Update on Actinomucor elegans , a mucormycete infrequently detected in human specimens: how combined microbiological tools contribute efficiently to a more accurate medical care

Dorin, Joséphine; d’Aveni, Maud; Debourgogne, Anne; Cuenin, Michael F.; Guillaso, M.; Rivier, Alexandre; Gallet, P.; Lecoanet, Guillaume; Machouart, Marie

doi:10.1016/j.ijmm.2017.10.010

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…Actinomucor elegans belongs to the genus Actinomucor in the order Mucorales. So far, only 5 cases of infection with Actinomucor elegans in humans have been described in adults [2,10,11]. Two patients (1 immunocompetent, 1 recipient of an allogeneic stem cell transplantation for lymphoma) were described with sinusitis and were cured with debridement, irrigation and antifungal treatment [2,12].…”

Section: Discussionmentioning

confidence: 99%

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Invasive mucormycosis during treatment for acute lymphoblastic leukaemia—successful management of two life-threatening diseases

Trobisch

Marterer

Gorkiewicz

et al. 2019

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A 5-year-old patient treated for acute lymphoblastic leukaemia (ALL) developed proven pulmonary invasive fungal disease (IFD) due to Actinomucor elegans. While completing ALL treatment according to AIEOP ALL protocol 2009 for further 15 months, antifungal treatment with liposomal amphotericin B and intermittent additional posaconazole was continued until immune reconstitution 7 months after the end of ALL treatment. Repeated imaging guided treatment decisions. Twenty-six and 19 months after the end of ALL treatment and antifungal treatment, respectively, the patient is still in the first complete remission and shows no signs of active invasive fungal disease (IFD).

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Section: Discussionmentioning

confidence: 99%

“…Invasive mould diseases remain an important cause of death in immunocompromised patients [1,2]. While invasive diseases with Aspergillus sp.…”

Section: Introductionmentioning

confidence: 99%

Invasive mucormycosis during treatment for acute lymphoblastic leukaemia—successful management of two life-threatening diseases

Trobisch

Marterer

Gorkiewicz

et al. 2019

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“…7 Disseminated infection was diagnosed in two cases following a trauma during combat in Iran 8 and in a diabetic patient with refractory aplasic anemia. 9 Out of five patients, two were cured with surgery debridement and amphotericin B administration, 5,6 two died despite debridement and broad spectrum antifungal, 8,9 and one was lost to follow-up. 7…”

Section: Introductionmentioning

confidence: 99%

Emerging mould infections: Get prepared to meet unexpected fungi in your patient

et al. 2019

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Invasive fungal diseases are increasing issues in modern medicine, where the human immunodeficiency virus (HIV) pandemic and the wider use of immunosuppressive drugs generate an ever-growing number of immunocompromised patients with an increased susceptibility to uncommon fungal pathogens. In the past decade, new species have been reported as being responsible for disseminated and invasive fungal diseases in humans. Among them, the following genera are rare but seem emerging issues: Scopulariopsis, Hormographiella, Emergomyces, Westerdykella, Trametes, Actinomucor, Saksenaea, Apophysomyces, and Rhytidhysteron. Delay in diagnosis, which is often the case in these infections, jeopardizes patients’ prognosis and leads to increased mortality. Here we summarize the clinical and biological presentation and the key features to identify these emerging pathogens and we discuss the available antifungal classes to treat them. We focused on Pubmed to recover extensively reported human invasive cases and articles regarding the nine previously cited fungal organisms. Information concerning patient background, macroscopic and microscopic description and pictures of these fungal organisms, histological features in tissues, findings with commonly used antigen tests in practice, and hints on potential efficient antifungal classes were gathered. This review's purpose is to help clinical microbiologists and physicians to suspect, identify, diagnose, and treat newly encountered fungi in hospital settings.

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“…Other interesting and unusual ecological findings with respect to Mucoromycota that require further studies are as follows: pathogenic nature of Syncephalastrum sp. in gardens of leaf-cutting ants (Barcoto et al 2017); Mucor racemosus as part of the lichen-associated mycobiota (Tripathi et al 2014;Lagarde et al 2018); and frequent and occasional human mucormycosis-causing agents, Apophysomyces variabilis (Prakash et al 2016) and Actinomucor elegans (Dorin et al 2017), respectively, which have been observed to be a part of the green turtle nest mycobiota, where both the fungal species can be considered novel pathogens for the turtles (Candan 2018). Mucor abundans, Umbelopsis angularis, U. isabelina, U. ramanniana and a new putative species of Apophysomyces have been found to be associated with the millipede fungivore Brachycybe lecontii (Macias et al 2019).…”

Section: Orpinomyces Joyonii Mt085733mentioning

confidence: 99%

Early-diverging fungal phyla: taxonomy, species concept, ecology, distribution, anthropogenic impact, and novel phylogenetic proposals

et al. 2021

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The increasing number of new fungal species described from all over the world along with the use of genetics to define taxa, has dramatically changed the classification system of early-diverging fungi over the past several decades. The number of phyla established for non-Dikarya fungi has increased from 2 to 17. However, to date, both the classification and phylogeny of the basal fungi are still unresolved. In this article, we review the recent taxonomy of the basal fungi and re-evaluate the relationships among early-diverging lineages of fungal phyla. We also provide information on the ecology and distribution in Mucoromycota and highlight the impact of chytrids on amphibian populations. Species concepts in Chytridiomycota, Aphelidiomycota, Rozellomycota, Neocallimastigomycota are discussed in this paper. To preserve the current application of the genus Nephridiophaga (Chytridiomycota: Nephridiophagales), a new type species, Nephridiophaga blattellae, is proposed.

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Update on Actinomucor elegans , a mucormycete infrequently detected in human specimens: how combined microbiological tools contribute efficiently to a more accurate medical care

Cited by 5 publications

References 18 publications

Invasive mucormycosis during treatment for acute lymphoblastic leukaemia—successful management of two life-threatening diseases

Invasive mucormycosis during treatment for acute lymphoblastic leukaemia—successful management of two life-threatening diseases

Emerging mould infections: Get prepared to meet unexpected fungi in your patient

Early-diverging fungal phyla: taxonomy, species concept, ecology, distribution, anthropogenic impact, and novel phylogenetic proposals

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