Update of Immune Events in the Murine Contact Hypersensitivity Model: Toward the Understanding of Allergic Contact Dermatitis

Honda, Tetsuya; Egawa, Gyohei; Grabbe, Stephan; Kabashima, Kenji

doi:10.1038/jid.2012.284

Cited by 320 publications

(383 citation statements)

References 127 publications

(131 reference statements)

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“…Previous in vivo and in vitro studies demonstrated that haptens activate skin cells and induce the production of several cytokines including IL-1b that stimulates the migration of skin dendritic cells to the lymph nodes and has a key role in contact dermatitis [27]. Hapten-induced effects mediated by innate immune systems are essential for the activation of cutaneous antigen-presenting cells [28]. Indeed, the innate immunity response is a prerequisite for the activation of the ACD immune response [29].…”

Section: Discussionmentioning

confidence: 99%

Accumulation of metal-specific T cells in inflamed skin in a novel murine model of Chromium-induced allergic contact dermatitis

Shigematsu¹,

Kumagai²,

Kobayashi³

et al. 2014

Journal of Oral and Maxillofacial Surgery

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Chromium (Cr) causes delayed-type hypersensitivity reactions possibly mediated by accumulating T cells into allergic inflamed skin, which are called irritants or allergic contact dermatitis. However, accumulating T cells during development of metal allergy are poorly characterized because a suitable animal model is not available. This study aimed to elucidate the skewing of T-cell receptor (TCR) repertoire and cytokine profiles in accumulated T cells in inflamed skin during elucidation of Cr allergy. A novel model of Cr allergy was induced by two sensitizations of Cr plus lipopolysaccharide solution into mouse groin followed by single Cr challenge into the footpad. TCR repertoires and nucleotide sequences of complementary determining region 3 were assessed in accumulated T cells from inflamed skin. Cytokine expression profiles and T-cell phenotypes were determined by qPCR. CD3+CD4+ T cells accumulated in allergic footpads and produced increased T helper 1 (Th1) type cytokines, Fas, and Fas ligand in the footpads after challenge, suggesting CD4+ Th1 cells locally expanded in response to Cr. Accumulated T cells included natural killer (NK) T cells and Cr-specific T cells with VA11-1/VB14-1 usage, suggesting metal-specific T cells driven by invariant NKT cells might contribute to the pathogenesis of Cr allergy.

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Section: Discussionmentioning

confidence: 99%

Accumulation of metal-specific T cells in inflamed skin in a novel murine model of Chromium-induced allergic contact dermatitis

Shigematsu¹,

Kumagai²,

Kobayashi³

et al. 2014

Journal of Oral and Maxillofacial Surgery

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“…We first examined the effect of RvE1 in the sensitization phase of CHS because dermal DC migration to dLNs is an essential step for sensitization (Honda et al, 2013). WT mice treated with RvE1 exhibited a significantly reduced number of CD44 + CD62L + central memory T cells and CD44 + CD62L  effector memory T cells in dLNs after 0.5% 2,4-dinitrofluorobenzene (DNFB) application (Fig.…”

Section: Rve1 Inhibits DC Migration From Skin To Dlnsmentioning

confidence: 99%

“…In this study, we investigated the effects and underlying mechanisms of RvE1 on DC motility using a CHS model, which is a prototype of delayed-type hypersensitivity in the skin mediated by IFN- (Mori et al, 2008;Honda et al, 2013). RvE1 inhibited cutaneous DC migration into the dLNs and suppressed antigen-specific T cell induction in the sensitization phase.…”

mentioning

confidence: 99%

“…In acquired immunity such as contact hypersensitivity (CHS), upon uptake of foreign antigens, DCs migrate to the draining LNs (dLNs) via lymphatic vessels to establish sensitization by inducing the antigen-specific T cell differentiation (Honda et al, 2013). In elicitation, DC migration to form DC-T cell clustering is required for efficient antigen presentation in situ (Natsuaki et al, 2014).…”

mentioning

confidence: 99%

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Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses

Honda

Sawada

Kobayashi

et al. 2016

Journal of Dermatological Science

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Resolvin E1 (RvE1) is a lipid mediator derived from 3 polyunsaturated fatty acids that exerts potent antiinflammatory roles in several murine models. The antiinflammatory mechanism of RvE1 in acquired immune responses has been attributed to attenuation of cytokine production by dendritic cells (DCs). In this study, we newly investigated the effect of RvE1 on DC motility using two-photon microscopy in a contact hypersensitivity (CHS) model and found that RvE1 impaired DC motility in the skin. In addition, RvE1 attenuated T cell priming in the draining lymph nodes and effector T cell activation in the skin, which led to the reduced skin inflammation in CHS. In contrast, leukotriene B4 (LTB4) induced actin filament reorganization in DCs and increased DC motility by activating Cdc42 and Rac1 via BLT1, which was abrogated by RvE1. Collectively, our results suggest that RvE1 attenuates cutaneous acquired immune responses by inhibiting cutaneous DC motility, possibly through LTB4-BLT1 signaling blockade.

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“…ey dominate in the skin during the early phase of contact dermatitis [83]. 2 cells play a central role in allergic disorders such as AD by regulating both acute-and late-phase allergic reactions, mediated by immunoglobulin E and eosinophils, re-spectively.…”

Section: T Cells T Cells In Their Naive State Rst Encounter Apcs In Smentioning

confidence: 99%

Novel insights into the role of immune cells in skin and inducible skin-associated lymphoid tissue (iSALT)

Ono¹,

Kabashima²

2015

Allergo J

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Summarye skin is equipped with serial barriers that provide rapid and e cient protection against external intruders. Beneath the epidermal physical barriers of the stratum corneum and the tight junctions, the integrated immune systems in both the epidermis and the dermis act in a coordinated manner to protect the host.is "immunological" barrier is composed of various cells, including skin-resident cells, such as keratinocytes, dendritic cells, tissue-resident macrophages, resident memory T cells, mast cells, and innate lymphoid cells. Additionally, in ltrating memory T cells, monocytes, neutrophils, basophils, and eosinophils are recruited in support of the host immunity.In addition to discussing the role of each of these cellular populations, we describe the concept of skin associated lymphoid tissue (SALT), which reminds us that the skin is an important component of the lymphatic system. We further describe the newly discovered phenomenon of multiple cell gathering under skin in ammation, which can be referred to as inducible SALT (iSALT). iSALT contributes to our understanding of SALT by highlighting the importance of direct cell-cell interaction in skin immunity.Cite this as Ono S, Kabashima K. Novel insights into the role of immune cells in skin and inducible skin-associated lymphoid tissue (iSALT). Allergo J Int 2015;24:170-9

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Update of Immune Events in the Murine Contact Hypersensitivity Model: Toward the Understanding of Allergic Contact Dermatitis

Cited by 320 publications

References 127 publications

Accumulation of metal-specific T cells in inflamed skin in a novel murine model of Chromium-induced allergic contact dermatitis

Accumulation of metal-specific T cells in inflamed skin in a novel murine model of Chromium-induced allergic contact dermatitis

Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses

Novel insights into the role of immune cells in skin and inducible skin-associated lymphoid tissue (iSALT)

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