão Integrativa

Araújo¹,

Oliveira²,

Sousa³

et al. 2022

Estudos Multidisciplinares Em Emergência E Terapia Intensiva

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Todo o conteúdo dos capítulos, dados apresentados, informações e correções ortográficas e gramaticais são de responsabilidade exclusiva dos autores, estando a Editora Creative isenta de qualquer ação de responsabilidade no que tange plágio, direcionamento de opinião ou de afirmações de qualquer natureza.O download e compartilhamento da obra são permitidos desde que os créditos sejam devidamente atribuídos aos autores. É vedada a realização de alterações na obra, assim como sua utilização para fins comerciais.Todos os manuscritos foram previamente submetidos à avaliação pelo Conselho Editorial do I Congresso Nacional em Emergência e Terapia Intensiva -CONAETI, tendo sido aprovados para a publicação.Normalização e revisão: dos autores e autoras.

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“…Risiko dari prosedur regional anestesi pada kasus trombositopenia yaitu meningkatnya risiko spinal atau epidural hematom harus menjadi pertimbangan sebelum keputusan pemilihan prosedur anestesi ditegakkan. 3 Selanjutnya akan dibahas mengenai trombositopenia pada kehamilan dan manajemen anestesi perioperatif pada kehamilan dengan trombositopenia.…”

Section: Pendahuluanunclassified

Manajemen Anestesi Perioperatif pada Kehamilan dengan Trombositopenia

Wundiawan¹,

Wiryana

2023

JAOI

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Trombositopenia dalam kehamilan adalah suatu kondisi dimana jumlah hitung trombosit kurang dari 150.000 /µL dan bisa terjadi secara fisiologis. Pada kasus kehamilan dengan trombositopenia, ada kalanya diperlukan terminasi kehamilan melalui operasi seksio sesarea. Manajemen anestesi dengan pembiusan umum dikhawatirkan berdampak buruk pada janin akibat obat atau agen anestesi yang digunakan, sedangkan manjemen anestesi dengan pembiusan regional dikhawatirkan berdampak buruk pada ibu yaitu risiko terjadinya neuraksial hematom dengan komorbid trombositopenia. Pemilihan teknik manajemen anestesi perioperatif didasarkan pada penilaian klinis pasien dan jumlah hitung trombosit dengan rentang batasan minimal yang aman untuk dilakukan tindakan regional anestesi (neuraksial) adalah 75.000 /µL–80.000 /µL. Pada kasus yang dilakukan manajemen anestesi dengan pembiusan umum, dapat dipertimbangkan dilakukan induksi dengan pemberian opioid untuk menekan dan menumpulkan rangsang simpatis saat dilakukan laringoskopi intubasi yang bertujuan mencegah komplikasi seperti perdarahan intra-serebral. Trombositopenia pada kehamilan dapat memperberat kehamilan itu sendiri namun pada umumnya persalinan berjalan lancar dan memberikan hasil akhir yang baik. Kolaborasi antara interdisiplin secara komprehensif dan holistik diperlukan untuk menangani kasus ini mulai dari perencanaan tindakan, tatalaksana dan pencegahan komplikasi pada ibu dan janin. Tidak diragukan lagi, kasus gravida dengan trombositopenia merupakan tantangan unik bagi tim anestesi. Dengan terus berkembangnya ilmu dan penelitian dibidang ini, masih perlu dibuat panduan dan batasan yang jelas terkait manajemen perioperatif pada pasien gravida dengan trombositopenia.

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Update on Thrombocytopenia in Pregnancy

Cited by 13 publications

References 36 publications

Magnitude and Associated Factors of Thrombocytopenia among Pregnant Women Attending Antenatal Care Clinics at Dessie Comprehensive Specialized Hospital, Northeast Ethiopia

Magnitude and Associated Factors of Thrombocytopenia among Pregnant Women Attending Antenatal Care Clinics at Dessie Comprehensive Specialized Hospital, Northeast Ethiopia

Úlceras Venosas Em Pacientes Em Tratamento Intensivo: Revisão Integrativa

Manajemen Anestesi Perioperatif pada Kehamilan dengan Trombositopenia

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