Update on F-18-fluoro-deoxy-glucose-PET/computed tomography in nonsmall cell lung cancer

Usmanij, Edwin A.; Bussink, Johan; Oyen, Wim J.G.

doi:10.1097/mcp.0000000000000182

Cited by 21 publications

(13 citation statements)

References 77 publications

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“…Moreover, complications of these metastases often include GI perforation, obstruction, and hemorrhage, whereas complications such as pneumoperitoneum and intussusception are relatively uncommon [5,10]. Total-body imaging used during lung cancer staging may increase the discovery of GI masses [11]. However, adding to the diagnostic challenge, imaging studies, such as a CT scan of the abdomen, generally have a low sensitivity for detecting GI metastases [12].…”

Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Poorly Differentiated Lung Carcinoma with Duodenal Metastasis and Literature Review

Ahmed

Nasir

Donna

et al. 2020

Case Rep Gastroenterol

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Lung cancer is a common malignancy which is frequently found to metastasize to distant sites including bone, liver, and adrenal glands. There are rare reports of metastases to the gastrointestinal (GI) tract, with the duodenum being the most uncommon. We present a rare case of a poorly differentiated lung carcinoma metastasizing to the duodenum. This case enhances the medical literature as it provides additional distinct features to the clinical and histological presentation of metastatic lung carcinoma to the GI tract. A 61-year-old male with a history of poorly differentiated lung carcinoma presented with worsening dizziness, fatigue, and early satiety. He had extensive workup done in the past for hemoptysis including a computerized tomography scan of the chest which showed a new lobulated, apical lesion and hilar Case Ahmed et al.: Poorly Differentiated Lung Carcinoma Metastasis to the Duodenum 187lymphadenopathy. He ultimately had a transthoracic fine-needle aspiration (FNA) of the mass and was later diagnosed with poorly differentiated lung carcinoma. On examination, the patient was noted to be pale, tachycardic, and hypotensive. The patient was noted to have an acute drop in his hemoglobin requiring fluid resuscitation, multiple blood transfusions, and evaluation with an esophagogastroduodenoscopy. He was found to have an oozing ulcer in the third portion of the duodenum whose biopsies showed poorly differentiated carcinoma with areas of neuroendocrine differentiation, similar to his lung biopsy results, which was consistent with metastatic lung carcinoma.

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Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Poorly Differentiated Lung Carcinoma with Duodenal Metastasis and Literature Review

Ahmed

Nasir

Donna

et al. 2020

Case Rep Gastroenterol

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“…In this study, early metabolic changes were measured using the difference in the total lesion glycolysis (TLG) between the pre-treatment FDG PET scan and the second scan at the end of the second week of therapy. Here, changes in TLG during the first two weeks of therapy were reported to be prognostic for response to concomitant radiochemotherapy in NSCLC (Usmanij et al 2013). Furthermore, pre-treatment TLG was observed to be correlated with progression-free survival (PFS) in this patient group (Usmanij et al 2013).…”

Section: Use Of Fdg In Radiation Oncologymentioning

confidence: 93%

“…Here, changes in TLG during the first two weeks of therapy were reported to be prognostic for response to concomitant radiochemotherapy in NSCLC (Usmanij et al 2013). Furthermore, pre-treatment TLG was observed to be correlated with progression-free survival (PFS) in this patient group (Usmanij et al 2013). A similar study published by Van Elmpt et al (2012) investigated response assessment in n = 34 NSCLC patients using changes in mean SUV in the target volume comparing pre-treatment FDG PET/CT scans to scans acquired after two weeks of radiochemotherapy.…”

Section: Use Of Fdg In Radiation Oncologymentioning

confidence: 93%

“…In addition, a number of different studies have shown the value of FDG PET/CT for early response monitoring of (chemo-)radiotherapy in several tumour sites (Usmanij et al 2013;Cuenca et al 2013;Van Elmpt et al 2012;Hatt et al 2013). A recent study in oesophageal cancer investigated the potential of early response assessment via FDG PET/CT after 2 weeks of radiochemotherapy (20Gy plus 2 cycles of chemotherapy).…”

Section: Use Of Fdg In Radiation Oncologymentioning

confidence: 97%

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FDG and Beyond

Ruysscher

Haustermans

Thorwarth³

2016

Molecular Radio-Oncology

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“…PET/ CT has become a major oncologic imaging modality for diagnosis, prognostication, therapy monitoring, and radiation therapy planning (1). Respiratory motion has significant negative effects on image quality, on the accuracy with which PET quantifies lesion activity, on fusion accuracy, and on delineation of lesion volume (2).…”

mentioning

confidence: 99%

Reduction of Respiratory Motion During PET/CT by Pulsatile-Flow Ventilation: A First Clinical Evaluation

et al. 2015

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Respiratory motion negatively affects PET/CT image quality and quantitation. A novel Pulsatile-Flow Ventilation (PFV) system reducing respiratory motion was applied in spontaneously breathing patients to induce sustained apnea during PET/CT. Methods: Four patients (aged 65 ± 14 y) underwent PET/CT for pulmonary nodule staging (mean, 11 ± 7 mm; range, 5-18 mm) at 63 ± 3 min after 18 F-FDG injection and then at 47 ± 7 min afterward, during PFV-induced apnea (with imaging lasting $8.5 min). Anterior-posterior thoracic amplitude, SUV max , and SUV peak (SUV mean in a 1-cm-diameter sphere) were compared. Results: PFV PET/CT reduced thoracic amplitude (80%), increased mean lesion SUV max (29%) and SUV peak (11%), decreased lung background SUV peak (25%), improved lesion detectability, and increased SUV peak lesion-to-background ratio (54%). On linear regressions, SUV max and SUV peak significantly improved (by 35% and 23%, respectively; P # 0.02). Conclusion: PFV-induced apnea reduces thoracic organ motion and increases lesion SUV, detectability, and delineation, thus potentially affecting patient management by improving diagnosis, prognostication, monitoring, and external-radiation therapy planning.

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Update on F-18-fluoro-deoxy-glucose-PET/computed tomography in nonsmall cell lung cancer

Abstract: The role of PET is described for diagnosis, staging and response assessment.

Cited by 21 publications

References 77 publications

A Rare Presentation of Poorly Differentiated Lung Carcinoma with Duodenal Metastasis and Literature Review

A Rare Presentation of Poorly Differentiated Lung Carcinoma with Duodenal Metastasis and Literature Review

FDG and Beyond

Reduction of Respiratory Motion During PET/CT by Pulsatile-Flow Ventilation: A First Clinical Evaluation

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