Invasive mucormycosis during treatment for acute lymphoblastic leukaemia—successful management of two life-threatening diseases

Trobisch, Andreas; Marterer, Robert; Gorkiewicz, Gregor; Flaschberger, Stefan; Lackner, Herwig; Seidel, Markus G.; Sperl, Daniela; Karastaneva, Anna; Kohlmaier, Benno; Egger, Matthias; Urban, Christian; Benesch, Martin; Strenger, Volker

doi:10.1007/s00520-019-04962-3

Cited by 8 publications

(9 citation statements)

References 26 publications

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“…A recent retrospective study pointed out that the combination of liposomal AmB together with posaconazole produced a significant synergistic effect for ensuring short-term survival in patients with hematologic malignancy and was more effective than monotherapy [ 435 ]. Similar results were seen in a patient with acute lymphoblastic leukemia, although the drug of choice in this case was AmB lipid complex [ 436 ]. This evidence shows the potential synergistic interaction that can be obtained with AmB in lipid formulation.…”

Section: Clinical Use Of Polyenessupporting

confidence: 82%

Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications

et al. 2022

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This review examined a collection of studies regarding the molecular properties of some polyene antibiotic molecules as well as their properties in solution and in particular environmental conditions. We also looked into the proposed mechanism of action of polyenes, where membrane properties play a crucial role. Given the interest in polyene antibiotics as therapeutic agents, we looked into alternative ways of reducing their collateral toxicity, including semi-synthesis of derivatives and new formulations. We follow with studies on the role of membrane structure and, finally, recent developments regarding the most important clinical applications of these compounds.

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Section: Clinical Use Of Polyenessupporting

confidence: 82%

Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications

et al. 2022

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“…This is the first reported case of rhino-orbito-cerebral mucormycosis due to Actinomucor elegans in a pediatric patient with leukemia. It was previously reported in a 5-year-old patient with acute lymphoblastic leukemia, however, in this case an invasive pulmonary mucormycosis was developed [20].…”

Section: Discussionmentioning

confidence: 50%

Rhino-orbito-cerebral mucormycosis in an acute lymphoblastic leukemia pediatric patient. Case report and review of literature

et al. 2022

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Mucormycosis is a disease caused by opportunistic fungi of the order Mucorales that generally affects immunocompromised patients or those with underlying disease. It has a high mortality rate and is the third most common invasive fungal infection. The following is a case report of a 12-year-old pediatric patient diagnosed with B-cell acute lymphoblastic leukemia, who presented an aggressive infectious disease two months after beginning chemotherapy, which began in the right frontal and maxillary sinuses, with subsequent progression and extension, progressively SUMMARY deteriorating the patient's clinical status. Culture and biopsy of the affected areas were performed, confirming by histopathology and isolation a rhino-orbito-cerebral mucormycosis due to Actinomucor elegans. The patient was treated with specific antifungal therapy as an inpatient and left the service after obtaining negative cultures, continuing with outpatient antifungal treatment.

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“…One of the most important characteristics of Mucorales is their marked vascular tropism, which facilitates hematogenous dissemination and vascular thrombosis, causing lesions with extensive tissue necrosis 7 . This scenario hinders the arrival of leukocytes to the site of infection and the penetration of drugs into the tissues, complicating treatment 8 .…”

Section: Discussionmentioning

confidence: 99%

Disseminated mucormycosis in a child with acute lymphoblastic leukemia: a case report and autopsy findings

Teco-Cortés¹,

Arrecillas-Zamora²

2023

BMHIM

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Background: Mucormycosis is a rare infection caused by ubiquitous fungi of the Mucorales order that mainly affects immunocompromised patients. These fungi have an important tropism for blood vessels that allows them to spread rapidly and cause thromboembolic events. Case report: We present a case of an 8-year-old male patient diagnosed with acute lymphoblastic leukemia treated with chemotherapy. He presented icteric syndrome, hepato-splenomegaly, and data of intestinal obstruction. Although he underwent intestinal resection, he did not improve and died. The autopsy identified disseminated mucormycosis involving the brain, lungs, esophagus, small intestine, colon, and pancreas. Conclusions: Hematological neoplastic diseases and their treatment are important risk factors for developing infections by opportunistic microorganisms such as mucormycosis. Early diagnosis and adequate treatment are essential due to their intrinsic difficulty and the high mortality rate of these cases.

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Invasive mucormycosis during treatment for acute lymphoblastic leukaemia—successful management of two life-threatening diseases

Cited by 8 publications

References 26 publications

Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications

Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications

Rhino-orbito-cerebral mucormycosis in an acute lymphoblastic leukemia pediatric patient. Case report and review of literature

Disseminated mucormycosis in a child with acute lymphoblastic leukemia: a case report and autopsy findings

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