Current status of heart failure: global and Korea

Park, Jin Joo; Choi, Dong Ju

doi:10.3904/kjim.2020.120

Cited by 32 publications

(38 citation statements)

References 60 publications

(72 reference statements)

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“…4 It was estimated that the prevalence of heart failure worldwide was between 0.1% and 6.7%. 5 The determination of peripheral leukocytes, mainly neutrophils, and counting was a cheap and widely available method to assess the presence of any inflammation. Studies had shown that patients with heart failure had higher circulating levels of pro-inflammatory cytokines, including non-cellular and cellular components, compared with healthy people.…”

Section: Introductionmentioning

confidence: 99%

The Neutrophil-to-Albumin Ratio as a New Predictor of All-Cause Mortality in Patients with Heart Failure

Hu¹,

Wang²,

Xue³

et al. 2022

JIR

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Background: Neutrophils and albumin had been shown to be independent predictors of mortality from various diseases. Purpose of this study was to investigate the effect of neutrophil-to-albumin ratio (NPAR) as an independent predictor of mortality in heart failure (HF) patients. Methods: Data were extracted from Medical Information Mart for Intensive Care-III database. Primary outcome was 30-day mortality, secondary outcomes were in-hospital, 90-day, 365-day mortality, length of stay (LOS) in hospital. Cox proportional hazards regression model and receiver operating characteristic (ROC) curve analysis and Pearson correlation analysis were used. Results:The HR (95% CI) values of the mid-tertile and the upper tertile were 1.27 (1.01 to 1.59) and 2.29 (1.87 to 2.81) in 30-day mortality compared with the reference. The trend continued after adjusted for demographic and clinical variables. In the secondary outcomes were the same trends. The data of the Second Affiliated Hospital of Wenzhou Medical University showed the correlation coefficient between hospital LOS with NPAR. Conclusion: NPAR was an independent factor of mortality in HF patients, which was correlated with hospital LOS. Our results need to be verified by prospective studies.

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Section: Introductionmentioning

confidence: 99%

The Neutrophil-to-Albumin Ratio as a New Predictor of All-Cause Mortality in Patients with Heart Failure

Hu¹,

Wang²,

Xue³

et al. 2022

JIR

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“…Not all diabetic patients develop HF, and not all HF patients have diabetes [ 7 , 8 ]. Nonetheless, diabetes is an important risk factor for the development of HF.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology, Pathophysiology, Diagnosis and Treatment of Heart Failure in Diabetes

Park

2021

Diabetes Metab J

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The cardiovascular disease continuum begins with risk factors such as diabetes mellitus (DM), progresses to vasculopathy and myocardial dysfunction, and finally ends with cardiovascular death. Diabetes is associated with a 2- to 4-fold increased risk for heart failure (HF). Moreover, HF patients with DM have a worse prognosis than those without DM. Diabetes can cause myocardial ischemia via micro- and macrovasculopathy and can directly exert deleterious effects on the myocardium. Hyperglycemia, hyperinsulinemia, and insulin resistance can cause alterations in vascular homeostasis. Then, reduced nitric oxide and increased reactive oxygen species levels favor inflammation leading to atherothrombotic progression and myocardial dysfunction. The classification, diagnosis, and treatment of HF for a patient with and without DM remain the same. Until now, drugs targeting neurohumoral and metabolic pathways improved mortality and morbidity in HF with reduced ejection fraction (HFrEF). Therefore, all HFrEF patients should receive guideline-directed medical therapy. By contrast, drugs modulating neurohumoral activity did not improve survival in HF with preserved ejection fraction (HFpEF) patients. Trials investigating whether sodium-glucose cotransporter-2 inhibitors are effective in HFpEF are on-going. This review will summarize the epidemiology, pathophysiology, and treatment of HF in diabetes.

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“…A recent study of pooled data from European, American, and Asian populations with HF (with reduced ejection fraction) showed that the rate of cardiovascular death/hospitalization for HF is higher in Asia than in Western Europe and North America [12]. This has also been shown in Korean HF registries [13].…”

Section: Introductionmentioning

confidence: 90%

Is there sufficient evidence to justify changes in dietary habits in heart failure patients? A systematic review

García‐García¹,

Álvarez‐Sala‐Walther²,

Lee

et al. 2022

Korean J Intern Med

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The incidence and prevalence of heart failure (HF) is increasing worldwide, leading to high morbidity and mortality. The global management of HF involves lifestyle changes in addition to pharmacological treatments. Changes include exercise and dietary recommendations, mainly salt and fluid restriction, but without any clear evidence. We conducted a systematic review to analyse the degree of evidence for these dietary recommendations in HF. Only randomized controlled trials (RCT), and observational studies in humans were selected. Studies were considered eligible if they included participants with HF and sodium and/or fluid restriction. Publications in languages other than English or Spanish were excluded. We included 15 studies related to sodium or fluid restriction. Nine RCT and six observational studies showed some improvements in symptoms and quality of life and a degree of reduction in new hospitalizations, but the results are based on limited population groups, applying different methodologies, and with different restriction goals. We found a lack of clear evidence of the benefits of sodium/fluid restriction in chronic HF. The evidence is limited to few studies with conflicting results. Randomized clinical trials are needed to fill this gap in our knowledge.

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Current status of heart failure: global and Korea

Cited by 32 publications

References 60 publications

The Neutrophil-to-Albumin Ratio as a New Predictor of All-Cause Mortality in Patients with Heart Failure

The Neutrophil-to-Albumin Ratio as a New Predictor of All-Cause Mortality in Patients with Heart Failure

Epidemiology, Pathophysiology, Diagnosis and Treatment of Heart Failure in Diabetes

Is there sufficient evidence to justify changes in dietary habits in heart failure patients? A systematic review

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