Update on research and activities at the Centers for Disease Control and Prevention, and the Agency for Toxic Substances and Disease Registry

Kleiman, Richard; Rentz, E. Danielle; Teshale, Eyasu; Thompson, Nicola D.; Schurz-Rogers, Helen

doi:10.1007/bf03161201

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…1,2-Dehydropyrrolizidine ester alkaloids (dehydroPAs) have been known for almost a century to be the cause of large and recurring episodes of acute hepatotoxicity in a number of countries. − The alkaloids responsible for these outbreaks of poisoning are produced by weeds that often infest grain crops, and the primary cause is consumption of bread made using dehydroPA-contaminated flour. Typical infestations of dehydroPA plants are shown in Figure .…”

Section: Introductionmentioning

confidence: 99%

Pyrrolizidine Alkaloids: Potential Role in the Etiology of Cancers, Pulmonary Hypertension, Congenital Anomalies, and Liver Disease

Edgar

Molyneux

Colegate

2014

Chem. Res. Toxicol.

173

169

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Large outbreaks of acute food-related poisoning, characterized by hepatic sinusoidal obstruction syndrome, hemorrhagic necrosis, and rapid liver failure, occur on a regular basis in some countries. They are caused by 1,2-dehydropyrrolizidine alkaloids contaminating locally grown grain. Similar acute poisoning can also result from deliberate or accidental consumption of 1,2-dehydropyrrolizidine alkaloid-containing herbal medicines, teas, and spices. In recent years, it has been confirmed that there is also significant, low-level dietary exposure to 1,2-dehydropyrrolizidine alkaloids in many countries due to consumption of common foods such as honey, milk, eggs, salads, and meat. The level of 1,2-dehydropyrrolizidine alkaloids in these foods is generally too low and too intermittent to cause acute toxicity. However, these alkaloids are genotoxic and can cause slowly developing chronic diseases such as pulmonary arterial hypertension, cancers, cirrhosis, and congenital anomalies, conditions unlikely to be easily linked with dietary exposure to 1,2-dehydropyrrolizidine alkaloids, especially if clinicians are unaware that such dietary exposure is occurring. This Perspective provides a comprehensive review of the acute and chronic toxicity of 1,2-dehydropyrrolizidine alkaloids and their potential to initiate certain chronic diseases, and suggests some associative considerations or indicators to assist in recognizing specific cases of diseases that may have resulted from dietary exposure to these hazardous natural substances. If it can be established that low-level dietary exposure to 1,2-dehydropyrrolizidine alkaloids is a significant cause of some of these costly and debilitating diseases, then this should lead to initiatives to reduce the level of these alkaloids in the food chain.

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Section: Introductionmentioning

confidence: 99%

Pyrrolizidine Alkaloids: Potential Role in the Etiology of Cancers, Pulmonary Hypertension, Congenital Anomalies, and Liver Disease

Edgar

Molyneux

Colegate

2014

Chem. Res. Toxicol.

173

169

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Toxicology, Environmental Health, and the “One Health” Concept

Buttke

2011

J. Med. Toxicol.

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The One Health concept promotes collaboration among veterinarians, physicians, scientists, and other professions to promote human, animal, and ecosystem health. One Health illustrates the interconnectedness and interdependence of human, animal, and ecosystem health. This concept has traditionally focused on zoonoses that are infectious diseases, not on chemical-or poison-related illnesses in animals and their relationship to the detection and prevention of human illness. The purpose of this article is to describe key experiences of scientists in the Health Studies Branch within the National Center for Environmental of Health of the Centers for Disease Control and Prevention in which the study of animal illness facilitated a public health investigation into an outbreak of chemicalassociated human disease. The experiences highlight how utilizing the One Health approach may improve chemicalassociated outbreak investigations and facilitate appropriate intervention strategies. An appropriate One Health approach in toxicology and environmental health in outbreak settings should include consideration of the common environments and food sources shared by humans and animals and consideration of the potential for contaminated animal products as food sources in human exposures.

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Hirmi Valley liver disease: A disease associated with exposure to pyrrolizidine alkaloids and DDT

Robinson

Want

Coen

et al. 2014

Journal of Hepatology

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Update on research and activities at the Centers for Disease Control and Prevention, and the Agency for Toxic Substances and Disease Registry

Cited by 5 publications

References 12 publications

Pyrrolizidine Alkaloids: Potential Role in the Etiology of Cancers, Pulmonary Hypertension, Congenital Anomalies, and Liver Disease

Pyrrolizidine Alkaloids: Potential Role in the Etiology of Cancers, Pulmonary Hypertension, Congenital Anomalies, and Liver Disease

Toxicology, Environmental Health, and the “One Health” Concept

Hirmi Valley liver disease: A disease associated with exposure to pyrrolizidine alkaloids and DDT

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