Update on Pregnancy in Chronic Kidney Disease

Abstract

The occurrence of pregnancy in patients with chronic kidney disease (CKD) has been considered a dangerous event both for the mother and for the fetus. However, increasing evidence shows that the stage of CKD is the leading factor that can predict possible acceleration in the declining of renal function and complications of pregnancy. This review summarizes recent data on pregnancy in patients with CKD, dialysis and kidney transplantation.

Managing pregnancy in chronic kidney disease: improving outcomes for mother and baby

“…Key differentiating features include the typical rash, arthritis, hematuria, low complement levels in SLE, or the presence of antiphospholipid antibodies, while abnormal liver function tests suggest preeclampsia rather than SLE flare. 30 , 31 Overall, the prognosis for women with SLE nephritis has improved since the 1960s, with fetal loss rates decreasing from 40% in 1960 to 17% in 2000. 30 …”

“… 30 , 31 Overall, the prognosis for women with SLE nephritis has improved since the 1960s, with fetal loss rates decreasing from 40% in 1960 to 17% in 2000. 30 …”

“… 60 Therefore, aspirin is recommended in women with hypertension and CKD, particularly women with SLE. 30 …”

Successful Delivery in a Patient with Antineutrophil Cytoplasmic Antibody-associated Glomerulonephritis

“…The three major risk factors for complications in offspring have been reported to be a low eGFR, hypertension and proteinuria. The combination of these risk factors multiplies the risks for offspring (7,8).…”

“…Therefore, pregnancy in patients with ANCA-associated glomerulonephritis is rare, and information regarding the management of ANCA-associated glomerulonephritis during pregnancy is limited. Moreover, pregnancy in patients with a low estimated glomerular filtration rate (eGFR) for any reason accelerates declines in the kidney function accompanied with a high rate of obstetrical complications (1)(2)(3)(4)(5)(6)(7)(8).…”