2022
DOI: 10.21203/rs.3.rs-1275321/v1
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Chk1/2 inhibitor AZD7762 blocks the growth of preantral follicles by inducing apoptosis, suppressing proliferation, and interfering with the cell cycle in granulosa cells

Abstract: Background Checkpoint kinases 1/2 (Chk1/2) has an important role in somatic cells development and oocyte meiotic maturation. However, the role of Chk1/2 in folliculogenesis has not been fully elucidated. The aim of this study was to assess the effects of Chk1/2 inhibition on ovarian folliculogenesis and granulosa cells development in mice. Methods Preantral follicles (100 µm- 120 µm) and granulosa cells from pre-ovulatory follicles (pre-GCs) of mice were isolated and cultured with or without Chk1/2 inhibitor… Show more

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