Update of the European consensus on sarcopenia: what has changed in diagnosis and prevalence in peritoneal dialysis?

Silva, Maryanne Zilli Canedo; Vogt, Barbara; Reis, Nayrana Soares do Carmo; Caramori, Jacqueline Costa Teixeira

doi:10.1038/s41430-019-0468-z

Cited by 23 publications

(20 citation statements)

References 9 publications

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“…In contrast to our data in liver cirrhosis, in patients with peritoneal dialysis the definition from 2010 identified less patients as sarcopenic compared to the 2019 definition (4% versus 10%) [23]. In this study, however, muscle mass was assessed using dual energy x-ray absorptiometry (DEXA), which might also be a reason for the discrepant results compared to liver cirrhosis [23]. Large differences in the prevalence of sarcopenia between CT scan (70.3%) and DEXA (38.7%) were also found in patients with chronic liver disease [24].…”

Section: Discussioncontrasting

confidence: 99%

“…A couple of studies already compared the 2010 and the 2019 criteria in elderly and in in different disease cohorts. In contrast to our data in liver cirrhosis, in patients with peritoneal dialysis the definition from 2010 identified less patients as sarcopenic compared to the 2019 definition (4% versus 10%) [23]. In this study, however, muscle mass was assessed using dual energy x-ray absorptiometry (DEXA), which might also be a reason for the discrepant results compared to liver cirrhosis [23].…”

Section: Discussioncontrasting

confidence: 86%

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Sarcopenia and Liver Cirrhosis—Comparison of the European Working Group on Sarcopenia Criteria 2010 and 2019

et al. 2020

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The European Working group on Sarcopenia in Older People recently updated the diagnostic criteria for sarcopenia. It is yet unclear how these modified criteria influence the rate of diagnosis in high risk populations, such as liver cirrhosis. We therefore assessed if the new diagnostic criteria for sarcopenia impacts on sarcopenia prevalence in liver cirrhosis. Within two years 114 cirrhotic patients were prospectively enrolled in the study. Sarcopenia was determined by muscle strength (handgrip strength), muscle mass (lumbal muscle index) and muscle performance (gait speed). Using the 2019 definition, the rate of pre-sarcopenia was significantly lower (30.7% versus 3.5%) due to the different starting points (2010 muscle mass, 2019 muscle strength) and cut-off values (muscle strength). The change in diagnostic criteria for sarcopenia drastically influences the rate of pre-sarcopenia diagnosis in cirrhotics. To evaluate, which diagnostic criteria should be chosen to diagnose sarcopenia in liver cirrhosis patients, prospective studies are needed.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 86%

Sarcopenia and Liver Cirrhosis—Comparison of the European Working Group on Sarcopenia Criteria 2010 and 2019

et al. 2020

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“…The prevalence of sarcopenia in chronic kidney disease (CKD) patients varies widely, ranging from 4.0% to 13.7% depending on the CKD stage, kidney replacement therapy (KRT), and the consensus version [1][2][3]. This number is even higher in CKD patients aged 60 years and above [3].…”

Section: Introductionmentioning

confidence: 99%

Age, diabetes mellitus, and dialysis modality are associated with risk of poor muscle strength and physical function in hemodialysis and peritoneal dialysis patients

