Update on rabbit haemorrhagic disease virus 2‐like variant in Great Britain

McGowan, Sarah; Choudhury, Bhudipa

doi:10.1136/vr.i3449

Cited by 3 publications

(4 citation statements)

References 3 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All 37 rabbits that were tested for RHDV1 showed a negative result, suggesting that RHDV2 is replacing RHDV1 as the cause of RHD in the UK. This is the conclusion of several other authors (Westcott & Choudhury 2015, McGowan & Choudhury 2016, Marschang et al 2018. Replacement of RHDV1 by RHDV2 is occurring throughout Europe, although RHDV1 was still detected in a small number of cases in Germany and the Netherlands in 2016/17 (Marschang et al 2018).…”

Section: Discussionsupporting

confidence: 64%

RHDV2 epidemic in UK pet rabbits. Part 2: PCR results and correlation with vaccination status

Harcourt-Brown

Harcourt‐Brown

Joudou³

2020

J of Small Animal Practice

View full text Add to dashboard Cite

To report PCR results and vaccination status of rabbits with rabbit haemorrhagic disease following an investigation into sudden or unexpected death. Materials and MethOds: PCR testing for RHDV2 and RHDV1 was performed on rabbit liver samples at two laboratories. Laboratory A reported results as positive or negative; Laboratory B reported results quantitatively as RNA copies per mg liver, categorised as negative, inconclusive or positive. The vaccination status of rabbits with both histopathological features of rabbit haemorrhagic disease and positive PCR test results were collated. results: PCR results matched histopathological findings in 188 of 195 (96%) cases. Seven individuals showed equivocal results, all of which had histopathological features of RHD but three tested PCRnegative and four results conflicted between laboratories. RHDV2 was the serotype detected in all PCR-positive cases. Histological features of rabbit haemorrhagic disease and PCR test results were positive in 125 rabbits; 51 unvaccinated, 56 in-date with Nobivac Myxo-RHD and 13 vaccinated against RHDV2-although nine of these were vaccinated within 10 days of death. clinical significance: PCR testing complements histopathology in cases of sudden death in rabbits by confirming the diagnosis and identifying virus serotype, but there can be false negatives. Although RHDV2 is currently prevalent in UK pet rabbits, vaccination against both RHDV1 and RHDV2 is recommended. Failures of RHDV2 vaccine are infrequent.

show abstract

Section: Discussionsupporting

confidence: 64%

RHDV2 epidemic in UK pet rabbits. Part 2: PCR results and correlation with vaccination status

Harcourt-Brown

Harcourt‐Brown

Joudou³

2020

J of Small Animal Practice

View full text Add to dashboard Cite

show abstract

“…All RHDV genotypes of the G1–G6 genogroups, hereafter referred to as RHDV, belong to the same antigenic serotype (Le Gall‐Reculé and others 2013). The unique antigenic nature of RHDV2 (Le Gall‐Reculé and others 2013, Bárcena and others 2015) is reflected in its capacity to kill rabbits vaccinated against RHDV (Le Gall‐Reculé and others 2011, Dalton and others 2014, McGowan and Choudhury 2016) and its rapid spread in Europe (Dalton and others 2012, Le Gall‐Reculé and others 2013, Abrantes and others 2014, Baily and others 2014, Westcott and others 2014) and Australia (Hall and others 2015) with associated peaks in RHD epizootics. The capacity of RHDV2 to overcome RHDV immunity, reported so far only in vaccinated rabbits, may partly explain the observed decline in wild rabbit populations where RHDV had already been circulating.…”

Section: Rabbit Number Age (Days) Date Body Mass (G) Myxomatosis Antimentioning

confidence: 99%

“…With the emergence and spread of RHDV2 in Europe, its capacity to overcome vaccination in farmed and pet rabbits was reported (Le Gall‐Reculé and others 2011, Dalton and others 2014, McGowan and Choudhury 2016). Similar cases were also detected in South Australia; 11 samples from domestic or farmed rabbits that died in the 2015–2016 RHDV2 epizootic were reported to have been vaccinated with the Cylap vaccine but tested positive for RHDV2.…”

Section: Rabbit Number Age (Days) Date Body Mass (G) Myxomatosis Antimentioning

confidence: 99%

RHDV2 overcoming RHDV immunity in wild rabbits (Oryctolagus cuniculus) in Australia

et al. 2017

View full text Add to dashboard Cite

“…Initial reports from domestic rabbit farms indicated that RHDV2 caused higher mortality in juveniles than earlier RHDV strains and killed some RHDV‐vaccinated domestic adults 2 18 19 . However, initial laboratory challenge studies in susceptible adult rabbits found RHDV2 caused much lower and more variable mortality rates and a longer time to death than were known from RHDV 8 20 .…”

Section: Introductionmentioning

confidence: 99%

Substantial numerical decline in South Australian rabbit populations following the detection of rabbit haemorrhagic disease virus 2

Mutze

Preu²,

Mooney³

et al. 2018

Veterinary Record

View full text Add to dashboard Cite

GI.2, also commonly known as rabbit haemorrhagic disease virus 2, was first detected at two long-term monitoring sites for European rabbits, , in South Australia, in mid-2016. Numbers of rabbits in the following 12-18 months were reduced to approximately 20 per cent of average numbers in the preceding 10 years. The impact recorded at the two South Australian sites, if widespread in Australia and persistent for several years, is likely to be of enormous economic and environmental benefit.

show abstract

Update on rabbit haemorrhagic disease virus 2‐like variant in Great Britain

Cited by 3 publications

References 3 publications

RHDV2 epidemic in UK pet rabbits. Part 2: PCR results and correlation with vaccination status

RHDV2 epidemic in UK pet rabbits. Part 2: PCR results and correlation with vaccination status

RHDV2 overcoming RHDV immunity in wild rabbits (Oryctolagus cuniculus) in Australia

Substantial numerical decline in South Australian rabbit populations following the detection of rabbit haemorrhagic disease virus 2

Contact Info

Product

Resources

About