Update on management of keloid and hypertrophic scars: A systemic review

Elsaie, Mohamed L.

doi:10.1111/jocd.14310

Cited by 60 publications

(70 citation statements)

References 61 publications

(67 reference statements)

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“…At present, the treatment of scars at domestic and overseas mostly uses local drug sealing, skin transplantation, surgical resection, and skin grafting. 6 Some treatments are not very mature clinically, and the efficacy remains to be seen. In addition, most treatments take a long time and are accompanied by pain, are prone to recurrence and have many side effects, most of which are unsatisfactory.…”

Section: Introductionmentioning

confidence: 99%

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β‐Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts

Guo

Chen

et al. 2022

IUBMB Life

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Hypertrophic scar (HS) is a condition characterized by excessive synthesis and deposition of collagen. There are many clinical methods to alleviate HS, but most of them are accompanied by many complications. To investigate the effects of β‐Elemene, extracted from the ginger family plant Wenyujin, on human hypertrophic scar fibroblast (hHSFs). Cultured hHSFs and human normal fibroblasts, observed the effect of β‐Elemene on apoptosis, extracellular matrix, and endoplasmic reticulum stress (ERS) by western blot, Real Time‐Polymerase Chain Reaction (RT‐PCR), and flow cytometry. Based on our findings, it is clear that β‐Elemene could inhibit the expression of α‐smooth muscle actin (α‐SMA), collagen I, and fibronectin, reduced collagen deposition. Further studies had found that β‐Elemene could increase the expression of ERS‐related proteins CHOP and Calnexin in a dose‐dependent manner, thereby promoting the aggregation of cleaved‐caspase‐3 and inducing hHSFs to undergo poptosis. This process may depend on the regulation of P53. The results of our study indicates that β‐Elemene induced hHSFs to undergo apoptosis though ERS pathway in a P53‐dependent manner, which means that our research provided a new strategy for the development of drugs for the treatment of HS.

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Section: Introductionmentioning

confidence: 99%

“…At present, the treatment of scars at domestic and overseas mostly uses local drug sealing, skin transplantation, surgical resection, and skin grafting 6 . Some treatments are not very mature clinically, and the efficacy remains to be seen.…”

Section: Introductionmentioning

confidence: 99%

β‐Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts

Guo

Chen

et al. 2022

IUBMB Life

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“…It is an abnormal form characterized by continuous, localized inflammation in the wound region, which results in excessive collagen synthesis and an overstated accumulation of extracellular matrix components in these wounds. Examples of excessive wound healing are keloid and hypertrophic scars [17].…”

Section: Introductionmentioning

confidence: 99%

Angiogenin and Copper Crossing in Wound Healing

Cucci

Satriano

Marzo

et al. 2021

IJMS

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Angiogenesis plays a key role in the wound healing process, involving the migration, growth, and differentiation of endothelial cells. Angiogenesis is controlled by a strict balance of different factors, and among these, the angiogenin protein plays a relevant role. Angiogenin is a secreted protein member of the ribonuclease superfamily that is taken up by cells and translocated to the nucleus when the process of blood vessel formation has to be promoted. However, the chemical signaling that activates the protein, normally present in the plasma, and the transport pathways through which the protein enters the cell are still largely unclear. Copper is also an angiogenic factor that regulates angiogenin expression and participates in the activation of common signaling pathways. The interaction between angiogenin and copper could be a relevant mechanism in regulating the formation of new blood vessel pathways and paving the way to the development of new drugs for chronic non-healing wounds.

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“…8 A plethora of recent studies revealed that microneedling can provide significant improvements of acne scars, regardless of severity (mild-severe) at baseline, scar type (global, icepick, rolling, boxcar). [9][10][11] Ameloriation in skin by microneedling was related to promoting neocollagenesis as well as to modulation of gene expression in treated skin, inducing skin repair. 12 Vitamin C improves and promotes tissue repair and neocollagenesis.…”

Section: Discussionmentioning

confidence: 99%

Microneedling with topical vitamin C versus microneedling with topical insulin in the treatment of atrophic post‐acne scars: A split‐face study

Abbas

Elgamal

Zaky

et al. 2022

Dermatologic Therapy

Self Cite

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Post acne scars following sebaceous injury and abnormal wound healing during the course of acne is a prevalent and challenging to treat condition To evaluate microneedling by dermapen with topical vitamin C versus microneedling with topical insulin in treating atrophic post-acne scars. A split-face comparative study included 30 subjects with atrophic post-acne scars. Human insulin was topically applied to the left side of the face and on the right side, vitamin C serum was applied. Scars were assessed via the Acne Scar Assessment Scale (ASAS) and Scar quartile grading scale (SQGS). After 1 month of 4 treatments, a statistically significant mean improvement in ASAS value was reported on both split sides of the face (2.13 and 1.83) compared to baseline (3.03 and 2.93) (p = 0.005; p = 0.001 respectively). When compared to baseline, the mean ASAS value improved significantly with a slight more improvement on the vitamin c treated side. Topical insulin and vitamin c combined with microneedling, may both achieve comparable significant improvement for treating post acne scars. Insulin can be a promising novel anti-scarring therapy pending larger controlled studies to verify its efficacy.

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Update on management of keloid and hypertrophic scars: A systemic review

Cited by 60 publications

References 61 publications

β‐Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts

β‐Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts

Angiogenin and Copper Crossing in Wound Healing

Microneedling with topical vitamin C versus microneedling with topical insulin in the treatment of atrophic post‐acne scars: A split‐face study

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