Update on neuroblastoma

Newman, Erika A.; Abdessalam, Shahab; Aldrink, Jennifer H.; Austin, Mary T.; Heaton, Todd E.; Bruny, Jennifer; Ehrlich, Peter F.; Dasgupta, Roshni; Baertschiger, Reto M.; Lautz, Timothy B.; Rhee, Daniel S.; Langham, Max R.; Malek, Marcus M.; Meyers, Rebecka L.; Nathan, Jaimie D.; Weil, Brent R.; Polites, Stephanie F.; Madonna, Mary Beth

doi:10.1016/j.jpedsurg.2018.09.004

Cited by 130 publications

(143 citation statements)

References 64 publications

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“…To understand molecular basis and behavior of NB, research has been done on its genetic and biological characteristics. For updates in NB, see the reviews of Newman and Nuchtern, and Newman et al, [37,38]. Still, data on metabolic alterations in this cancer are scarce.…”

Section: Neuroblastoma (Nb)mentioning

confidence: 99%

Insights into the Chemical Biology of Childhood Embryonal Solid Tumors by NMR-Based Metabolomics

et al. 2019

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Most childhood cancers occur as isolated cases and show very different biological behavior when compared with cancers in adults. There are some solid tumors that occur almost exclusively in children among which stand out the embryonal solid tumors. These cancers main types are neuroblastoma, nephroblastoma (Wilms tumors), retinoblastoma and hepatoblastomas and tumors of the central nervous system (CNS). Embryonal solid tumors represent a heterogeneous group of cancers supposedly derived from undifferentiated cells, with histological features that resemble tissues of origin during embryogenesis. This key observation suggests that tumorigenesis might begin during early fetal or child life due to the errors in growth or pathways differentiation. There are not many literature data on genomic, transcriptomic, epigenetic, proteomic, or metabolomic differences in these types of cancers when compared to the omics- used in adult cancer research. Still, metabolomics by nuclear magnetic resonance (NMR) in childhood embryonal solid tumors research can contribute greatly to understand better metabolic pathways alterations and biology of the embryonal solid tumors and potential to be used in clinical applications. Different types of samples, such as tissues, cells, biofluids, mostly blood plasma and serum, can be analyzed by NMR to detect and identify cancer metabolic signatures and validated biomarkers using enlarged group of samples. The literature search for biomarkers points to around 20–30 compounds that could be associated with pediatric cancer as well as metastasis.

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Section: Neuroblastoma (Nb)mentioning

confidence: 99%

Insights into the Chemical Biology of Childhood Embryonal Solid Tumors by NMR-Based Metabolomics

et al. 2019

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“…Neuroblastoma is an embryonic cancer arising from neural crest stem cells. [1] The main population suffering from the tumour disease is children under 5 years old. [2] In the United States, children with extracranial tumours account for approximately one-twelfth of all paediatric cancers and approximately one-sixth of childhood cancer deaths.…”

Section: Introductionmentioning

confidence: 99%

“…[2] In the United States, children with extracranial tumours account for approximately one-twelfth of all paediatric cancers and approximately one-sixth of childhood cancer deaths. [1] Although the current patient survival rate has increased a lot, there are still some patients with metastatic high-risk diseases that are difficult to cure.…”

Section: Introductionmentioning

confidence: 99%

Meriolin1 induces cell cycle arrest, apoptosis, autophagy and targeting the Akt/MAPKs pathways in human neuroblastoma SH-SY5Y cells