Silva

Antônio

Reis

et al. 2021

Kidney Res Clin Pract

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Background: Due to the poor outcomes associated with the impairment of physical function and muscle strength in patients on maintenance dialysis, it is important to understand the factors that may influence physical function and muscle strength. The aim of this study was to explore the factors associated with physical function in hemodialysis and peritoneal dialysis patients. Methods: Patients with chronic kidney disease on dialysis for at least 3 months, aged 18 years old or above, were enrolled. Physical function was assessed by handgrip strength, gait and sit-to-stand tests, and the Short Physical Performance Battery (SPPB). Clinical and laboratory data were collected to verify the association with physical function parameters through binary logistic regression. Results: One-hundred ninety patients on maintenance dialysis were included; 140 patients (73.7%) on hemodialysis and 50 (26.3%) on peritoneal dialysis. The mean age was 57.3 ± 14.9 years, 109 (57.4%) were male, and 87 (45.8%) were older than 60 years. The median SPPB was 8.0 points (6.0-10.0 points) and the mean ± standard deviation of handgrip strength was 24.7 ± 12.2 kg. Binary logistic regression showed that age, type of renal replacement therapy, diabetes mellitus, and serum creatinine were significantly associated with both higher 4-meter gait test times and lower SPPB scores. Only age and diabetes mellitus were associated with higher sit-to-stand test times, while age and ferritin were associated with lower handgrip strength. Conclusion: Age, diabetes mellitus, serum creatinine, and hemodialysis modality are factors related to physical function in dialysis patients.

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“…This was a secondary analysis of data from a study previously published (14), which enrolled patients aged 18 years or above, with CKD on PD (for at least 3 months) at the Dialysis Unit from the Clinics Hospital of Botucatu Medical School (Botucatu, Brazil). The protocol was approved by the Ethics and Research Committee (CAAE 61634816.4.0000.5411), and the participants gave written informed consent.…”

Section: Methodsmentioning

confidence: 99%

Association of Phase Angle, but Not Inflammation and Overhydration, With Physical Function in Peritoneal Dialysis Patients

Silva

Vogt

et al. 2021

Front. Nutr.

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Introduction: Muscle mass depletion, overhydration, and inflammatory state have been related to impaired physical function in chronic kidney disease patients. The relationship between bioelectrical impedance analysis (BIA) parameters, such as hydration status and phase angle (PhA), with physical function in peritoneal dialysis (PD), is still not well-established. Therefore, the objective was to evaluate the association of BIA parameters (overhydration index and PhA) and inflammatory markers with physical function in patients on PD.Methods: The present cross-sectional study enrolled PD patients. Multifrequency BIA was performed to obtain overhydration index and PhA. The Short Physical Performance Battery (SPPB) test battery was applied to assess physical function. The time to complete the 4-m gait test and sit-to-stand test was also considered for physical function assessment. The inflammatory markers tumor necrosis factor-alpha and C-reactive protein levels were determined. Multiple linear regression models were performed, with the physical function variables as dependent variables, adjusted for age, diabetes, and sex.Results: Forty-nine PD patients were enrolled, 53.1% (n = 26) women; mean age, 55.5 ± 16.3 years. There were significant correlations between PhA and SPPB (r = 0.550, p < 0.001), time of 4-m gait test (r = −0.613, p < 0.001) and sit-to-stand test and (r = −0.547, p < 0.001). Overhydration index was significantly correlated with SPPB, 4-m gait test (r = 0.339, p = 0.017), and sit-to-stand test (r = 0.335, p = 0.019). Inflammatory markers were not significantly correlated with physical function parameters. In the multiple linear regression analysis, PhA was associated with physical function parameters, even after adjustments. Overhydration index was associated with all physical function tests only in the models with no adjustments.Conclusion: PhA was independently associated with physical function in PD patients. Inflammatory markers and overhydration index were not associated with physical function.

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Update of the European consensus on sarcopenia: what has changed in diagnosis and prevalence in peritoneal dialysis?

Cited by 23 publications

References 9 publications

Sarcopenia and Liver Cirrhosis—Comparison of the European Working Group on Sarcopenia Criteria 2010 and 2019

Sarcopenia and Liver Cirrhosis—Comparison of the European Working Group on Sarcopenia Criteria 2010 and 2019

Age, diabetes mellitus, and dialysis modality are associated with risk of poor muscle strength and physical function in hemodialysis and peritoneal dialysis patients

Association of Phase Angle, but Not Inflammation and Overhydration, With Physical Function in Peritoneal Dialysis Patients

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