Update on heart failure management and future directions

Choi, Hyeong‐Ah; Park, Myung-Soo; Youn, Jong-Chan

doi:10.3904/kjim.2018.428

Cited by 91 publications

(60 citation statements)

References 211 publications

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“…However, with reimbursement for the device and increasing awareness and education of HF patients and physicians, there was has been a steady increase in device therapy in patients with HF (Fig. 3A) [52]. Because of the improvements in the treatment of HF, an increasing number of patients are living with advanced-stage HF [53].…”

Section: Device Therapy and Heart Transplantationmentioning

confidence: 99%

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Current status of heart failure: global and Korea

Park

Choi

2020

Korean J Intern Med

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Heart failure (HF) is a condition in which the heart is unable to pump enough blood to meet the body's needs for blood and oxygen. Thus, HF is a grave disease with high morbidity and mortality. Because the prevalence of and exposure to the risk factors for HF increase with age, the prevalence of HF has been increasing in an aging society, including Korea. The vast advancement of medical and device therapy has improved the outcomes of HF, but significant residual risk still exists, and the benefit is confined to patients with reduced ejection fraction. Finding effective treatment for HF with preserved ejection fraction and identification of groups who benefit from drug and device therapy remain challenging. In this review, we illustrate the epidemiology, temporal trends, and current status of medical and device therapy, including heart transplantation, as well as emerging treatments for HF in Korea and worldwide.

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Section: Device Therapy and Heart Transplantationmentioning

confidence: 99%

“…(B) Heart transplantation. Adapted from Choi et al[52]. ICD, implantable cardioverter-defibrillator; CRT-P, cardiac resynchronization therapy without defibrillator; CRT-D, cardiac resynchronization therapy with defibrillator.…”

mentioning

confidence: 99%

Current status of heart failure: global and Korea

Park

Choi

2020

Korean J Intern Med

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“…Heart failure (HF) is the primary cause of cardiovascular mortality worldwide. The prevalence of HF is approximately 1.5% in Korea, with similar rates in other developed countries [1,2]. However, the incidence of HF has steadily increased over the decades, especially among aging populations.…”

Section: Introductionmentioning

confidence: 80%

Angiotensin receptor-neprilysin inhibitor for the treatment of heart failure: a review of recent evidence

Choi

Shin

2020

Korean J Intern Med

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Heart failure (HF) is a growing health concern in aging societies worldwide. Sacubitril/valsartan is changing the real-world treatment in the whole spectrum of HF. The beginning was the PARADIGM-HF trial published in 2014, which demonstrated the beneficial effects of inhibiting natriuretic peptide breakdown in combination with hindering the renin-angiotensin system in HF patients with a reduced ejection fraction. Subsequent large-scale randomized trials have evaluated angiotensin receptor-neprilysin inhibitor in HF patients with acute decompensation or with preserved ejection fraction. The post hoc analyses are being conducted as well. This review summarizes the recent evidence of sacubitril/ valsartan regarding patient-centered outcomes, based on randomized controlled trials and their associated studies.

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“…Thus the role of computable phenotype in real-time use is work in progress. As variety of rapid data is coming out in addition to data from electronic medical records [26]. To enhance machine learning and artificial intelligence capabilities, we must be able to aggregate medical records data in timely fashion [27].…”

Section: Discussionmentioning

confidence: 99%

Derivation and validation of a computable phenotype for acute decompensated heart failure in hospitalized patients

Kashyap

Sarvottam

Wilson

et al. 2020

BMC Med Inform Decis Mak

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Background: With higher adoption of electronic health records at health-care centers, electronic search algorithms (computable phenotype) for identifying acute decompensated heart failure (ADHF) among hospitalized patients can be an invaluable tool to enhance data abstraction accuracy and efficacy in order to improve clinical research accrual and patient centered outcomes. We aimed to derive and validate a computable phenotype for ADHF in hospitalized patients. Methods: We screened 256, 443 eligible (age > 18 years and with prior research authorization) individuals who were admitted to Mayo Clinic Hospital in Rochester, MN, from January 1, 2006, through December 31, 2014. Using a randomly selected derivation cohort of 938 patients, several iterations of a free-text electronic search were developed and refined. The computable phenotype was subsequently validated in an independent cohort 100 patients. The sensitivity and specificity of the computable phenotype were compared to the gold standard (expert review of charts) and International Classification of Diseases-9 (ICD-9) codes for Acute Heart Failure. Results: In the derivation cohort, the computable phenotype achieved a sensitivity of 97.5%, and specificity of 100%, whereas ICD-9 codes for Acute Heart Failure achieved a sensitivity of 47.5% and specificity of 96.7%. When all Heart Failure codes (ICD-9) were used, sensitivity and specificity were 97.5 and 86.6%, respectively. In the validation cohort, the sensitivity and specificity of the computable phenotype were 100 and 98.5%. The sensitivity and specificity for the ICD-9 codes (Acute Heart Failure) were 42 and 98.5%. Upon use of all Heart Failure codes (ICD-9), sensitivity and specificity were 96.8 and 91.3%. Conclusions: Our results suggest that using computable phenotype to ascertain ADHF from the clinical notes contained within the electronic medical record are feasible and reliable. Our computable phenotype outperformed ICD-9 codes for the detection of ADHF.

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Update on heart failure management and future directions

Cited by 91 publications

References 211 publications

Current status of heart failure: global and Korea

Current status of heart failure: global and Korea

Angiotensin receptor-neprilysin inhibitor for the treatment of heart failure: a review of recent evidence

Derivation and validation of a computable phenotype for acute decompensated heart failure in hospitalized patients

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