2020
DOI: 10.1016/j.molimm.2020.01.019
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Up-regulation of miR-326 regulates pro-inflammatory cytokines targeting TLR-4 in buffalo granulosa cells

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Cited by 8 publications
(6 citation statements)
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“…PRRs comprise TLRs, RIG-I-like receptors (RLRs), and NOD-like receptors (NLRs). TLRs activate viral responses by recognizing pathogenic microorganisms such as viruses, bacteria, and mycoplasmas to release inflammatory cytokines [ 10 ]. TLRs are important constituents of the innate immune system, which were applied to recognize and defend against foreign pathogens.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…PRRs comprise TLRs, RIG-I-like receptors (RLRs), and NOD-like receptors (NLRs). TLRs activate viral responses by recognizing pathogenic microorganisms such as viruses, bacteria, and mycoplasmas to release inflammatory cytokines [ 10 ]. TLRs are important constituents of the innate immune system, which were applied to recognize and defend against foreign pathogens.…”
Section: Introductionmentioning
confidence: 99%
“…TLRs are conserved and approximately comprised 10 functional TLRs (TLR1 to TLR10) in humans and 12 (TLR1 to TLR9, TLR11 to TLR13) in mice. TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10 are expressed on the human cell surface, while TLR3, TLR7, TLR8, and TLR9 are expressed on the membrane of intracellular vesicles [ 9 , 10 ]. TLR9 is a member of the TLR family whose function is triggered by the unmethylated CpG motif of microbial DNA, which initiates the immune response by inducing cytokines and many molecules [ 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…It has been reported that a variety of miRNAs contained in exosomes can regulate the expression of microglia Toll-like receptors (TLRs), thus acting on NF-κB to regulate microglia polarization ( Hajinejad and Sahab-Negah, 2021 ). miR-223, miR-101-3p, miR-26a -5p, miR-326, miR-182, miR-17-5p, miR-140-5p, miR-9, miR-let7, and miR-181c play a role in inhibiting M1 microglia polarization by downregulating TLR expression including TLR2 and TLR4 ( Kumar et al, 2015 ; Wang et al, 2015 ; Li et al, 2016 ; Li et al, 2017 ; Qian et al, 2017 ; Li et al, 2019 ; Li et al, 2020a ; Yang et al, 2020a ; Chaurasiya et al, 2020 ; Huang et al, 2020 ). In addition, miR-26b-5p inhibited the TLR signaling pathway by regulating the reduction of CH25H protein expression, which in turn inhibited microglia M1 polarization ( Li et al, 2020b ).…”
Section: Exosome and Microgliamentioning
confidence: 99%
“…In response to DNA damage, Chk1 and Chk2 are activated by PI3 kinase-related kinases ATM and ATR, respectively, aiming at many downstream substrates that coordinate cell cycle checkpoint activation, DNA restitution, and apoptosis [11]. Moreover, Chk1/2 has also been implicated in anaphase entry, chromosome condensation, and maintenance of genome integrity in somatic cells in the absence of DNA damage [12].…”
Section: Introductionmentioning
confidence: 99%