Background: Due to the poor outcomes associated with the impairment of physical function and muscle strength in patients on maintenance dialysis, it is important to understand the factors that may influence physical function and muscle strength. The aim of this study was to explore the factors associated with physical function in hemodialysis and peritoneal dialysis patients. Methods: Patients with chronic kidney disease on dialysis for at least 3 months, aged 18 years old or above, were enrolled. Physical function was assessed by handgrip strength, gait and sit-to-stand tests, and the Short Physical Performance Battery (SPPB). Clinical and laboratory data were collected to verify the association with physical function parameters through binary logistic regression. Results: One-hundred ninety patients on maintenance dialysis were included; 140 patients (73.7%) on hemodialysis and 50 (26.3%) on peritoneal dialysis. The mean age was 57.3 ± 14.9 years, 109 (57.4%) were male, and 87 (45.8%) were older than 60 years. The median SPPB was 8.0 points (6.0-10.0 points) and the mean ± standard deviation of handgrip strength was 24.7 ± 12.2 kg. Binary logistic regression showed that age, type of renal replacement therapy, diabetes mellitus, and serum creatinine were significantly associated with both higher 4-meter gait test times and lower SPPB scores. Only age and diabetes mellitus were associated with higher sit-to-stand test times, while age and ferritin were associated with lower handgrip strength. Conclusion: Age, diabetes mellitus, serum creatinine, and hemodialysis modality are factors related to physical function in dialysis patients.
Introduction and Aims:The evaluation of body composition in hemodialysis patients is of paramount importance since studies have demonstrated the association of protein energy wasting with an increased risk of morbidity and mortality in this population. It is important to identify a technique for assessing body composition that is simple, non-invasive, cost-effective and could be routinely used in clinical setting. This study aimed to evaluate single and multifrequency bioelectrical impedance analysis (BIA) with dual-energy X-ray absorptiometry (DXA) as a reference method, for the assessment of body fat and lean mass in patients on maintenance hemodialysis. Methods: This observational study included prevalent maintenance hemodialysis patients. Body fat (BF) and lean mass (LM) assessment were performed by DXA. Single and multifrequency BIA were used to assess BF and free fat mass (FFM) after a hemodialysis session. Bland & Altman concordance method was used to establish the concordance intervals between BIA and DXA. Results: Forty-one patients were included, mean age 59.8 ± 16.2 years, 51.2% were
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