Meriolin1 induces cell cycle arrest, apoptosis, autophagy and targeting the Akt/MAPKs pathways in human neuroblastoma SH-SY5Y cells

Su, Dan; Wang, Wenbin; Wu, Xinyue; Li, Minyue; Yan, Xue-Long; Hua, Zhonghong; Liu, Jiahui; Zhu, Zhiyu; Hu, Kun; Ren, Jie

doi:10.1111/jphp.13224

Cited by 6 publications

(3 citation statements)

References 50 publications

(94 reference statements)

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“…Additionally, the NF-kB and STAT3 pathways are the chemopreventive mechanisms of andrographolide via inhibition of inflammatory mediators (237). Moreover, treatment with celastrol (Figure 5) downregulated NF-kB and reduced the expression of IL-6 in prostate and breast cancer cells (238,239). In a similar study, actein (Figure 5) strongly suppressed the growth of MDA-MB-453 cells by enhancing the cytoplasmic calcium and modulating the MAPK/ERK kinase (MEK) and NF-kB pathways (240).…”

Section: Flavopiridolmentioning

confidence: 99%

Modulation of TLR/NF-κB/NLRP Signaling by Bioactive Phytocompounds: A Promising Strategy to Augment Cancer Chemotherapy and Immunotherapy

et al. 2022

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BackgroundTumors often progress to a more aggressive phenotype to resist drugs. Multiple dysregulated pathways are behind this tumor behavior which is known as cancer chemoresistance. Thus, there is an emerging need to discover pivotal signaling pathways involved in the resistance to chemotherapeutic agents and cancer immunotherapy. Reports indicate the critical role of the toll-like receptor (TLR)/nuclear factor-κB (NF-κB)/Nod-like receptor pyrin domain-containing (NLRP) pathway in cancer initiation, progression, and development. Therefore, targeting TLR/NF-κB/NLRP signaling is a promising strategy to augment cancer chemotherapy and immunotherapy and to combat chemoresistance. Considering the potential of phytochemicals in the regulation of multiple dysregulated pathways during cancer initiation, promotion, and progression, such compounds could be suitable candidates against cancer chemoresistance.ObjectivesThis is the first comprehensive and systematic review regarding the role of phytochemicals in the mitigation of chemoresistance by regulating the TLR/NF-κB/NLRP signaling pathway in chemotherapy and immunotherapy.MethodsA comprehensive and systematic review was designed based on Web of Science, PubMed, Scopus, and Cochrane electronic databases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed to include papers on TLR/NF-κB/NLRP and chemotherapy/immunotherapy/chemoresistance by phytochemicals.ResultsPhytochemicals are promising multi-targeting candidates against the TLR/NF-κB/NLRP signaling pathway and interconnected mediators. Employing phenolic compounds, alkaloids, terpenoids, and sulfur compounds could be a promising strategy for managing cancer chemoresistance through the modulation of the TLR/NF-κB/NLRP signaling pathway. Novel delivery systems of phytochemicals in cancer chemotherapy/immunotherapy are also highlighted.ConclusionTargeting TLR/NF-κB/NLRP signaling with bioactive phytocompounds reverses chemoresistance and improves the outcome for chemotherapy and immunotherapy in both preclinical and clinical stages.

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Section: Flavopiridolmentioning

confidence: 99%

Modulation of TLR/NF-κB/NLRP Signaling by Bioactive Phytocompounds: A Promising Strategy to Augment Cancer Chemotherapy and Immunotherapy

et al. 2022

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“…However, although marine natural products are very useful from a pharmacological point of view, it is very difficult to obtain these compounds from a technical and biological point of view. At present, the chemical synthesis of the effective components of marine products has become the current research hotspot [5]. After analyzing the overlapping structure of natural marine products Meridianins and Variolins, marine biologists designed and synthesized Meriolins, which has been proved to be a new kinase inhibitor that can enhance protein kinase selectivity and cell death [6][7].…”

Section: Introductionmentioning

confidence: 99%

A Novel Synthesis Method of Meriolin1

Ren¹,

Ding²,

Zhou³

et al. 2023

AJST

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Meriolins, a compound designed and synthesized by the similar structure of natural marine products Meridianins and Variolins, has been proved to be a new kinase inhibitor that can enhance protein kinase selectivity and cell death. It has stronger inhibitory activity, relative selectivity to kinases and antitumor effect. As the first compound in the Meriolins series, Meriolin1 has been studied the most. In this paper, the synthesis methods of Meriolin1 at home and abroad were summarized and analyzed. On this basis, a more economical and effective synthesis route was designed, that is, Meriolin1 was finally obtained from 7-azaindole through Friedel-crafts acylation, protection, aldol condensation and cyclization reaction. This route avoids the disadvantages of the existing routes and has the advantages of mild reaction conditions, simple operation and low cost. The structures of the compounds were confirmed by 1H NMR and 13C NMR.

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“…Apoptosis is a programmed cell death (PCD) process that occurs following the stimulation of cells by various death signals, which is characterized by caspase-dependent, cellular contraction, and the formation of apoptotic body ( Su et al, 2020 ). Currently, the majority of chemotherapeutic drugs inhibit the growth of cancer cells by inducing apoptosis, thus providing treatment for various malignancies.…”

Section: Introductionmentioning

confidence: 99%

Targeting of non-apoptotic cancer cell death mechanisms by quercetin: Implications in cancer therapy

Yang

Xu²,

Tang³

et al. 2022

Front. Pharmacol.

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The ultimate goal of cancer treatment is to kill cancer cells, based on the use of various therapeutic agents, such as chemotherapy, radiotherapy, or targeted therapy drugs. Most drugs exert their therapeutic effects on cancer by targeting apoptosis. However, alterations in apoptosis-related molecules and thus assisting cells to evade death, eventually lead to tumor cell resistance to therapeutic drugs. The increased incidence of non-apoptotic cell death modes such as induced autophagy, mitotic catastrophe, senescence, and necrosis is beneficial to overcoming multidrug resistance mediated by apoptosis resistance in tumor cells. Therefore, investigating the function and mechanism of drug-induced non-apoptotic cell death modes has positive implications for the development of new anti-cancer drugs and therapeutic strategies. Phytochemicals show strong potential as an alternative or complementary medicine for alleviating various types of cancer. Quercetin is a flavonoid compound widely found in the daily diet that demonstrates a significant role in inhibiting numerous human cancers. In addition to direct pro-tumor cell apoptosis, both in vivo and in vitro experiments have shown that quercetin exerts anti-tumor properties by triggering diverse non-apoptotic cell death modes. This review summarized the current status of research on the molecular mechanisms and targets through which quercetin-mediated non-apoptotic mode of cancer cell death, including autophagic cell death, senescence, mitotic catastrophe, ferroptosis, necroptosis, etc.

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Meriolin1 induces cell cycle arrest, apoptosis, autophagy and targeting the Akt/MAPKs pathways in human neuroblastoma SH-SY5Y cells

Cited by 6 publications

References 50 publications

Modulation of TLR/NF-κB/NLRP Signaling by Bioactive Phytocompounds: A Promising Strategy to Augment Cancer Chemotherapy and Immunotherapy

Modulation of TLR/NF-κB/NLRP Signaling by Bioactive Phytocompounds: A Promising Strategy to Augment Cancer Chemotherapy and Immunotherapy

A Novel Synthesis Method of Meriolin1

Targeting of non-apoptotic cancer cell death mechanisms by quercetin: Implications in cancer therapy

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