Wang

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Meriolins, a kind of chemical hybrid between meridianins and variolins, have lately been determined as kinase inhibitors and reportedly have antitumour activity. However, there is currently no in‐depth study for the action mechanism. This study aimed to elucidate the potentially antitumour action mechanism of Meriolin1 on human neuroblastoma (SH‐SY5Y) cells. Methods Firstly, cell viability was detected by MTT assay. Secondly, cell cycle, cell apoptosis, cell autophagy, reactive oxygen species and mitochondrial membrane potential (ΔΨm) were measured by flow cytometry. Then, cell cycle‐associated proteins, Bcl‐2 family proteins, Akt/MAPK proteins and autophagy‐associated proteins expressions were evaluated by Western blot. Bcl‐2 and Bax mRNA expressions were also evaluated by qRT‐PCR. Furthermore, cell adhesion assay and Hoechst 33258 fluorescent staining were carried out to detect the effect of Meriolin1 on cell adhesion and morphology. Finally, to gain further insight into mechanism of action of Meriolin1 to CDK protein, the molecular docking study was performed by using the CDOCKER module of DS software. Key findings Meriolin1 could exert the antitumour activity on SH‐SY5Y cells by inducing cell cycle arrest, cell autophagy, the mitochondrion‐dependent cell apoptosis and targeting the Akt/MAPKs signalling pathway. Conclusions Meriolin1 might be a promising therapeutic candidate for neuroblastoma.

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“…1 It mainly develops from neural crest progenitor cells. 2,3 Neuroblastoma constitutes about 8%-10% of all paediatric cancers, but disproportionally causes 12%-15% cancer death in children. 2,4,5 Neuroblastoma displays considerable clinical heterogeneity, ranging from spontaneous recovery to therapy-refractory progression.…”

Section: Introductionmentioning

confidence: 99%

“…2,3 Neuroblastoma constitutes about 8%-10% of all paediatric cancers, but disproportionally causes 12%-15% cancer death in children. 2,4,5 Neuroblastoma displays considerable clinical heterogeneity, ranging from spontaneous recovery to therapy-refractory progression. 6,7 The distinct difference in survival rate among subgroups was another reflection of such heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

LIN28A gene polymorphisms modify neuroblastoma susceptibility: A four‐centre case‐control study

Hua

Zhang

et al. 2019

J Cellular Molecular Medi

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Neuroblastoma ranks the most common seen solid tumour in childhood. Overexpression of LIN28A gene has been linked to the development of multiple human malignancies, but the relationship between LIN28A single nucleotide polymorphisms (SNPs) and neuroblastoma susceptibility is still under debate. Herein, we evaluated the correlation of four potentially functional LIN28A SNPs (rs3811464 G>A, rs3811463 T>C, rs34787247 G>A, and rs11247957 G>A) and neuroblastoma susceptibility in 505 neuroblastoma patients and 1070 controls from four independent hospitals in China. The correlation strengths were determined by using odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Among these SNPs, rs34787247 G>A exhibited a significant association with increased susceptibility in neuroblastoma (GA vs GG: adjusted OR = 1.30, 95% CI = 1.03‐1.64; AA vs GG: adjusted OR = 2.51, 95% CI = 1.36‐4.64, AA/GA vs GG: adjusted OR = 1.42, 95% CI = 1.12‐1.80, AA vs GG/GA: adjusted OR = 2.39, 95% CI = 1.29‐4.42). Furthermore, the combined analysis of risk genotypes revealed that subjects carrying three risk genotypes (adjusted OR = 1.64, 95% CI = 1.02‐2.63) are more inclined to develop neuroblastoma than those without risk genotype, and so do carriers of 1‐4 risk genotypes (adjusted OR = 1.26, 95% CI = 1.01‐1.56). Stratification analysis further revealed risk effect of rs3811464 G>A, rs34787247 G>A and 1‐4 risk genotypes in some subgroups. Haplotype analysis of these four SNPs yields two haplotypes significantly correlated with increased neuroblastoma susceptibility. Overall, our finding indicated that LIN28A SNPs, especially rs34787247 G>A, may increase neuroblastoma risk.

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Update on neuroblastoma

Cited by 130 publications

References 64 publications

Insights into the Chemical Biology of Childhood Embryonal Solid Tumors by NMR-Based Metabolomics

Insights into the Chemical Biology of Childhood Embryonal Solid Tumors by NMR-Based Metabolomics

Meriolin1 induces cell cycle arrest, apoptosis, autophagy and targeting the Akt/MAPKs pathways in human neuroblastoma SH-SY5Y cells

LIN28A gene polymorphisms modify neuroblastoma susceptibility: A four‐centre case‐control study

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